Generic Immunization Permission: Fill & Download for Free

There are attempts to use viruses against cancerOncolytic virusCancer-fighting viruses win approvalIs ebola a potential candidate? I doubt it <Caveat, I'm not an expert>.First of all, you would not want to use as a starting point a very lethal virus because you might kill the patient. Maybe it is permissible in some cases to use a few genes from a very lethal virus but only if it is studied well. Ebola virus has many targets including the immune cells, liver, spleen, kidneys, etc not just cause hemorrhage.Speaking of hemorrhage, afaik the ebola virus causes hemorrhage by deranging the coagulation cascade.Subsequent extensive viral replication leads to increased levels of additional pro-inflammatory cytokines, which then triggers the coagulation cascade....This would leave an activated, leukocyte-enriched, procoagulant endothelium, causing deregulated hemostasis, which could manifest clinically as hemorrhagehttp://www.nature.com/cdd/journal/v22/n8/full/cdd201567a.htmlThere is nothing I can see in the above mechanism of action that would make it attack only the vasculature of a tumor. It is generic, applicable to all blood vessels. This is the primary flaw in your plan IMHOImmune system evasion is not a big deal because you can just increase the dosage to temporarily overwhelm the immune system for a short time, enough to achieve your objective. Also the immune system is a last ditch safety measure to make sure that the virus doesnt kill or harm the patient. So we don't want a treatment that is good at immune evasion.

Quite likely, the Zircon missile does exist. And quite likely, it is an anti-ship missile, as stated.And, quite likely, many of the performance claims and capabilities are highly inflated Vaporware propoganda.The sponsored individuals and trolls invariably co-opt a picture of Boeing's X -51 Waverider, and claim it's the mythical ' Zircon '. Like so :Here's Boeing's X-51 wearing Lockheed Martin's livery ( with permission )Some Zircon Fanbois get ambitious, and combine the fake Zircon with another missile which isn't remotely similar, expecting you to believe they are the same. Mr.Jeff Jaworski here on Quora apparently missed the match when he inadvertantly posted this picture ?Which “ Zircon “ is the ( * cough * ) ' real ' Zircon ? This rip- off of the Boeing Waverider is dismissed by the propogandists as a representation only ( hah…), and the real, ' real ' Zircon form factor is, you know, ' top- secret '. Of course it is, which is why Putin squawks about it, and the sponsored shills drop mis and disinformation nuggets about it on social media. And self-proclaimed “ Russian military experts “ like Quora's own Pavel Fekula account make Kremlin approved ( always uncited ) claims regarding the Zircon.How does a missile fly at Mach 6+ 5–15 meters above the ocean, and retain targeting and evasive maneuvering capabilities while encased in a plasma cloud? Those are some of the Vaporware claims. And none of the shills and propogandists can back them up. I've read a bunch of “ defense “ attempts here, and alot of pointed questions to the sponsored individuals and strident Fanbois are ignored, or avoided. Or answered with misdirection attempts, and anecdotal claims of alleged ( yawn ) Russian advances in missiles and physics. Sure thing, comrades… Similar bloated claims were made about the last Big Deal anti-ship missile, the P-700 Granit.The defense against high speed, or Hypersonic anti-ship missiles is, as George Craig here on Quora has noted, is extending the picket line to extend the engagement window for these missiles. The AEGIS system can handle incoming missiles far faster than the various Zircon claims of Mach 6 - 9. Upgraded GaN based AESA radars equip flight 3 Arleigh Burke's, and will be retro-fitted on previous Burke's, along with upgraded computers and software. These upgrades will provide 30X the range and sensitivity over previous, very capable systems, allowing the tracking and targeting of thousands of potential targets. And despite nonsense claims of targeting immunity due to “ plasma stealth “, the ionized trail of a hypersonic missile is easily tracked by radar, and it's glowing heat signature easily tracked via IR.So the endlessly repeated, threat-inflated scary story attempts centered on the Zircon appear more like generic Russian weapon propoganda. Lots of empty claims, lots of shills parroting the Kremlin agenda. The same marketing department who brought you the claimed “ 5th Gen stealth plane !” in the Su-57 ; a 4th+ Gen plane victimized by its own propoganda department.So sure, there is a Zircon missile. It will eventually be found on some ships and subs. And I'd be far more inclined to swap a 5 series BMW even up for a used Lada than believe a fraction of the specious claims and hyper- inflated nonsense about the propoganda darling Zircon.Edit: 2.22.20 : Russia's much hyped propoganda pet Zircon missile seems to be far behind the bombast, and the timelines claimed. Read more here: Russian Navy's Top Officer Says Shadowy Zircon Hypersonic Missile Has "Childhood Diseases"

TL; DR: for the hoi polloi, don’t hold your breath, because it’s three to five years. And that’s if they do it fast, without any of the usual safeguards. Rich people and politicians, sometime sooner. Old people: not in this lifetime.Note: this is a very expanded version of a long-enough answer that I wrote the other day. For those following along, the top is lightly edited, with a short new paragraph under “Building”. The “Great Expansion” starts at “Vaccine delivery” All of it is specifically directed to this question.Assuming we ever get an effective vaccine, you mean? Let’s assume we do:Safety. I’m just going to note here: a phase 1 trial rarely results in evidence that the candidate vaccine is effective. That’s not the point of phase 1. The point of phase one is to make sure the candidate vaccine does not kill any one, doesn’t cause serious side effects, and hopefully doesn’t cause many moderate side effects, in a very small, very healthy, very young group of mostly white men (because there is a bias in medicine—many, many commonly prescribed medicines out there were never tested for efficacy or safety in women, minorities, or the elderly).Scientists don’t generally know if a vaccine candidate is really “safe” until larger trials, they just know it’s not super deadly. Larger, later studies are frequently done in India or sometimes in Africa, which introduces different biases, but my understanding is that, again, the young male bias remains.In any event, we’re nowhere near an effective, safe vaccine. What we have is one vaccine candidate that one company has demonstrated to be “safe enough” to proceed to a bigger effectiveness test, where they hope serious safety issues won’t appear. Even on the fastest track, waiving a ton of testing in favor of speed, a vaccine is minimum eighteen months away, and then you have to:Make enough for everyone. Nine Billion people. A million seconds is about 11 days. A billion seconds is about 31.5 years. 9 billion seconds is about 337.5 years. Think about what that means: if we manufacture one entire vaccine every second of every day of every year, it will take 337.5 years to get to 9 billion doses. 80%, for theoretical herd immunity, will take 270 years. If my math is good (it’s an estimate at best), 288 million doses (80% of the population) for the US will take roughly 95 years, assuming the US actually finds a vaccine and has the right to make it. To get it done, that’s a lot of factories. All of which must be built from scratch (see below).Now, these numbers assume no stopping for maintenance, no machine breakdowns, no errors in the vaccine batches, no work stoppages, no hurricane/tornado/flood/earthquake/whatever at the factory(ies). And if it takes more than one vaccine (say three, spaced three weeks apart), we’re never getting there.Building, equipping, and staffing factories. We don’t even have a factory built to manufacture the presumptive vaccine yet, because different vaccines take different kinds of factories. What will the vaccine be? an injection? a tablet? an oral gel? a liquid? Vaccine factories are specialized, and they produce specific vaccines. You can’t just ramp up an existing factory, unless we are unbelievably lucky. No, really, it’s unbelievable.The factories that already exist are already busy with vaccines for other deadly illnesses. And we’ve had zero luck with this disease. None at all. So. They can’t even start building the factory(ies) which will manufacture the vaccine until we know what the vaccine(s) will look like, and that’s very dependent on the structure of the molecule(s) which turns out to be effective.Also, here’s something I forgot about: Usually, maybe always, the molecule which is the active ingredient, is NOT manufactured in the same place as the final product. So there can be a shortage for the active ingredient. Or an inert ingredient. OR, either one of the factories can burn down, break down, suffer a work stoppage, any number of things.And don’t even get me started on packaging. Each one of those different types of vaccine takes a different kind of packaging, may or may not need temperature control, etc. That packaging also needs to be designed and manufactured (and, in the US, approved by the FDA). 9 billion packages, which is going to take a factory—several—of its own. And again, we can’t even build (or possibly find and retool) a factory/multiple factories until we already know what the delivery system is going to look like, which means we already know which vaccine is going to succeed.Vaccine Delivery. There’s a couple of ways to deliver vaccines, and in many countries, especially well-developed countries, delivery is very well set up. Pediatricians and health departments deliver to babies and children, and keep the vaccines on schedule, which is surprisingly important. In the US, pharmacies deliver flu shots to older adults. But if you are a middle-aged person and you don’t get the flu shot (bad, bad, bad you), what’s your vaccine delivery method? How will they follow up and make sure you get the second dose at the correct time? Suppose you’re a kid past the age of vaccination? A lot of parents don’t have doctors for their tweeners and teens.When I was a kid, I got a measles vaccination while I was in fourth grade. Without a permission slip. I had already had the actual measles. They were doing mass vaccination in the schools, which is how they got to herd immunity for so many different deadly diseases in the late sixties and early seventies. In any event, they don’t do that anymore. The idea that a child in the United States would get tested for tuberculosis in the eighth grade without a permission slip (yes I did) is laughable today.Refusal. What does the United States do about anti-vaxxers? Because not vaccinating thousands of deniers when we don’t already have herd immunity is a REAL problem. The only reason we can tolerate anti-vaxxers now in the USA is because the population is already at herd immunity. When a group of college students at a “christian” college get measles, they don’t give it to the surrounding population, because sensible people vaccinate. The college students usually catch it because one of their unvaccinated members wanders off to a third-world country without adequate vaccination, and brings it back on a plane. No one gets sick on the plane, because they’re vaccinated, but “christian” schools are full of the unvaccinated.Are we really prepared to have thousands of teens and young adults in hospital and dying because their parents are ignoramuses? Are we prepared to let the ignoramuses themselves die? (Please note: I am not talking about legitimate religious beliefs. But to my knowledge, there’s only one religion that has a legitimate religious objection that didn’t just “appear” in the last fifty-sixty years, and that single religion’s objection is rooted in a religious belief that existed for centuries before modern vaccination).Here’s another question: are we prepared, as taxpayers, to bear the expense of anti-vaxxers? Because this disease apparently causes long-term, permanent organ damage to a large percentage of the hospitalized who don’t actually die. Do we, as taxpayers, want to shoulder the burden of the permanently disabled who refused (or their parents refused) vaccination? Because right now, we do, for (say) measles.Time. The point is, to get to herd immunity, you have to vaccinate approximately 80% of NINE BILLION PEOPLE. Not 70%. And probably it’s 90%. We already discussed the factory issue. Now think about inoculating all those people. There’s no guarantee that needles won’t be involved-most vaccines are inoculations. You need trained people to inoculate. Plus gloves, and trash cans, and antiseptic wipes, and bandaids. And tables. And, theoretically of course—because “new normal”—offices and water coolers. All of this takes time. And money. Those trained people have homes and families, and weekends. And vacations. I’m just saying, there’s gonna be lines.Which brings up an interesting question: Who gets vaccinated first? Kids? Older adults “most at risk”? AHAHAHAHAHahahahahaha. Oh. Did I do that out loud? Pardon me.It’s going to be the factory workers and administration at the factory(ies), which is obviously absolutely necessary. Then, the first wave of vaccinators. The CEO/families at the companies that own the factory, then the C-suite/families at the company that owns the vaccine. Maybe the entire company, plus families. Which, okay, just rewards.But then, I’m telling you right now, rich people and politicians. C-suite employees at large “essential” companies. And those peoples’ families. Not just in the US. Around the world, politicians, the very wealthiest of the wealthy, billionaires, the connected, the corrupt, and their immediate families will absorb the first 50 million or more doses. Get in line, peasant.THEN we’ll get around to medical staff. Probably, it takes 50 million or more doses to get all the nurses, doctors, and first responders and possibly their families. Then and only then (despite the fact that this is absolute BS) “non-essential” health workers, like kitchen staff, custodians, and lower level administration will get vaccinated (not family). Bus drivers, train conductors, stews and pilots (not family). Delivery workers and post office workers. Again, not family. Workers in meat plants. The military. Then, probably the truly essential workers, like electricians who deal with power outages, and sewage and garbage professionals. But none of those people’s families. If I had to guess, teachers and school administration next. School staff. Then, finally, school age kids. Please note, we haven’t hit nearly any office worker yet.This, of course, all assumes that you’re not in a corrupt country where money can buy anything, in which case, the top one percent in most of the world comes to that country—not just the billionaires—and all get vaccinated before this group in that corrupt country. So, Saudi Arabia. Among others.People already over eighty are never going to see a vaccination. Probably over 65 or so. The powers that be will do the math (or already have) and recognize that the cost/benefit just isn’t there, given the limited availability for the foreseeable future and the probable higher danger of early vaccines. At the very best, older citizens will be offered a very limited lottery. I’m sixty. I’m not happy about this. But this is reality.Also, remember the coronavirus is novel. What you need to understand is that when we started mass vaccinations for measles and polio and small pox and diptheria and mumps, the majority of the living adult population and lots of children all over the world were already immune. Wiping out or controlling these deadly diseases “just” required vaccinating about 90% of the non-immune of a generation of children, not nine billion people.Starting from a large existing base of immunity, it took fifty years to wipe out smallpox. We’re 20 cases a year away from polio eradication after more than sixty-five years, and measles still regularly breaks out on US “christian” college campuses. Governments didn’t really need to make these choices, because by the time you were eighty, you had had whatever the deadly disease was, you survived, and you were immune. Also, very few people made it to eighty, but that’s another post.With this novel coronavirus, we aren’t starting with a large existing base of immune. We’re starting from a standing stop.Governments are going to invest the vaccinations on the people who will provide the most economic value per vaccination spent: essential workers, young adults, adults with at least a few good economic years left in them, the more, the better. Richer countries WILL get vaccinated before poorer ones. I’m not arguing morality here. This is just the facts. Don’t shoot the messenger.My point, and I do have one: If you are a run of the mill knowledge worker working from home in Poughkeepsie, don’t hold your breath waiting for a vaccination anytime in the next three to five years. There’s a list, and you are not on it.Administration. At least we have computers. But we’re gonna need a database to followup, especially with the early vaccinated, because they are going to be at higher risk of the vaccination failing (because we’re pushing forward too fast).There’s probably, but not necessarily, a database that can handle this, in which case, it just needs to be pushed out to hundreds of government entities, some of which (including the US) still have computers from the 80s. If they have computers. And regularly available electricity.And if there isn’t a database already built to handle this, I can promise you, no one is thinking far enough ahead to start building one now. It took someone effectively banging on the door of the White House to get the FDA to give a permission that had to be given now to solve a problem with this vaccine that won’t happen for several years. You would think the FDA would have thought of it itself. We don’t tend to be a country of forward thinkers. Even when it’s only 2 years.After the corrupt and the rich get vaccinated, who decides which countries get how much vaccine? One of the reasons so many different vaccine candidates exist, is because governments all understand that if only one vaccine is developed, everyone will be beholden to one particular country for the vaccine.It’s not like the US, frequently the innovator on vaccines and vaccine delivery, has been a bastion of helpfulness and trust lately. Particularly if those other countries aren’t white.And furthermore, we’ve acted selfishly before. I’m not saying we hoarded polio vaccination in the early stages. Why would I ever suggest that? I’m not suggesting that insulin is unreasonably expensive in this country because the holders of the US patents are profit hungry gorgons who patented “better” insulin (okay, it is) and then refused to manufacture the unpatented generic and prevented importation from other countries which continue to manufacture it. Why, why would you even think such a thing?There’s are reasons there are 92 candidates for a vaccine, and only one of those reasons is the high failure rate to get to effective and safe. Countries are thinking, maybe correctly, that other countries will withhold the vaccine to gain a political advantage. Or maybe just to vaccinate all of their own citizens first. Reverse engineering a medicine isn’t nearly as easy as they make look in the movies. And it’s not unreasonable to think that such a country might be the target of an invasive force: Russia, China, or the US. It’s no longer unthinkable. This is what three years has done to the world.Who the hell is going to pay for all this? How? New factories don’t build themselves. People don’t train themselves to deliver vaccines. All of this has to be done before these companies see one thin dime in payment. Not profit. Payment. There’s no way to tell if they’ll be first to market. Or if their vaccine will turn out to be safe enough. Or if one of the other 92 candidates will prove to be safer and more effective, rendering theirs less desirable. And who covers the lawsuits when it turns out to be unsafe ten million injections in?It used to be that a) we weren’t as litigious; and b) the government paid for development grants, etc, because governments realized that wiping out fatal disease was a good thing for everyone, not just the recipients. But the governments are now all effectively bankrupt, it’s going to get worse. And, in the US at least, there’s a strong stupid movement against paying for public health, because, you know, we should all just volunteer to die.Any vaccine reporting to the contrary, by anyone, is just a placebo. Sorry about your balloon.