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No F-35 has crashed or been shot down as of today (2nd of January 2018), although one USAF F-35A has been written off (and turned into a practice jet for training maintainers in repairing battle damage) after it had an engine failure in 2014 (a big investigation was launched, the cause was identified and a fix was applied to all F-35s before the end of 2015).(The dark spot in the middle of that bottom image is a hole where a rotor broke apart at about max throttle and tore through the aircraft, including through a fuel tank).There are more photos and more information in the USAF’s investigation report here.Other F-35s have been damaged in various ways (bird strikes, deer strikes, electrical fires, a tail-wind engine hot start, etc), but all of those F-35s were able to be repaired and put back into service.Something that this question might be referring to is claims that came about in late 2017 that a Syrian S-200 had shot at an Israeli F-35 and damaged it. This is all speculation based around a coincidence where Israel reported that an F-35 had been recently damaged in a bird strike (hitting 2 storks) on the same day that they reported that Israeli aircraft on a reconnaissance mission were engaged by a Syrian S-200 and Israel returned fire with a second flight of jets.Common sense prevails here however:The F-35 was put back into service days later (reportedly).No one has reported seeing an F-35 in the air when the SAM fired.No one has reported finding aircraft wreckage despite Syria’s war being heavily documented and watched.Israel was rushing to put their F-35s into service in 2017, but this shoot down claim came nearly a month before they declared IOC (combat readiness) with their F-35s; flying combat missions even earlier than this milestone would be possible but insane.There are people and photographers that keep track of aircraft serial numbers around the world; no one has reported any of Israel’s 7x F-35s disappearing (and repainting new serial numbers can take a couple of days, making it impractical to hide a jet's loss).As mentioned above; F-35s have been hit by birds and even deer (while on the runway / taxiway) before, so an Israeli F-35 having a birdstrike has precedent and is to be expected for a coastal nation.The S-200 SAM fires a massive missile with a giant 500lb warhead that releases tens of thousands of thick metal fragments (an air-to-air missile has a ~50lb warhead) during the Cold War, these warheads could be swapped for a nuclear warhead to take out bomber formations). The chances of any aircraft getting hit by this warhead and surviving long enough to make a landing are super slim.To put it simply; there’s no evidence that an F-35 was flying over Syria, no evidence that any Israeli plane was actually hit and no evidence that an F-35 was hit by anything other than some birds.

In the US in the 20th century there have been two occasions when US troops attacked US civilians. There are many other cases when US troops have faced US civilians but did not attack them.On 28 July 1932 at 4:45 p.m., commanded by General Douglas MacArthur, the 12th Infantry Regiment, Fort Howard, Maryland, and the 3rd Cavalry Regiment, supported by six M1917 light tanks commanded by Maj. George S. Patton, formed in Pennsylvania Avenue while thousands of civil service employees left work to line the street and watch. The Bonus Marchers, believing the troops were marching in their honor, cheered the troops until Patton ordered the cavalry to charge them, which prompted the spectators to yell, "Shame! Shame!"Shacks that members of the Bonus Army erected on the Anacostia Flats burning after its confrontation with the army.After the cavalry charged, the infantry, with fixed bayonets and tear gas (adamsite, an arsenical vomiting agent) entered the camps, evicting veterans, families, and camp followers. The veterans fled across the Anacostia River to their largest camp, and Hoover ordered the assault stopped. MacArthur chose to ignore the president and ordered a new attack, claiming that the Bonus March was an attempt to overthrow the US government; 55 veterans were injured and 135 arrested.A veteran's wife miscarried. When 12-week-old Bernard Myers died in the hospital after being caught in the tear gas attack, a government investigation reported he died of enteritis, and a hospital spokesman said the tear gas "didn't do it any good."During the military operation, Major Dwight D. Eisenhower, later the 34th president of the United States, served as one of MacArthur's junior aides. Believing it wrong for the Army's highest-ranking officer to lead an action against fellow American war veterans, he strongly advised MacArthur against taking any public role: "I told that dumb son-of-a-bitch not to go down there," he said later. "I told him it was no place for the Chief of Staff."Despite his misgivings, Eisenhower later wrote the Army's official incident report that endorsed MacArthur's conduct.However, the defeat of the "Bonus Army" while unpopular with the American people at large, did make MacArthur into the hero of the more right-wing elements in the Republican Party who believed that the general had saved America from a communist revolution in 1932.The Kent State shootings were the shootings on May 4, 1970, of unarmed college students by members of the Ohio National Guard at Kent State University in Kent, Ohio, during a mass protest against the bombing of Cambodia by United States military forces. Twenty-eight guardsmen fired approximately 67 rounds over a period of 13 seconds, killing four students and wounding nine others, one of whom suffered permanent paralysis.US military aircraft were used as spotters in the “Battle of Blair Mountain” in 1921.I am not aware of any incident were US soldiers were ordered to attack US civilians and refused.

A lot of the answers I am reading here about the Columbia crew are incorrect. Some mix up Challenger and Columbia, and others simply don't have all the facts straight. As the shuttle passed over the coast of California early on a Saturday AM, things to the astronauts were looking fine. The shuttle was performing a maneuver called "S-turns", which are designed to burn off energy (and slow the shuttle down) during re-entry. It was about this time when the shuttle first started losing tiles and other debris. Because of a large hole in the wing that occurred during launch, temperatures in excess of 4000 degrees entered the interior of the wing. Initially, the high temperature caused a number of temperature sensors to fail. That information was not reported to the crew, either from Mission Control, or automatically. As the damage continued, the wing's aerodynamic shape started to change, causing increased drag. The control surfaces moved automatically to compensate for this (driven by hydraulics), and everything seemed normal to the crew. Meanwhile, Mission Control was starting to see more cascading sensor failures, but again that information was not reported to the crew (not that it would have mattered). Mission Control started looking more closely at the sensor failures.The high temperatures eventually reached the wheel well, and the astronauts got their first indication that something might be wrong. The left wheel indicator was showing gear down and locked, but the wheel door was still closed. (For those interested, the landing gear indicator in the shuttle showed a “barber pole” (or indeterminate indication.) At the same time, the control surfaces reached their limit, and could no longer counter the damage to the wing, which at this point was literally falling apart. The nose thruster started to fire to counteract the increasing drag, and continued to do so until the vehicle ran out of fuel, prior to breakup. At this point, the astronaut's received another warning. A yellow light on the lower part of the console lit up, showing that less than 20% RCS fuel remained. Despite the growing problems, the shuttle was still (more-or-less) under “control”.At the end, things happened quickly. The high temperatures reached the hydraulics system, which resulted in loss of pressure, and immediate loss-of-control (known as a ballistic trajectory). The vehicle pitched up into the direction of flight, causing communications with the ground to cease. For the next ~30 seconds, the astronaut’s tried in vain to reestablish hydraulic pressure, and amazing were partially able to do (a fascinating story). Unfortunately, it was way too little/too late, and shortly thereafter aerodynamic stress caused the vehicle to break up.So what happened to the astronauts? Just prior to the vehicle breaking up, temperature and pressure inside the crew cabin was normal. So they were all alive and well until breakup. Some of them were not fully locked into their seats, and some had not yet finished putting on their pressure suit. When breakup occurred, the power went off in the cabin. Each astronaut had chemical light sticks in their side pocket, so the interior of the cabin had light. Shortly thereafter, the cabin depressurized. For whatever reason, the 2 (?) astronauts who had on their full pressure suit, and helmet failed to close the visor and activate their emergency O2 supply. Even if they had, temperature and aerodynamic forces would probably have made this a non-recoverable situation.The Columbia Crew Survival Report is an excellent source as is the original accident investigation report.