Metabolic Detoxication Questionnaire: Fill & Download for Free

I'm a psychotherapist, but I think differently about this issue than many. This is an honest answer, but one I don't relay to clients because the advice would not be popular.First measure. Give up sugar.No desserts, ice cream, sodas and fruit juices. Most of the population is pre-diabetic because of excessive sugar use. It's not just the cavities (which you stop getting when you abandon the sugar). It's not just the empty calories which fill you so you don't reach for what you actually need to power a healthy body. It's that the sugar prompts your body to improperly metabolize minerals which become less accessible AND that diabetes awaits you, the result of cumulative damage. You may feel virtuous because you don't smoke or don't do drugs, but the sugar is a big problem.Many times, anxiety symptoms or panic attacks relate to hypoglycemia. Or people get 'hangry'. Or they medicate negative emotions like sadness with sugar and it spurns a vicious cycle of fatigue, rebound depression, weight gain, low self-esteem. Anyone who is really serious about making improvements should consider quitting sugar for good. (I did, by the way. In 25 years of practice, I only had one client who reported he had done the same. A very competent young man, with good will power - obviously!)Secondly. Find your local Chinese medical school and go to see an intern at the clinic. Let's look under the hood and see exactly where you're at. What are your imbalances? Each person has some. Treatments are dirt cheap. They spend a lot of time with you and can talk about your constitutional type. Good to know who you are and what you need to watch for. You should not be eating any flavour in excess. Too much spice creates heat which disturbs sleep and promotes worry and anxiety. Too much sweetness promotes dampness, apathy, depression, laziness. And so on. Have your intern explain your constitution and the sorts of foods that will help you feel well and age well.Ask the student whether Ginger is good for your constitution. For some, it creates heat but for 90% of people, boiling fresh ginger and having a little cup of tea after meals aids digestion and tonifies the body with iron and many nutrients. Notice how young Chinese people always look? Get on the bandwagon! How about reading about it? Between Heaven and Earth by Beinfield and Korngold is fabulous. You only have to read the first and second sections to get a wonderful philosophy to guide you in life and a way of understanding the people around you. It's a very rich psychology that helps you understand the five essential personality types. Find yourself, your friends and your family, and the world will make sense!Thirdly. How about some Jordan Peterson? Care to listen to lectures, even small bits of lectures, on a daily basis? You will get inspired. You could read his books but you have to plow through them. For starters, listening is better. It will start to shape the way you think and the way you think needs shaping. Why? Because you grew up on TV and movies. If you watch a documentary called “Hollywoodism” you will gain some understanding how the perfection that you have seen depicted in TV shows and movies has absolutely contorted your understanding of life and other values. Which takes us to the next bit of advice which you are not going to like.Four. Now is the test. If I haven't lost you already: Give up TV shows and movies. I dare you! Again, I did it myself, detoxing from a childhood steeped in visions of perfect people getting perfect outcomes. The entitlement that characterizes normal people derives from watching idealized situations, where everything wraps up by the time the credits roll. In contemporary times, we see a lack of gratitude because every life is compared to the perfect ideal depicted on the silver screen. If you stop watching, over time, you will lose patience to watch it. You will also notice that when you are not inundated with crude language that barrages us from movies, you may stop using that language yourself. I did. No more.You can see that we are on a purification program here and when you purify your speech suddenly, when people use those four letter words, the meaning of those words are no longer invisible. You see – in front of your very eyes – the meaning of the word that is being said! It's shocking! You lose the thick skin. You are now permeable to words. You will be in better shape to use words when you can really hear them. Cleaning speech, in my opinion, is part of the "clean your room" task that Jordan Peterson invites us to do.One more point about the TV. When you sit in front of the TV to relax what you may not realize is that if you were getting a brain scan you would be showing the brain patterns of a newborn baby. Complete inactivity in the left brain.So what you do with your time if you are not watching TV shows? Sudoku. You will notice your brain start to think differently. How about online, BrainHQ? Tweak your intelligence. You will process better and faster. You will see your progress even in one sitting. Sharpen up. How about taking up creative activities. Don't let some TV writer entertain you. Maybe you can mine the contents of your own imagination. Write a book about something and put it up on amazon. Take up a musical instrument. Start playing with animation software on the web. You will be amazed at the neat things you come up with.How about some important reading? I'm recommending books that let you look at life and yourself very differently.Second Wind: navigating the passage to a slower, deeper, and more connected life by Dr. Bill Thomas. Brilliant. You will read it over and over to truly marinate in these ideas. He will give you a look at our times and help you locate yourself. Beautifully written.The Path: what Chinese philosophers can teach us about the good life by Michael Puett and Christine Gross-Loh. We need to get out of the westernized worldview and I think there are rich pearls in the eastern perspective that can make for a better life.How the World Sees You: Discover your highest value through the science of fascination by Sally Hogshead. Brilliant. A map of personality types and helping you understand who you are, your uniqueness, so you can continue to tweak and best express THAT. You don't have to be the master of all things. You have to have the insight to understand what your gift is and to take that to its most magnificent expression.What Your Body Is Telling You by David Rowlands. This is a very interesting questionnaire that people can take which might help identify nutritional weaknesses and point out those foods that are not adequately represented in your diet. This questionnaire may show you what, down the road, would be first a subclinical nutritional deficiency you would experience and then a real nutritional deficiency, if you keep up certain dietary patterns that do not adequately meet the needs of the body. The idea is not to pop supplements. The idea is to bring foods into your diet that need to be part of your life.I believe that contemporary people with normal lives are all messed up because their intake has been off. A typical diet will not necessarily provide all the necessary vitamins and minerals. Too much TV, movies, fantasy. Not enough excitement about learning about the contours of reality, which is magical and fascinating, if you will only inform your view of it.So here are my ideas for a mental health makeover. I may not get any takers, but if there were, the results would be dramatic! Seriously...

I don’t know of any research, at least any research that get’s it right, that ties the whole thing together. I’m not a doctor. Electronic medical records is something I have worked with since 1979 and given it substantial thought. However, I devoted more than 30,000 hours since 1979 to solve this problem. I cured myself from FMS, CFS, congestive heart failure, IBS, MCS, etc. So here we have FMS-CFS that have been attributed to multiple causes through the years from physical trauma to viruses or bacteria. In high resolution symptoms so instead of diagnosis level “peripheral neuropathy” one might instead describe all the different symptoms. Something amazing happens. The causes become visible. FMS/CFS are something that develops as opposed to “catching”, like the flu.Basically FMS/CFS are variations on “failure to heal”. As the body keeps trying to heal, from anything, often around 3 to 6 months the symptoms start changing. After a certain point some resources get too low for “X” to heal and “Y” and “Z” symptoms appear and are both deficiency symptoms. Basically a person gets slow motion refeeding syndrome. This gets a person stuck in a multi way deadlock. The basic deadlock is a partial methylation block teamed up with ATP block. The most basic level of the block is MeCbl with L-methylfolate on one end and AdoCbl with L-carnitine fumarate (90% of people, ALCAR 10%) at the other. Vit D, magnesium, zinc and some other items can deadlock these items as well. Each branch, methylation and ATP, has another half dozen or more items that affect various portions of these functions. Typically on the third day after methylation starts a person can feel very sick as they go into potassium deficiency and l-methylfolate deficiency (which happens by compartment).Then each time there is more cell formation. Then the response is limited by ATP production, AdoCbl and l-carnitine fumarate which as soon as it is started increases the need for potassium and methylfolate again in a few days. And to avoid adding 20 or 30 more items into things that stop healing one is taking all the basics before starting and also needs to avoid some things. Once one gets the basic cycle s going there are patterns of repeating symptoms as different things run out. It took me 6 years to run low enough on copper for symptoms to occur (low doses in basics) and 5 years to recognize the induced copper deficiency symptoms and a lot of damage happened. I have many of the symptoms patterns mapped. With FMS/CFS the first 150 symptoms are relatively quick and easy. The tough ones are latter appearing symptoms that look familiar but are in a different pattern. It is quite complicated.Added 10/21 - When one tries the nutrient that is the actual item deficiency preventing cell formation, the difference can be noticed quickly.MeCbl - sublingual or nasal spray, may be noticed in 5 minutes, 75% of those likely to respond by questionnaire respond noticeably within 1 hour, beneficial effects may disappear by day 3 when refeeding deficiency symptoms become prominent, especially methylfolate and potassium deficiencies.AdoCbl - sublingual, may be noticed in 5 minutes, 75% of those likely to respond by questionnaire respond noticeably within 1 hour, beneficial effects may disappear by day 3 when refeeding deficiency symptoms become prominent, especially methylfolate and potassium deficiencies.L-methylfolate - Deficiency symptoms start changing within several hours, reinvigorated folate deficiency symptoms (refeeding syndrome by compartment) appear along with potassium deficiency symptoms.L-carnitine fumarate - Oral capsule, may produce noticeable results in 30–60 minutes improving energy and affecting mood. Again, about day 3 symptoms change to increased refeeding syndrome symptoms of potassium and methylfolate deficiencies.Copper - Copper and other trace nutrients usually take longer to appear and affect fewer symptoms. When copper is deficient and taken, positive effects can be seen often in 2–4 hours and no doubt in 24 hours. In 3 days if a small dose of copper is taken, the positive effects start fading and the deficiency symptoms increase. Also serum copper decreases after small doses, possibly by compartment in way similar to increasing deficiency symptoms with small doses like l-methylfolate. I had to titrate to 25 mg daily to get steady improvement.Version 2.2 08/10/2016 A work in process, incomplete, limited testing, people come in many variations, use at your own risk.INDUCED DEFICIENCY SYMPTOMS FROM REFEEDING SYNDROME. This can follow 5 days of food deprivation, anorexia, or sort of a pinpoint starvation via vitamin or mineral or amino acid deficiencies. Whatever the “most needed” item is will often cause a strong response. The first usual notable symptoms occur on typically the third day of starting a previously insufficient nutrient. For instance it was noted in the 50s with injections of B12 with potassium deficiency (hypokalemia) as a side effect. It is dangerous and can be unpredictably fatal if not corrected and the cause is continued. When they say people are dying in Syria after they have been starved and given food, they are often sufferring REFEEDING SYNDROME. When previous symptoms returnGroup 1 – Hypokalemia onset. Often called “detox”. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (Cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.IBS – Steady constipation, Nausea, Vomiting, Paralyzed Ileum,Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weaknessAbnormal heart rhythms (dysrhythmias), increased pulse rate, increased blood pressureEmotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.Group 2a - Both hypokalemia and l-methylfolate deficiencyIBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipationGroup 2b – Either or both hypokalemia and l-methylfolate deficiencyHeadache, Increased malaise, FatigueGroup 3 - Induced and/or Paradoxical Folate deficiency or insufficiency, partial methylation block to methyltrap on 1 or more internal triage levels. Frequently called “NAC DETOX” or “GLUTATHIONE DETOX”. Can be caused by folic acid, folinic acid and for some people, like me and quite a few others, excess vegetable folates. Further excess B1, B2, B3 and/or inositol can increase methylfolate deficiency symptoms.These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.Old symptoms returning in a general sense, a person may have had onset of these hundreds of time if they are on the borderlineEdemaAngular Cheilitis, Canker sores,Skin rashes, increased acne, Increased itchy acne on scalp and face, Skin peeling around fingernails, Skin cracking and peeling at fingertips, painful cracks in the skin at the corner of fingernails at approximate right angles to nails, can take months to occur and it may be only non mood or neurological symptoms.IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipationHeadache, Increased malaise, FatigueIncreased hypersensitive responses, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptomsIBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract,Coated tongue, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Increase irritability, Heart palpitations,Longer term, very serious:Loss of reflexes, Fevers, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, bleeding easily.Group 4 - HyCbl onset, degraded MeCbl onset, MeCbl after photolytic breakdown onset.Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.Group 5 – Copper deficiency after methylation startup has been achieved which often starts refeeding syndrome. 50mg or more of zinc has been indicated as a possible cause. 200-400 mg of zinc has been linked to copper deficiency. Excess supplemental or environmental manganese is linked to copper deficiency. Any or all symptoms can occur at “low normal range” copper tests.Demyelination of nerves similar to Sub Acute Combined Degeneration except that methylation and ATP startup has occurred, and copper deficiency favors damage to the upper motor neurons with perceived muscle weakness. Brittle nails. Sleep disorders. Mood (especially depression perhaps) and personality changes. Connective tissue breakdown. Spider veins. Varicose veins. Shrinking gums. Gum disease not responsive to usual measures. Unstoppable tooth decay on exposed areas without enamel. Low testosteroneGroup 6 – Excess P-5-P, an active form of B6 that appears to drive hematocrit.High hematocrit. The blood thickens and doesn’t pump as easily. Deep vein thrombosis can result. Other suspected circulatory hazards. Sometimes linked to high testosterone when lowering P-5-P might reduce it.Group 7 – Excess B-vitamins affecting methylationWhen taking the active B12/folate deadlock quartet (AdoCbl, MeCbl, Metafolin, L-methylfolate) Excess B1 - Thiamin, Excess B2 – Riboflavin, Excess B3 – Niacin and/or Excess Inositol can all produce an excess need for potassium to deal with Groups 1, 2a and 2b symptoms and/or produce an excess need for l-methylfolate to reduce groups 2a, 2b and 3 symptoms. A person might not be able to correct by taking potassium or folate and may need to reduce B1 <= 15mg/day, B2<= 10.2mg/day, B3 <=50mg, and inositol below an unknown quantity.Group 8 – Boron insufficiency.Arthritis swelling and pain, can be reduced by BoronContribution to fatigue, neurological effectsHealth Benefits of Boron | Organic FactsAlthough all of the deficiency symptoms of boron are not fully understood, it is known that boron deficiency might result in the abnormal metabolism of calcium and magnesium. Some of the other symptoms include hyperthyroidism, sex hormone imbalance, osteoporosis, arthritis and neural malfunction.

REFEEDING SYNDROME - A PROTOTYPE pragmatically based guide to survival and effective healing. USE AT YOUR OWN RISK.Version 1.1, 11/05/2018I and some thousands of others have healed ourselves to various extents with this and perhaps other variations of B12/folate treatments. I can't speak for any doctors or their patientsLet's look at the nature of the problem. in 1948 Cyanocobalamin won the Nobel Prize as B12 In 1959 x-ray crystallography proved that the vast majority of cobalamins in beef liver extract (like the human body) was MeCbl and AdoCbl (Methylcobalamin and Adenosylcobalamin), the two immediately active forms of b12 in mammals and that the cyanocobalamin was generated by a lab mistake from those two active cobalamins. CyCbl is an inactive post waste production cleanup (Cyanide) form of cobalamin that is favored for excretion.However, a small percentage of people were able to convert enough CyCbl to MeCbl-AdoCbl fast enough to feel a surge of energy from the cobalamin. The AMA declared all effects felt quickly were clearly placebo, said they would take actions to prevent doctors from giving people B12 because they claimed effectiveness from it. Those people who felt effects also sometimes had low potassium (hypokalemia) symptoms because of red blood cell production increase. These are people who were actually having healing going on for the only recognized b12 deficiency symptom, large red blood cells, and they would be denied B12 because of dangerous side effects.By 1959 CyCbl was well established in research and the medical establishment. The tests that had to validate the genuine shortage of B12 (pernicious anemia basically) became the basis of giving B12, not effectiveness.During the last 15 years that MeCbl and AdoCbl have been available many doctors have been floundering around because the research hasn't been done and some of them with considerable effectiveness, and they get in trouble for instance ,in the UK, which uses HyCbl as it's official defined B12.All of the "standards of care" call for CyCbl and folic acid in the USA. So despite what my medical records say, that I have to have 3 x 10mg MeCbl injections daily and 24mg of Metafolin, the standards of care say nothing about that. So I could be given CyCbl and folic acid, putting me into severe deficiency starting in hours and possibly killing me with complete safety for the doctors becasue they are treating me according to the standards of care whereas they could get sued for giving me what I need in MeCbl, AdoCbl, Metafolin and L-carnitine fumarate. The "official" treatment for me is HyCbl (doesn't work for 1/3 of people like me as opposed to CyCbl with 0 to minus 100% effectiveness., folic acid (partially active for up to 50-70% or so of people but also having up minus 100% effectiveness and l-acetyl carnitine (ALCAR). This combo is the official treatment for my diagnosis and it works poorly to not at all for such people. This combination would put me into methyltrap and demyelination (like Sub Acute Combined Degeneration and MS for example) starting within 2 weeks.I have cured myself of most all the symptoms of FMS, CFS, ME, congestive heart failure and many neurological symptoms are in remission. I had a couple of dozen other diagnoses during the decades, 100% of them useless for treatment and in retrospect of knowing what healed me, 100% wrong. Of the 100+ physicians I sought answers and treatment from during the decades, 100% of them were wrong. 100% of the treatments didn't work or were worse than nothing.Severe b12 deficiencies, the first ones they are usually willing to diagnose, are the cause of excess homocysteine and excess Methyl Malonic Acid to be generated causing multi system/organ breakdowns of all kinds and death. By the time these are diagnosed the body is damaged and in failure mode.I only look at symptoms as most of these diagnoses around these answers revolve around CyCbl (HyCbl) and folic acid or lots of drugs and don't work. Folic acid, CyCbl and HyCbl are 1/100 to 1/10,000 of the effectiveness of MeCbl, AdoCbl and l=methylfolate.The following list is composed of my experiences, some symptoms I didn't have but were relieved for others and an initial international list of symptoms that responded to b12 treatment. I had over 200 symptoms myself.Avoid glutathione, NAC, whey, Folic acid, folinic acid, HyCbl, CyCbl. They all have the ability to produce paradoxical folate deficiency or partial methylation block or healing by internal triage level or methyltrap and some other variations on ATP and methylation deficiencies.This list has appeared in various forms on various threads Active B12 Protocol Basics at Phoenix Rising some years ago.SYMPTOMS LIST 01/03/2014 V 1.0Copyright 2014, Frederick D. Davis, aka Fred Davis, aka Freddd, aka Davis Software Development, copied from original manuscript.In this post this is a list of symptoms that are mine, and others experience of these nutritional items in relieving their symptoms, and in a very few instances reflect research and successful practice, such as p5p for Hcy and Liver extract studies of several disorders in old journals. In some instances the same symptoms might have different combinations of nutrients. However, I have used no quotes from any source. This list of symptoms is derived from the an N=1000 questionnaire development. These are the symptoms that responded to the nutrients as listed. I did the 1000 symptoms histories myself. These are the some of the results from my 30,000 + hours of work for myThese symptoms responded almost entirely or entirely with basics 5 star MeCbl – methylcobalamin – Methylb12 - Mb12 - Mecobl . Many started improving in hours. Others took 9 months to correct.morning joint stiffness and painpalenessacid refluxnauseadaily vomitingstanding with eyes closed, lose balancehands feel gloved with loss of sensitivity - glove anesthesiafeet feel socked by loss of sensitivity - stocking anesthesiaglove and stocking anesthesianeuropathic bladderunable to release bladder, mild to severeunable to fully empty the bladderfecal incontinence - occasionally to frequentlydiminished hearing - gradual onset or present for life, sudden return possibletinnitus - ringing in earsalways feeling coldintolerance to loud soundsintolerance to multiple soundssleep disordersnon restorative sleepNight terrorsProlonged hypnagogic or hypnopompic states transitioning to/from sleepSleep paralysisalteration of touch all over body, normal touch can be unpleasant and painfulalterations and loss of tastetaste hallucinationssmell hallucinationssound hallucinationsvisual hallucinationsalterations and loss of smellloss of smell and taste of strawberries specificallyloss or alteration of smell and taste of potato chips specificallyroughening and increased raspiness of voice, mb12 can smooth it in mid wordblurring of vision - can be sudden onset and sudden returnVisual impairment can be seen; ophthalmological exam may show bilateral visual lossoptic atrophycentrocecal scotomatahypersensitivity/intolerance to bright lightintolerance to loud soundsintolerance to multiple soundsburning muscle paindiminished hearing - gradual onset or present for life, sudden return possibletinnitus - ringing in earssore burning tongueThis is a list of symptoms that are mine, and others experience of these nutritional items in relieving their symptoms, and in a very few instances reflect research and successful practice, such as p5p for Hcy and Liver extract studies of several disorders in old journals. In some instances the same symptoms might have different combinations of nutrients.These symptoms responded strongly first to 5 star MeCbl and then Metafolin with basics. Many started improving in hours. Some took 7 years to correct.Bursitisstomach not emptyingfrequent vomitingacid regurgitationdyspepsiaflatulencealtered bowel habitsabdominal painloss of appetite for meat, fish, eggs, dairy, the only b12 containing foodsnutrient specific anorexiaintermittent constipationintermittent diarrheairritable bowel syndromesores, ulcers and lesions along entire GI tract or any partanorexiaBulimiaHypersensitivity to touchHypersensitivity to odorsHypersensitivity to tastesHypersensitivity to clothing textureHypersensitivity to body malfunctions, symptomsHypersensitivity to sounds and noisesHypersensitivity to light and visual stimuliHypersensitivity to blood sugar changesHypersensitivity to internal metabolic changesHypersensitivity to temperature changesburning bladder (no UTI)painful urgency (no UTI)burning urethra (no UTI)Low blood serum level - below 550pg/ml, Japanese Standardelevated MCH (Mean Corpuscular Hemoglobin)elevated LDHbig fat red cells (when said this way usually with happy or healthy modifying it completely misinterpreting results of MCVplatelet dysfunction, low countwhite cell changes, low counthyper segmented neutrophilsheadachesinflamed epithelial tissues - mucous membranes, skin, GI, vaginal, lungsinflamed endothelial tissues - lining of veins and arteriesmucous becomes thick, jellied and stickyasthmachronic cough that mimics asthma but isn'tchronic sinus congestiondermatitis herpetiformis, chronic intensely burning itching rashfrequent infected follicles or acne type lesions all over bodychronic infections, many varieties possibleSeborrhic dermatitisdandruffeczemadermatitisskin on face, hands, feet, turns brown or yellow if anemia occurspoor hair conditionthin nailstransverse ridges on nails, can happen as healing startsmouth sensitive to hot and coldsore burning tonguebeef-red tongue, possibly smoother than normalsore mouth, no infection or apparant reasonteeth sensitive to hot and coldcanker soreswith p5p addedElevated blood serum Hcy, borderline or higherThese symptoms responded relatively partially first to 5 star MeCbl and then very strongly to Metafolin with basics. Many started improving in hours. Some took 7 years to correct.splits/sores at corners of mouth -angular cheilitisimpaired white blood cell responsepoor resistance to infectionseasy bruisingpronounced anemiamacrocytic anemiamegablastic anemiapernicious anemiadecreased blood clottingMCV > 93 first warning,MCV > 97 alertMCV > 100 outright macrocytosisMCV > 105 urgently needs treatment, severe problemPlus Vitamin EChild with neural tube defectsmother of child with neural tube defectThese symptoms responded not at all first to 5 star and then very strongly to Metafolin with basics. Many started improving in hours. Some took 7 years to correct.lack of dreamingMCV > 100 outright macrocytosismacrocytic anemiametallic taste in mouthWidespread body & muscle pain responding to NSAIDJoint pain responding to NSAIDSsplits/sores at corners of mouth -angular cheilitisSexual related symptoms, both men and women – These responded with the most response to lesser responses in order to MeCbl, Metafolin (l-methylfolate), AdoCbl, L-carnitine fumaratereduced libido - loss of sexual desireloss of orgasmic intensityunsatisfying orgasmsinability to orgasmloss and/or change of genital sensationsburning genital skin sensationunable to feel arousednumb genital skinlow sex hormonesMENIn order of response – MeCbl, AdoCbllow testosterone menIn order of response – MeCbl, Metafolin, AdoCbl, L-carnitine fumarateerectile dysfunction menIn order of response – MeCbl, Metafolin, AdoCbllow sperm countpoor sperm motilityPoor sperm qualityno spermWOMENIn order of response – MeCbl, AdoCbllow testosteronelow estrogenIn order of response – MeCbl, Metafolin, AdoCbl, L-carnitine fumaratepost partum depressionpost partum psychosisIn order of response – MeCbl, Metafolin, AdoCblFrequent miscarriageIn order of response – MeCbl, MetafolinFalse positive pap smears, defective cellsmenstrual symptomsThese symptoms are what responded very well to CNS penetrating doses of MeCbl either as 50mg sublingual single 4-5 hour dose or 4 x 7.5mg or 3 x 10mg or for some 2 x 15mg subcutaneous MeCbl injections. Metafolin in some way enhances retention of AdoCbl and MeCbl with excretion visibly decreased. A sublingual dose of 1-2 tablets each hour added for 12 hours appears to generate substantial CNS penetration as well.CNS penetrating dose MeCbl – AdoCbl – Metafolin – Omega-3 oilsElevated CSF HcyLow CSF cobalaminlimbs feel stiffDrowsyCNS penetrating dose MeCbl – AdoCbldimmed vision - usually not noticed going into it because change can be very slow or present for lifeClumsinessCNS penetrating dose MeCbl – AdoCbl - MetafolinSlow to adapt to night visionCNS penetrating dose MeCbl – AdoCbl – Metafolin – LCFDifficulty in word findingCNS penetrating dose MeCbl – AdoCbl – Metafolin – Omega-3 oilsBrainstem or cerebellar signs or even reversible (with mb12) coma may occurdemyelinated areas on nervessubacute combined degenerationaxonal degeneration of spinal cordunsteadiness of gaitataxic gait, particularly in darkpositive Rombergpositive LhermittesLoss of motor control over some or all of toesLoss of motor control over part or all of feetLoss of sense of joint positionsudden electric like shocks/pains shooting down arms, body, legs shooting down from neck movementsudden "ice pick" paindecreased reflexesbrisk reflexesFoot Droptripping over toesinjuring toes catching top of toes on floorgeneral feeling of weakness12. Next 1 year titrating Metafolin and finding all the reasons I get folate insufficiency, early partial methylation block by effect.These symptoms are what responded very well to L-carnitine fumarate AND AdoCbl for the first two itemsL-carnitine fumarate – AdoCbl – Metafolin - MeCblweight loss involuntarymuscular atrophyexercise does not build muscleL-carnitine fumarate – Metafolin – AdoCbl - MeCblweight gain, watery fatedemaL-carnitine fumarate – AdoCbl – MeCbl – Metafolinmild to extremely severe fatiguecontinuous extremely severe fatigueeasy fatigabilitysevere abnormal muscle fatigue up to and including apparent paralysis leading to deathweaknessmuscle pain especially around attachment points to bonesEighteen severely tender muscle spots of FMSAdoCbl – L-carnitine fumarateexercise debilitates for up to a week, making things much worseaccumulating muscle pains following exertionsore muscles throughout bodylack of muscle recovery after exerciseHigh urinary MMAAdoCbl – L-carnitine fumarate – Metafolincongestive heart failureElevated CSF MMAElevated uMMAMeCbl - AdoCbl – L-carnitine fumarate – Metafolinshortness of breath, oxygen hungerheart palpitationsMeCbl - AdoCbl – L-carnitine fumarateextremely sore neck muscles reversing normal curvature of neckpainfully tight, stiff muscles, especially legs and armsfrequent muscle spasms anywhere in bodyweak pulseMeCbl - AdoCblConfusionDisorientationDifficulty in word findingMeCbl - AdoCbl - MetafolinirritabledepressionSAD - Seasonal Affective Disordermental slowingpersonality changeschronic malaisepoor concentrationmoodinesstirednessmood swingsmemory losslistlessnessimpaired connection to othersmentally fuzzy, foggy, brainfogdizziness - even unable to walkVertigoMeCbl – Metafolin – AdoCbl – L-carnitine fumaratepsychosis, including many of the most florid psychoses seen in literature, megaloblastic madnessAlzheimer'sdeliriumdementiaparanoiadelusionshallucinations - multisensoryanxiety or tensionnervousnessmaniaWidespread pain throughout bodyA caution, those with anxiety and panic symptoms may respond with extreme moods of increased fear, anxiety, panic, anger rage, homicidal rage and profound depression, usually in repeatable sequences following LCF or ALCAR even at levels of 1mg oral. A micro titration of carnitine would be cautious. While most find the moods intolerable, certain persons have been able to tolerate these (both past) and current, to find they can fade after some months of consumption. A few people may find similar, maybe somewhat lesser, response to MeCbl or more likely AdoCbl. As these are less controllable than LCF which can be micro dosed, they should be considered firstFollowing are the groups of induced deficiency symptoms when starting with the Deadlock Quartet (AdoCbl, MeCbl, Metafolin, L-carnitine fumarate).Version 2.44 08/08/2019 A work in process, incomplete, limited testing, people come in many variations, use at your own risk.Copyright 2019, Frederick D. Davis, aka Fred Davis, aka Freddd, copied from original manuscript.INDUCED DEFICIENCY SYMPTOMS FROM REFEEDING SYNDROME. This can follow 5 days of food deprivation, anorexia, or sort of a pinpoint starvation via vitamin or mineral or amino acid deficiencies. Whatever the “most needed” item is will often cause a strong response. The first usual notable symptoms occur on typically the third day of starting a previously insufficient nutrient with normally feeling or seeing the changes within minutes to hours. From MecBL I had over 30 symptoms respond in the first few hours with blow my socks off intensity with neurological startup and potassium deficiency on the 3rd day along with increasing folate deficiencies that took years to figure out. For instance it was noted in the 50s with injections of B12 with potassium deficiency (hypokalemia) as a side effect. It is dangerous and can be unpredictably fatal if not corrected and the cause is continued. When they say people are dying in Syria after they have been starved and given food, they are often suffering REFEEDING SYNDROME. When previous symptoms return that can also indicate a developing deficiency that started hindering cell formation.Group 1 – Hypokalemia onset. Often called “detox”. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (Cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.IBS – Steady constipation, Nausea, Vomiting, Paralyzed Ileum,Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weaknessAbnormal heart rhythms (dysrhythmias), increased pulse rate, increased blood pressure, intense sudden dizzy spells correctable potentially in minutes with water with potassium gluconate for instance.Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.Group 2a - Both hypokalemia and l-methylfolate deficiencyIBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipationGroup 2b – Either or both hypokalemia and l-methylfolate deficiencyHeadache, Increased malaise, FatigueGroup 3 - Induced and/or Paradoxical Folate deficiency or insufficiency, partial methylation block to methyltrap on 1 or more internal triage levels. Frequently called “NAC DETOX” or “GLUTATHIONE DETOX”. Can be caused by folic acid, folinic acid and for some people, like me and quite a few others, excess vegetable folates. Further excess B1, B2, B3 and/or inositol can increase methylfolate deficiency symptoms. Methylfolate, MeCbl and just about anything else that starts healing can cause the folate deficiency symptoms.These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.Old symptoms returning in a general sense, a person may have had onset of these hundreds of time if they are on the borderlineEdemaAngular Cheilitis, Canker sores,Skin rashes, increased acne, Increased itchy acne on scalp and face, Skin peeling around fingernails, Skin cracking and peeling at fingertips, painful cracks in the skin at the corner of fingernails at approximate right angles to nails, can take months to occur and it may be only non mood or neurological symptoms.IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipationHeadache, Increased malaise, FatigueIncreased hypersensitive responses, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptomsIBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract,Coated tongue, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Lightheadedness, Sluggishness, Increase irritability, Heart palpitations,Longer term, very serious:Loss of reflexes, Fevers, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, bleeding easily.High MCV, > 93, persistent and resistant to MeCbl and B6 and/P5P. The warning about too much folate causing subacute combined degeneration which kept folic acid to a max of 800 mcg for decades becasue large folate doses can lower MCV without MeCbl. There is a long history to this.Group 4 - HyCbl onset, degraded MeCbl onset, MeCbl after photolytic breakdown onset.Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.Group 5 – Copper deficiency after methylation startup has been achieved which often starts refeeding syndrome. 50mg or more of zinc has been indicated as a possible cause. 200-400 mg of zinc has been linked to copper deficiency. Excess supplemental or environmental manganese is linked to copper deficiency. Any or all symptoms can occur at “low normal range” copper tests. Well after all other observable copper deficiency symptoms showed up, a lower value as copper contibued to fall, MCV suddenly went over 100 after it had fallen toDemyelination of nerves similar to Sub Acute Combined Degeneration except that methylation and ATP startup has occurred, and copper deficiency favors damage to the upper motor neurons with perceived muscle weakness. Brittle nails. Sleep disorders. Mood (especially depression perhaps) and personality changes. Connective tissue breakdown. Spider veins. Varicose veins. Shrinking gums. Gum disease not responsive to usual measures. Unstoppable tooth decay on exposed areas without enamel. Low testosteroneGroup 6 – Excess P-5-P, an active form of B6 that appears to drive hematocrit.High hematocrit. The blood thickens and doesn’t pump as easily. Deep vein thrombosis can result. Other suspected circulatory hazards. Sometimes linked to high testosterone when lowering P-5-P might reduce it.Group 7 – Excess B-vitamins affecting methylationWhen taking the active B12/folate deadlock quartet (AdoCbl, MeCbl, Metafolin, L-methylfolate) Excess B1 - Thiamin, Excess B2 – Riboflavin, Excess B3 – Niacin and/or Excess Inositol can all produce an excess need for potassium to deal with Groups 1, 2a and 2b symptoms and/or produce an excess need for l-methylfolate to reduce groups 2a, 2b and 3 symptoms. A person might not be able to correct by taking potassium or folate and may need to reduce B1 <= 15mg/day, B2<= 10.2mg/day, B3 <=50mg, and inositol below an unknown quantity.Group 8 – Boron insufficiency.Arthritis swelling and pain, can be reduced by BoronContribution to fatigue, neurological effectsFormation of bacterial filmsRunaway tooth decay,vaginal bacterial filmsLoss of calcium in bones and teeth15 Surprising Benefits of BoronAlthough all of the deficiency symptoms of boron are not fully understood, it is known that boron deficiency might result in the abnormal metabolism of calcium and magnesium. Some of the other symptoms include hyperthyroidism, sex hormone imbalance, osteoporosis, arthritis and neural malfunction.Group 9 - Vanadium insufficiencyDeficiency of vanadium is poorly known or recognized. It affects tissue permeability like insulin.vanadium insufficiency can cause (allow?) rising AICvanadium insufficiency allows the liver to make more cholesterolGroup 10 - MolybdenumThe best indicator symptoms appear to be the copper deficiency symptoms and it appears to go induced deficient at about the same rate.Group 11 - Lithium insufficiency Non ionizing forms, small micronutrient doses1 - TCR-Li is somehow connected and that mass quantities of MeCbl penetrating the CNS enough to heal doesn’t do, cause the body homeostasis system to function along with the often mentioned “body healing triage”. It doesn’t seem to work until reaching a threshold of TCR-Li is achieved. I have never had stable electrolytes before in my life. I do now. For 17 years I have had merry go round refeeding syndrome. I don’t anymore. Things became stable. I had hypokalemia only when I really am low. It used to happen every two weeks and each time I added another nutrient or increased it. The bottlenecks are prevented most of the time it appears.2 - With TCR-Li with some brands of MeCbl tablets, People who have some TCR-Li remaining have a five minute mouth to brain response but don’t have enough TCR-Li in the CNS to retain the B12. In a Japanese trial of 2.5mg CSF MeCbl injection, the subjects had neurology improvement for as long as the MeCbl lasted. The study showed some couldn’t retain it 3 months and other retained the MeCbl 4 years or longer. I no longer take 3x10mg a day of MeCbl injections. Now I take 1 7.5mg sc injection once per week or longer. My nervous system now stores B12 for nearly 2 weeks now and increasing as I take it longer. My TCR-Li seems to be still increasing.3 - After nearly 4 years of Li I had a dramatic shift. For 17 years If I injected MeCbl, 7.5mg or more for CNS effectiveness, would be excreted in urine, much within 1 hour of injection. With folic acid, 2.4 mg sc was visible in urine in one hour. With Methylfolate, 4.2 mg was visible in urine in one hour. With TCR-Li in my kidneys suddenly 10 mg sc injection was not visible at all until 4 hours to 18 hours depending upon other considerations and might be spread over 8–12 hours instead of visible for 1-2 hours and other times a lot of B12 is held back completely and then comes out in one big load.4 - People deficienct of TCR-Li have poor homeostasis and hardly functional internal triage. People with reasonably fully functional TCR-Li have functioning homeostasis and internal triage.5 - The CNS TCR-Li appears to protect the CNS from damage from methyltrap caused by CyCbl, HyCbl, AdoCbl if replacing the mandatory MeCbl in position that requires either MeCbl or cob[ii]. The TCR-Li is said to be able to strip the ligand from all varieties of B12 and supply the CNS with cob[ii], the catalytic B12 that works everywhere. Without TCR-Li I had AdoCbl and MeCbl responses that were different in both body and CNS. With TCR-Li I get identical effects from AdoCbl and MeCbl in CNS and still some differences in body. Haptocorrin is said to be very fussy what cobalamin it protects and transports.6 - Without TCR-Li the balance between AdoCbl and MeCbl can affect mood and personality. Too much AdoCbl and a person was more having too much methyltrap and person would be very irritable and with the balance towards MeCbl mood is better and person is less irritable. It can change suddenly and can be severe. There may be a couple of hundred high resolution difficult to describe neuropsych symptoms. With enough TCR-Li and B12 and cofactors many of these things can resolve in hours to a year or more.Group 12 - Iodine insufficiency, especially needed for those who don't eat iodized table salt and/or seafood.Group 13 - L-carnitine XXXXX, That can be L-carnitine tartrate, L-C Fumarate, L-C freebase, ALCAR and others but usually works only one kind at a time.neuromuscular pain, feeling of growing inflammation, fatigue, mood changes, sleep problems. These are quick occurring symptoms and they can spread to the complete 4 way deadlock over time.It appears that for most people in this refeeding situation many may respond to only one form of l-carnitine, initially fumarate or ALCAR and sometimes also including a freebase form. However, as the deficienciencies change, the pathways appear to change and the carinitne that worked so well no longer does and the form is some entirely different one, like tartrate or some other variation. A person may need to trial half a dozen forms. A response is usually clear the first day or occasionally several days with micro doses and titration. And it can change based on what else is corrected.Fred Davis's answer to Has someone used a MeCbl treatment for patients or has been treated with MeCbl? What for and what were the outcomes?