Form 433-B (Rev: Fill & Download for Free

GET FORM

Download the form

How to Edit and draw up Form 433-B (Rev Online

Read the following instructions to use CocoDoc to start editing and finalizing your Form 433-B (Rev:

  • Firstly, direct to the “Get Form” button and press it.
  • Wait until Form 433-B (Rev is appeared.
  • Customize your document by using the toolbar on the top.
  • Download your finished form and share it as you needed.
Get Form

Download the form

The Easiest Editing Tool for Modifying Form 433-B (Rev on Your Way

Open Your Form 433-B (Rev Without Hassle

Get Form

Download the form

How to Edit Your PDF Form 433-B (Rev Online

Editing your form online is quite effortless. You don't need to download any software on your computer or phone to use this feature. CocoDoc offers an easy application to edit your document directly through any web browser you use. The entire interface is well-organized.

Follow the step-by-step guide below to eidt your PDF files online:

  • Browse CocoDoc official website on your computer where you have your file.
  • Seek the ‘Edit PDF Online’ icon and press it.
  • Then you will open this tool page. Just drag and drop the PDF, or import the file through the ‘Choose File’ option.
  • Once the document is uploaded, you can edit it using the toolbar as you needed.
  • When the modification is completed, tap the ‘Download’ option to save the file.

How to Edit Form 433-B (Rev on Windows

Windows is the most conventional operating system. However, Windows does not contain any default application that can directly edit template. In this case, you can download CocoDoc's desktop software for Windows, which can help you to work on documents efficiently.

All you have to do is follow the steps below:

  • Install CocoDoc software from your Windows Store.
  • Open the software and then append your PDF document.
  • You can also append the PDF file from URL.
  • After that, edit the document as you needed by using the varied tools on the top.
  • Once done, you can now save the finished paper to your device. You can also check more details about how to alter a PDF.

How to Edit Form 433-B (Rev on Mac

macOS comes with a default feature - Preview, to open PDF files. Although Mac users can view PDF files and even mark text on it, it does not support editing. Thanks to CocoDoc, you can edit your document on Mac quickly.

Follow the effortless guidelines below to start editing:

  • In the beginning, install CocoDoc desktop app on your Mac computer.
  • Then, append your PDF file through the app.
  • You can upload the template from any cloud storage, such as Dropbox, Google Drive, or OneDrive.
  • Edit, fill and sign your template by utilizing some online tools.
  • Lastly, download the template to save it on your device.

How to Edit PDF Form 433-B (Rev through G Suite

G Suite is a conventional Google's suite of intelligent apps, which is designed to make your work more efficiently and increase collaboration within teams. Integrating CocoDoc's PDF editing tool with G Suite can help to accomplish work handily.

Here are the steps to do it:

  • Open Google WorkPlace Marketplace on your laptop.
  • Look for CocoDoc PDF Editor and get the add-on.
  • Upload the template that you want to edit and find CocoDoc PDF Editor by selecting "Open with" in Drive.
  • Edit and sign your template using the toolbar.
  • Save the finished PDF file on your laptop.

PDF Editor FAQ

Is there a simple explanation of the Louvain Method of community detection?

TL;DR/Short version: Communities are groups of nodes within a network that are more densely connected to one another than to other nodes. Modularity is a metric that quantifies the quality of an assignment of nodes to communities by evaluating how much more densely connected the nodes within a community are compared to how connected they would be, on average, in a suitably defined random network. The Louvain method of community detection is an algorithm for detecting communities in networks that relies upon a heuristic for maximizing the modularity. The method consists of repeated application of two steps. The first step is a "greedy" assignment of nodes to communities, favoring local optimizations of modularity. The second step is the definition of a new coarse-grained network in terms of the communities found in the first step. These two steps are repeated until no further modularity-increasing reassignments of communities are possible. The Louvain method achieves modularities comparable to pre-existing algorithms, typically in less time, so it enables the study of much larger networks. It also generally reveals a hierarchy of communities at different scales, and this hierarchical perspective can be useful for understanding the global functioning of a network. Meanwhile, there are certain pitfalls to interpreting the community structure uncovered by the Louvain Method; these difficulties are actually shared by all modularity optimization algorithms.I strongly recommend reading the original paper on the Louvain method [1]. It's fairly short, easy to read, and will give you a solid understanding of the algorithm. Incidentally, one of the originators of the Louvain Method (Renaud Lambiotte) seems to have a Quora account; it would be awesome to get his perspective on recent developments and applications.Long version: Below, I'm going to give my own description of the Louvain method. To hopefully not be too redundant with the original paper, I'm going to also focus on background, context, applications, and follow-up work. Covering all that ground makes this answer pretty lengthy, so please just skip to the sections that interest you. In particular, if you're familiar with the problem of community detection and the role of modularity in community finding algorithms, you can skip to the Louvain method section below.Also, before I begin, I'll point out that my discussion will exclusively consider the case of undirected, but possibly weighted, links. The Louvain method has been extended to the directed case, so interested readers should seek out the relevant literature.Motivating the Problem of Community DetectionA fairly common feature of complex networks is that they consist of sets of nodes that interact more with one another than with nodes outside the set. Social networks, for instance, might consist of tightly knit communities of friends with rarer friendship ties between different communities. In protein interaction networks, certain groups of proteins interact with one another more frequently than they do with proteins in other groups. If you map out a network of projects going on in a large company, certain projects will likely have more conceptual overlap and mutual dependency than others; this network structure will hopefully be mirrored to some degree by the organizational structure within the company.In 1962, H.A. Simon proposed that this type of community structure might be a defining characteristic of complex systems, or at least those like the protein interaction network, in which many interacting constituent elements adaptively organize to achieve some higher-order function (e.g., the functioning of an organism). His reasoning was that individual actors have a much higher chance of collectively achieving a higher-order function if that function can be iteratively achieved by constructing intermediate stable forms (also called communities or modules) that achieve simpler functions. The first-order intermediate forms would be communities in terms of the original nodes, but then interactions between these first-order communities could generate second-order communities that accomplish somewhat more complicated functions, and so on. In this way, a hierarchical structure can emerge in complex adaptive systems [2]. However, even when there isn't necessarily adaptive pressure towards achieving some higher-order function (as in the case of some social networks), community structure is a common observed feature of complex networks.When we're handed a data set describing a network, we typically don't know what the underlying community structure is. We often don't even know how many first-order communities we should be looking for, let alone how many hierarchical levels of communities we should consider. Meanwhile, for the reasons given above, the community and hierarchical structures are often very useful for understanding the overall functioning of the complex system. This motivates the search for good community detection algorithms.Definition of ModularityOne popular class of community detection algorithms seeks to optimize the so-called modularity of the community assignment. Modularity is a metric that was proposed by Newman and Girvan in reference [3]. It quantifies the quality of a community assignment by measuring how much more dense the connections are within communities compared to what they would be in a particular type of random network.There are two mathematical definitions of modularity that you'll frequently encounter. The first is the one used in the original paper on the Louvain method [1]:[math]Q = \frac{1}{2m} \sum_{i,j} \left[A_{ij} - \frac{k_i k_j}{2m}\right] \delta(c_i, c_j)[/math]Here, [math]A[/math] is the usual adjacency matrix, [math]k_i = \sum_j A_{ij}[/math] is the total link weight penetrating node [math]i[/math], and [math]m = \frac{1}{2}\sum_{i,j} A_{ij}[/math] is the total link weight in the network overall. The Kronecker delta [math]\delta(c_i, c_j)[/math] is [math]1[/math] when nodes [math]i[/math] and [math]j[/math] are assigned to the same community and [math]0[/math] otherwise. Consider one of the terms in the sum. Remember that [math]k_i[/math] is the total link weight penetrating node [math]i[/math], and note that [math]\frac{k_j}{2m}[/math] is the average fraction of this weight that would be assigned to node [math]j[/math], if node [math]i[/math] assigned its link weight randomly to other nodes in proportion to their own link weights. Then, [math]A_{ij} - \frac{k_i k_j}{2m}[/math] measures how strongly nodes [math]i[/math] and [math]j[/math] are in the real network, compared to how strongly connected we would expect them to be in a random network of the type described above.The other definition of modularity that you'll see is the one proposed in the paper by Newman and Girvan [3]. They defined a matrix (let's call it [math]B[/math], though Newman and Girvan used the symbol [math]e[/math]), where [math]B_{c_1 c_2}[/math] denotes the fraction of all edge weight in the network that connects community [math]c_1[/math] to community [math]c_2[/math]. They also defined [math]W_{c_1} = \sum_{c_2} B_{c_1 c_2}[/math] as the total edge weight penetrating community [math]c_1[/math]. Then, they defined the modularity as:[math]Q = \sum_{c} \left[B_{cc} - W^2_c\right][/math]It's pretty easy to show that this definition is equivalent to the one from the Louvain method paper, but I won't write out the steps here.Modularity Optimization AlgorithmsReturning to the first definition of modularity above, the problem of modularity optimization can be thought of as assigning communities such that the elements of the sum that contribute are as positive as possible (remember that the delta function kills terms in the sum corresponding to pairs of nodes that belong to different communities). The problem is that you can have situations where it makes sense to put nodes [math]1[/math] and [math]2[/math] in the same community and to put [math]2[/math] and [math]3[/math] in the same community, but where [math]A_{13} - \frac{k_1 k_3}{2m}[/math] is very negative, indicating that nodes [math]1[/math] and [math]3[/math] really shouldn't be in the same community. This is a simple example of a kind of frustration that makes the modularity optimization problem really hard.Indeed, the modularity optimization problem is actually NP-hard, and that has motivated searches for heuristic approaches that typically do a good job at finding high modularity community assignments with more scalable complexity [1]. The modularity maximization algorithms that I'm aware of typically fall into one the following categories [3]:agglomerative: where you iteratively group nodes into communitiesdivisive: where you progressively remove links from the network, and the depleted network reveals good community assignmentssimulated annealing: where you introduce an artificial "temperature" and perform Metropolis-like Monte Carlo updates while gradually lowering the temperature. Here, you take [math]-Q[/math] to be the energy function for the system. The proposed moves can consist of both agglomerative and divisive steps [4]spectral: where an eigenvector of the so-called modularity matrix encodes the community structureIn their original 2003 modularity paper [3], Newman and Girvan proposed a divisive algorithm for modularity optimization. The intuition behind their algorithm can be motivated by the following diagram:To the naked eye, it's obvious that this network consists of two densely connected communities that are only linked to one another by the single link connecting nodes [math]5[/math] and [math]12[/math]. That link has been highlighted in blue to emphasize the special role it plays. If that single link were to be cut, it would completely decouple the two communities. A metric that distinguishes the blue link from the others is the edge betweenness centrality. That link lies on all geodesic paths from the community on the left to the community on the right, so it will have the highest betweenness centrality of any edge in the graph. More generally, edges with high betweenness will tend to be those that link communities rather than those that connect nodes within communities. Therefore, Newman and Girvan proposed iteratively removing the edges with the highest betweenness centralities. After each removal, the betweenness of all the edges needs to be recomputed to figure out which edge to remove next. The procedure can be stopped at any point, with the connected components of the edge-depleted graph giving the communities. You can continue the Newman-Girvan procedure until the network is fully depleted, computing the modularity of the community assignment at each step, and ultimately choosing the intermediate step that maximized the modularity. This process takes time [math]O(N_n N^2_{\ell})[/math], where [math]N_n[/math] is the number of nodes and [math]N_{\ell}[/math] is the number of links in the network. If the networks under consideration are sparse so that [math]N_{\ell} \propto N_n[/math], this algorithm is [math]O(N^3_n)[/math]Between 2003 (when the Newman-Girvan paper came out) and 2008 (when the Louvain method was proposed), several faster modularity optimizing algorithms were proposed by:Clauset, Newman, & Moore (CNM) [5]Pons and Latapy (PL) [6]Wakita and Tsurami (WT) [7]All of these methods are agglomerative, some of them run in close to linear time (in the number of nodes, or by the assumption of sparsity, in the number of links) on sparse networks, and it was these methods that the Louvain method's originators benchmarked their algorithm against (see the table at the end of the next section).Louvain Method of Community DetectionNow, I'm going to illustrate how the Louvain Method works by applying it to a "connected caveman graph." This is a network where you begin with [math]N_{cl}[/math] fully-connected cliques of [math]M[/math] nodes each. Next, you arrange these cliques in a circle. Then, you take one random link from each clique and rewire it so that the clique is connected to its nearest clockwise neighbor. You do this once for each clique, and you end up with something that looks like this:All links in this initial network have unit weight. This is the test network with which we'll explore the Louvain Method below. The "intuitive partition" here consists of the six communities of five nodes each that we've put in by hand.At the beginning of the Louvain Method, we assign each node to its own community, so in the connected caveman network above, there are 30 initial communities, each containing one node.Stage 1: Community ReassignmentsIn the first stage of the Louvain Method, we iterate through each of the nodes in the network. For each node, we consider the change in modularity if we remove the node from its current community and place it in the community of one of its neighbors. We compute the modularity change for each of the node's neighbors. If none of these modularity changes are positive, we keep the node in its current community. If some of the modularity changes are positive, we move the node into the community for which the modularity change is most positive. Ties can be resolved arbitrarily. We repeat this process for each node until one pass through all nodes yields no community assignment changes.For the initial connected caveman graph, we can figure out what will happen in the first few steps of this community reassignment change by hand. In my implementation of the Louvain Method, the first node considered was [math]29[/math], which is connected to nodes [math]25[/math]-[math]28[/math]. If we were to merge nodes [math]25[/math] and [math]29[/math] into the same community, that would correspond to activating the terms [math]A_{25,29} - \frac{k_{25} k_{29}}{2m}[/math] and [math]A_{29,25} - \frac{k_{25} k_{29}}{2m}[/math] in the sum above. Each of these have value [math]1 - \frac{25}{120} = \frac{19}{24}[/math]. So performing the community reassignment will boost the modularity by [math]\frac{19}{12}[/math]. Actually, all of the proposed mergers for node 29 will have this same modularity boost, so we can accept any one of them. My implementation assigns node [math]29[/math] to the same community as node [math]25[/math] and then moves on to consider another randomly selected node.Actually, in the initial graph, merging any pair of neighboring nodes will increase modularity by the amount that I calculated in the previous paragraph. In particular, this will be true even for pairs like nodes [math]10[/math] and [math]8[/math], which intuitively belong to different communities. This means that, in the initial stages of the community reassignment phase, pairs of nodes like this have a possibility of being assigned to the same community. It's an instructive exercise to think through how mistakes like this are remediated as the community reassignment stage progresses, and I encourage you to do so.Here are the community assignments that my implementation of the Louvain Method finds after the first community identification stage:As you can see, the algorithm has already discovered the "intuitive" communities, which is unsurprising, since this is a rather simple network.Stage 2: Coarse GrainingThe next stage in the Louvain Method is to use the communities that were discovered in the community reassignment stage to define a new, coarse-grained network. In this network, the newly discovered communities are the nodes. The edge weight between the nodes representing two communities is just the sum of the edge weights between the constituent, lower-level nodes of each community. The links within each community generate self-loops in the new, coarse-grained network.In the simple connected caveman network that we're studying, there's only one, unit-weight link connecting neighboring communities, so the links between the coarse-grained communities also have unit weight. If there were two or more links between communities, the new coarse-grained link would have weight equal to the sum of all the lower-level links. Meanwhile, within each community, there are [math]\frac{5 \times 4}{2} - 1 = 9[/math] unit-weight links, so the self-loops have weight [math]9[/math]. Here's what the coarse-grained network will look like:In this graph, the black numbers associated with the links indicate edge weights, but the white numbers on the nodes are just labels for the communities. As a side note, I had to draw in the self-loops by hand because NetworkX, while generally an awesome Python package for doing these types of analyses, doesn't appear to draw them.If you're writing your own implementation of the Louvain Method, you'll want to be careful about how you're assigning the diagonal matrix elements of the adjacency matrix (corresponding to the self-loops). To be able to consistently apply the modularity formulae above, you actually want to double the diagonal matrix elements. This means that, for the graph above, the diagonal elements will be [math]18[/math]. It's worth thinking through why this choice is appropriate for preserving the interpretation of modularity that I mentioned above. A good consistency check for debugging your implementation is that, when you construct your coarse-grained network, [math]m = \frac{1}{2}\sum_{i,j} A_{ij}[/math] shouldn't change.Repeated Iteration of Stages 1 and 2The rest of the Louvain Method consists of repeated application of stages 1 and 2. By applying stage 1 (the community reassignment phase) to the coarse-grained graph, you find a second tier of communities of communities of nodes. Then, in the next application of stage 2, you define a new coarse-grained graph at this higher-level of the hierarchy. You keep going like this until an application of stage 1 yields no reassignments. At that point, repeated application of stages 1 and 2 will never yield any more modularity-optimizing changes, so the process is complete.For the connected caveman graph, the process terminates on the second community reassignment stage. We can see why if we propose a merger of two communities in the coarse-grained graph above. This would result in a modularity change of [math]2 * \left[1 - \frac{20*20}{120}\right] = -\frac{14}{3}[/math], so no merger will be accepted. As an exercise, I'd encourage you to think about what happens if the original caveman graph had more than [math]20[/math] cliques. You can work this out analytically, or you can implement the Louvain Method yourself and test it out. My own implementation of the Louvain Method took less than 200 lines of Python code, and I'm not particularly good at keeping my Python code (or my Quora answers) brief. Working through the 21-clique test case, whether you do it analytically or numerically, will give you some intuition for the final section of this answer: "Possible Pitfalls of Modularity Maximization."In the original paper on the Louvain Method, the authors benchmarked their new algorithm against some of the other modularity optimization algorithms that I mentioned above. Here's a table from the paper showing that the Louvain Method achieved similar modularities in typically faster time [1]:Real-World Applications of the Louvain MethodOne of the applications reported in the original Louvain Method paper was a study of a large Belgian phone call network in which nodes represented customers and weighted links represented the number of phone calls between two customers over a six-month period. The network had 2.6 million nodes and 6.3 million links. The Louvain Method revealed a hierarchy of six levels of communities. At the top level of this hierarchy, the communities representing more than 10,000 customers were strongly segregated by primary language. All except one of these communities had an 85% or greater majority of either French or Dutch speakers. The sole community with a more equitable distribution was positioned at the interface between French and Dutch clusters in the top-level coarse-grained network. Here's what the authors had to say about this community [1]:These groups of people, where language ceases to be a discriminating factor, might possibly play a crucial role for the integration of the country and for the emergence of consensus between the communities. One may indeed wonder what would happen if the community at the interface between the two language clusters... was to be removed.Since 2008, the Louvain Method has found a wide range of applications in analyzing real-world networks. Several of these can be found on the "official website" for the method:analysis of online social networks like Twitter, LinkedIn, Flickr, Youtube, and LiveJournalanalysis of collaboration communities in citation networksanalysis of a network of retail transactionsOne application that I want to call out independently, just because I found it particularly interesting, is the study of brain networks using the Louvain Method [9]. This is pretty far outside my expertise, so I won't pretend to understand all the details, but the authors of that study found similar community structure across the brains of 18 different people and modules that made sense from a functional perspective.Possible Pitfalls of Modularity MaximizationThe Louvain Method, and modularity optimization algorithms more generally, have found wide application across many domains. However, fundamental problems with these algorithms have also been identified. To close out this answer, I want to discuss some of these difficulties. Here's a quick introduction to two:The "resolution" limit: If you worked out the 21-clique caveman graph example that I suggested above, you would have noticed that for larger networks, the Louvain Method doesn't stop with the "intuitive" communities. Instead, there's a second pass through the community modification and coarse-graining stages, in which several of the intuitive communities are merged together. This is unfortunately a general problem with modularity optimization algorithms. They have trouble detecting small communities in large networks. It's a virtue of the Louvain Method that something close to the intuitive community structure is available as an intermediate step in the process.The "degeneracy" problem: There are typically an exponentially large (in network size) number of community assignments with modularities close to the maximum. This can be a severe problem because, in the presence of a large number of high modularity solutions, it's (a) hard to find the global maximum and (b) difficult to determine if the global maximum is truly more scientifically important than local maxima that achieve similar modularity. Good et al. showed that the different locally optimal community assignments can have quite different structural properties [10].These problems are discussed and studied at length in reference [10]. The authors of that paper concluded with this cautionary note about modularity maximization:...modules identified through modularity maximization should be treated with caution in all but the most straightforward cases. That is, if the network is relatively small and contains only a few non-hierarchical and non-overlapping modular structures, the degeneracy problem is less severe and modularity maximization methods are likely to perform well. In other cases, modularity maximization can only provide a rough sketch of some parts of a network's modular organization.References[1] V.D. Blondel et al. Fast unfolding of communities in large networks. J. Stat. Mech. P10008 (2008).[2] H.A. Simon. The Architecture of Complexity. Proceedings of the American Philosophical Society. 106-6: 467 (1962).[3] M.E.J. Newman and M. Girvan. Finding and evaluating community structure in networks. Phys. Rev. E. 69: 026113 (2004).[4] R. Giumerà and L.A.N. Amaral. Functional cartography of complex metabolic networks. Nature. 433: 895 (2005).[5] A. Clauset, M.E.J. Newman, and C. Moore. Finding community structure in very large networks. Phys. Rev. E 70, 066111 (2004).[6] P. Pons and M. Latapy. Computing communities in large networks using random walks. Journal of Graph Algorithms and Applications. 10: 191 (2006).[7] K. Wakita and T. Tsurami. Finding Community Structure in Mega-scale Social Networks. arXiv: 0702048 (2007).[8] V.D. Blondel. Louvain method website.[9] D. Meunier et al. Hierarchical Modularity in Human Brain Functional Networks. Frontiers in Neuroinformatics. 3: 37 (2009).[10] B.H. Good, Y-A de Montjove, A. Clauset. The performance of modularity maximization in practical contexts. Phys. Rev. E 81, 046106 (2010).

What is the birthday gift I can give to my best friend who is a bibliophile?

How about one of these?An Annotated Bibliography of Typography, Letterpress Printing and Other Arts of the Bookby David S. Rose • Five Roses PressThe explosion of desktop-based, digital pre-press technology at the end of the twentieth century brought to a wide audience the previously specialized world of typography. Modern type design applications give users the ability to create new digital typefaces from the imagination, to recreate classic faces that are otherwise unavailable in digital form, and to adapt existing faces for specific needs.For those artisans who still hand-set and print with traditional letterpress technology, a dozen type foundries continue to provide a constant stream of classic metal faces. And for designers who combine the two worlds by printing letterpress from photopolymer plates, the options are unlimited.As with any powerful tools, the more one knows of the history behind them, the better able one will be to utilize them. The books listed here are just a few of hundreds that have been written on the subject of typography over three centuries, but they will provide a solid start for reading in this area.While many of the works listed are classics in the field, not all of them are currently in print. Those that are not available from the publisher (or from reprint houses such as Dover Publications) may often be found at antiquarian dealers who specialize in the field of Books about Books. A number of such dealers are listed at the end of this bibliography, and the rapid adoption of the Internet by antiquarian book dealers now means that most of these books are a simple click away.Overviews of Printing TypesPrinting Types: An Introduction by Alexander Lawson with Dwight Agner [Boston: Beacon Press, 1990] is a short (120 pages) easy-to-read overview that is exactly as advertised: an introduction. For over thirty years, Lawson has taught a course in the history of printing types at the Rochester Institute of Technology School of Printing, and this book grew out of his need for a simple handbook on the subject for his students. It is a well designed and illustrated inexpensive paperback, and would probably be your best bet if you have a casual interest in the subject and only want to read one book. The latest edition, brought current through 1990, covers electronic typography as well.Printing Types: Their History, Forms, and Use by Daniel Berkeley Updike (1860-1941) [New York: Dover, 1980 reprint of the second (1937) edition]. This is the classic work in the field of typographic history. Updike was a leader in the revival of traditional printing typefaces in the United States, and was the founder of the Merrymount Press (1893). A series of lectures he gave at Harvard from 1910-1917 served as the basis for Printing Types, which was first published in 1922. This Dover reprint is in two volumes, 618 pages of text plus 300 unnumbered illustrations. As Dover says in the jacket notes, "Printing Types presents the standards, the landmarks in typography that anyone connected with printing must know. In its mammoth, illustrated coverage, it is without a doubt the definitive guide to the subject.Letters of Credit: A View of Type Design by Walter Tracy [Boston: David Godine, 1986. 224 p, ill.] A beautiful and profusely illustrated step-by-step demonstration of type-design aesthetics that traces the beginnings and the path of modern-day typesetting.Fine print on type; the best of Fine print magazine on type and typography by Charles A. Bigelow, Paul Hayden Duensing, Linnea Gentry [San Francisco: Fine Print: Bedford Arts, 1988] is an excellent selection of articles from Fine Print magazine, the late indispensable periodical with which anyone concerned with type should be familiar. Each issue was designed by a different typographer, printed by letterpress and included scholarly articles, typographic overviews, reviews, and notices of new books on typography. Fine Print was published quarterly through about 1990, after which the publication led cliff-hanging existence as various groups and institutions tried to save it. While long gone, a final retrospective index is currently nearing production, and will also be a must-get.Typographical periodicals between the wars; a critique of the Fleuron, Signature, and Typography by Grant Shipcott [Oxford: Oxford Polytechnic Press, 1980. xiv, 111 p. :ill.]. These classic periodicals (particularly the Fleuron) were to their time what Fine Print was to typography and book design today, but because of the ferment in the world of design during the 20s and 30s and because of their illustrious contributors, they had a much greater effect on the typography of the time.Type and Typefaces by J. Ben Lieberman [New Rochelle: The Myriade Press, 1978] is an alternative to the Lawson book, but rather less accurate, bigger (142 pages, 8 1/2 x 11, hardcover) and harder to find. Ben Lieberman was an enthusiastic amateur printer and the father of the American Chappel movement of hobby printers. This book is an exuberant look at the history, classification, identification, and personalities of typography. It includes examples of over 1,000 type faces, and is well illustrated. Lieberman was not a scholar, but if you like unabashed 'boosterism,' you might find this book fun to read, despite its errors of both omission and commission.History and Development of Lettering and Letter formsThe 26 Letters by Oscar Ogg [New York: Thomas Y. Crowell, 1948]. A nicely done book by a well known American calligrapher, tracing the evolution of the alphabet from prehistoric times to the invention of printing. 250 pages, well illustrated.Letters by James Hutchinson [New York: Van Nostrand Reinhold, 1983]. A stylishly designed, very readable history of alphabets, writing, and printing types.The History and Technique of Lettering by Alexander Nesbitt [New York: Dover Publications, 1957]. A thorough history of type design from its origin through the mid-twentieth century, this book covers some of the same material as the Ogg book, but includes much more information on the development of letter forms since the invention of printing. It is written from an artist's perspective, and has a how-to section on lettering.The Alphabet and Elements of Lettering by Frederic W. Goudy [New York: Dover Publications, 1963. Reprint of 1952 University of California edition]. This falls somewhere between the Ogg and Nesbitt books, from Goudy's unique perspective as the most prolific type designer of the twentieth century.Roman Lettering by L.C. Evetts [New York: Taplinger, 1979] includes a character-by-character analysis of the letters on Trajans Column in Rome, which have served for centuries as one of the foundations of roman (serif) letter design. Evetts also includes charts showing the evolution of the roman alphabet through the centuries. Handsome lettering, with little text to clutter the presentation.An ABC Book: ABC of Lettering and Printing Types by Erik Lindegren [New York: Pentalic, nd ca. 1976]. A survey of type, calligraphy, and design, with examples of work from all periods, with an especially strong representation of lettering by Swedish, English, German, and American scribes and designers. A lively, well-designed introduction to letters.Writing, Illuminating and Lettering by Edward Johnston [New York: Taplinger, 1980]. The comprehensive calligraphy manual by the man who led the twentieth century revival of calligraphy. Johnston's influence on English, American and German lettering and design was immense.History of Lettering by Nicolete Gray [Boston: David Godine, 1987. 256 p].Type Designs from Various PeriodsArt of the Printed Book, 1455-1955; masterpieces of typography through five centuries from the collections of the Pierpont Morgan Library, New York by Joseph Blumenthal, (1897- ) [New York: Pierpont Morgan Library; 1984. Boston, MA: D.R. Godine, xiv, 192 p. : ill.]. Available both in hardcover and paperback, this collection by one of the great printer/scholars of the century is a must have for anyone interested in original source material. More than a hundred full pages facsimiles from the Morgan Library provide an instant overview of the development of typographic design from Gutenberg to the mid-twentieth century.Anatomy of a Typeface by Alexander Lawson [Boston: David R. Godine, 1990, 428 pages] A great book from one of the leading typographic experts of the late twentieth century, this substantial work examines a wide variety of typefaces in great detail, and explains why they look the way they do. An excellent reference work for the designer and printer that will both improve your eye for the detail of font design and inform the choices you will make in specifying and setting type yourself.Selected Essays on Books and Printing by A. F. Johnson [Amsterdam: Van Gendt, 1970]. Johnson was a scholar at the British Museum, and along with Daniel Berkeley Updike and Stanley Morrison was considered one of the experts in the field of typographic history. This lovely, massive (500 pages), and very expensive collection of some of his writings from 1927-1957 concentrates primarily on the typographic work of sixteenth century calligraphers and printers.A view of early typography up to about 1600 by Harry Carter [(The Lyell lectures 1968) Oxford, Clarendon P., 1969. xii, 137 p. 45 plates. illus., facsims., col. map].A history of the old English letter foundries; with notes, historical and bibliographical, on the rise and fall of English typography by Talbot Baines Reed, 1852-1893 and A. F. Johnson [Folkestone: Dawsons, Reissued 1974 xiv, 400 p., fold. leaf : ill., facsims].Notes on a Century of Typography at the University Press, Oxford, 1693-1794 by Horace Hart [Oxford, Clarendon Press, Reissued 1970 (1st ed. of 1900 reprinted) with an introduction and additional notes by Harry Carter. ix, 16, xvi, 203 p., plate. illus. facsims]. History of the types and typography of the Oxford University Press, generally regarded as the preeminent scholarly press in the western world.Nineteenth Century Ornamented Type Faces by Nicolete Gray [Berkeley: University of California Press, 1976]. Reprint of a classic from 1938, this large format 240 page work is the definitive book on its subject.American Wood Type, 1828-1900 by Rob Roy Kelly [New York: Da Capo Press]. Notes on the evolution of decorated and large wood types, and comments on related trades. As with the Nicolete Gray book, this is the definitive work in its field. The book was issued in several editions, of which this (paperback) is the least expensive.The Typographic Book 1450-1935 by Stanley Morrison and Kenneth Day [Chicago: University of Chicago Press, 1963]. A lush, expensive, visual treasury of almost 500 years of typography, including 357 plates.American typography today by Rob Carter [(New York: Van Nostrand Reinhold, 1989. 159 p. : ill. (some col.)].The Liberated Page Edited by Herbert Spencer [San Francisco: Bedford Arts, 1987]. An anthology of the major typographic experiments of the 20th century, as recorded in Typographica magazine.TypographyA Typographic Workbook: A Primer to History, Techniques, and Artistry by Kate Clair. A good place to start for a basic grounding in typographic design.The Elements of Typographic Style by Robert Bringhurst. A highly acclaimed, although somewhat more advanced, standard work in the field.The Crystal Goblet; sixteen essays on typography by Beatrice Warde [Cleveland and New York: World Publishing Company, 1956]. From a major woman in the field of typography come some thought-provoking pieces, including the famous analogy that gave the collection its name. Mandatory reading for would-be typographers.The Case for Legibility by John Ryder [London: The Bodley Head, 1979] "Not a typographer's manual nor a 'do-it-yourself' guide to book design, it is a personal statement of great sincerity and conviction by a distinguished practitioner of the art." Ryder also wrote “Printing For Pleasure”, one of the touchstones of the avocational letterpress printing movement.Better Type by Betty Binns [New York: Watson-Guptill, 1989. 192 p]. A trade book from the early days of the desktop publishing revolution that shows by copious examples the subtle differences in relationships between typefaces, letters, and spaces. From the preface: "This book systematically trains designers to make these fine discriminations, with the aim of specifying text type that is not only readable, but also beautiful and expressive." Only released in this one edition, and not readily available, but a nice book nevertheless.Introduction to Typography by Oliver Simon [London: Faber & Faber, 1945]. Not a bad place to start. This edition is out of print, but there has been at least one reprint in recent years. Simon's introduction is designed for the layman, and discusses many of the basic principles and theories of designing with type.First Principles of Typography by Stanley Morrison [Cambridge: at the University Press, 1951]. An important book from the man who designed Times Roman for the London Times.Asymmetric typography by Jan Tschichold [(Translated by Ruari McLean) New York, Reinhold Pub. Corp. 1967. 94 p. illus. (part col.) facsims]. Jan Tschichold (1902-1974), a well-known typographer, caused many people to rethink 'conventional' theories of typography when this seminal work was published in the mid-60s. Whether or not you agree with his approach, this book is required reading and will widen your typographic horizons.An essay on typography by Eric Gill [1st U.S. ed. Boston: D.R. Godine, 1988]. A classic typographic manifesto on the art and craft of letterforms from the designer of Gill Sans and the famous typography of London Underground.Typography, A Manual of Design by Emil Ruder [Niederteufen, Switzerland: Arthur Niggli Ltd, 1977. 3rd Edition]. A fascinating, disciplined, and very Swiss analysis of typography and letterforms. Ruder's discussion and illustration of the importance of white space in letter forms and graphic designs is excellent background reading.Report on the typography of the Cambridge University Press by Bruce Rogers [Cambridge, Cambridgeshire: University Printer, 1950. viii, 32, (3) p. : ill.]. Bruce Rogers (1870-1957) is regarded by many as having been the greatest typographer and book designer of the twentieth century. After World War II he was commissioned by the Cambridge University Press to undertake a thorough review of all of the Press' publications and standards. The resulting Report had a major impact not only on the C.U.P., but also on the general typographic theory in both Britain and the U.S.Designing with type; a basic course in typography by James Craig and Susan E. Meyer [Fourth. ed. New York: Watson-Guptill Publications, 1999. 176 p]. A modern 'how-to' book, often used as the primary textbook in college design courses, that is available at many large bookstores and graphic arts dealers.Finer Points in the spacing & arrangement of Type by Geoffrey Dowding.Book DesignMethods of Book Design: The Practice of an Industrial Craft by Hugh Williamson. An excellent book, not only for the author's typographical observations, but also as a comprehensive survey of printing at the height of letterpress.The Design of Books by Adrian Wilson. A classic on the design, layout, and typography of traditional pages and books, written by a great letterpress printer in 1967.Bookmaking: Editing, Design and Production by Marshall Lee Originally written primarily about letterpress in 1965, this 500+ page work has recently been re-issued in a greatly updated third edition for the computer era.Printing Poetry: A workbook in typographic reification by Clifford Burke. A very informative work on this subject that also applies to other letterpress printing. Issued in an edition of only 1000.Type DesignersTwentieth Century Type Designers by Sebastian Carter [New York: Taplinger Publishing Company, 1987]. An excellent look at the people behind the type faces, with in-depth profiles of designers such as Goudy, Morrison, Zapf, etc.Typologia; studies in type design & type making, with comments on the invention of typography, the first types, legibility, and fine printing by Frederic W. Goudy (1865-1947). [Reissued 1977. Berkeley: University of California Press, xviii, 170 p.: ill.; 24 cm.]. Written by the most prolific type designer of the 20th century [creator of, among others, the eponymous Goudy Oldstyle], this reprint of the 1940 edition discusses the history, function, and meaning of type, and gives some very good insights into how a type designer works.Jan Tschichold: typographer by Ruari McLean [Boston: David R. Godine, 1975]. This puts Tschichold's career and writings in the context of developments in society around him. It is informative and thought-provoking on its own, and serves as useful background to his writings on the subject.Manuale Typographicum; 100 typographical arrangements with considerations about types, typography and the art of printing selected from past and present, printed in eighteen languages by Herman Zapf [Frankfurt, New York: Z-Presse, 1968]. Herman Zapf is known to most desktop typographers primarily for giving his name to the Zapf Dingbat font. He is, in addition, one of the most respected and creative typographers and type designers of the century, who created not only the Dingbat and Zapf Chancery fonts, but also Optima and many other faces. Manuale Typographicum is a breathtaking 'tour de force,' consisting of 100 broadsides about type design in a wide variety of faces and styles. Superb as a source of inspiration and example.Herman Zapf and His Design Philosophy by Herman Zapf, Introduction by Carl Zahn [New Haven: Yale University Press, 90 color plates]. While the Manuale shows the master at work, this volume is a discourse on Zapf's insights into type design. An excellent book.Edward Johnston by Priscilla Johnston [New York: Pentallic, 1976]. This biography of the twentieth century's most important calligrapher, written by his daughter, traces his career and influence. Unlike many printing books, this one is a delightful read.Of the Just Shaping of Letters by Albrecht Dürer [New York: Dover Publications, 1965. (reprint of the Grolier Club translation of 1917)]. Originally part of Dürer's theoretical treatise on applied geometry, here is the source for those famous capital letters set against a gridded background.Champ Fleury by Geoffrey Tory, translated into English and annotated by George B. Ives [New York: Dover Publications, 1967. (reprint of the Grolier Club translation of 1927)]. The other famous humanistic alphabet similar to the one discussed in the Dürer book, but this is the one with the letters shown against naked human bodies in addition to the grid system.Pioneers of modern typography by Herbert Spencer [Cambridge, Mass.: MIT Press, 1983. Rev. ed. 160 p. : ill.].Typeface Reference WorksAmerican Metal Typefaces of the Twentieth Century by Mac McGrew [New Castle, Delaware: Oak Knoll Books, 1994, 2nd rev, ed. 376 p. : ill]. The definitive work on the subject, and an essential reference for both graphic designers and current letterpress printers. Currently in print from the publisher.The Encyclopedia of Type Faces, 4th Edition by W. Pincus Jaspert, W. Turner Berry, and A. F. Johnson [Poole, Dorset: Blandford Press, 1983]. A standard, comprehensive reference in the field, this work is a detailed listing of over 1,000 faces, arranged by name, with full information on their history, designers, etc. Although even after several editions it has numerous uncorrected errors (dates, foundries, names, even occasionally an incorrect specimen shown) it is still a required reference work on the subject.A.T.A. Type Comparison Book by Frank Merriman [Advertising Typographers Association of America, 1965]. An indispensable handbook for identifying typefaces. Hundreds of faces are grouped together by design, making it easy to find the one you want. Still in print, possibly in a more recent edition.Graphics Master 7: Workbook of reference guides & Graphic Tools for the Design, Preparation & Production Print and Internet Publishing by Dean Phillip Lem [Los Angeles, Calif.: D. Lem Associates, 2000. 7th ed. 158 p. : ill. (some col.)]. Although it covers much more than just type design, and is fairly expensive, this is one of the most important and continually useful reference work that a desktop designer and/or publisher should have.Font & Function [Mountain View, California: Adobe Systems] was Adobe's biennial catalog of their latest font offerings. But this tabloid size, four-color publication was also quite a bit more. It included articles on typographic history, the background to many Adobe PostScript fonts, technical information and a graphic listing of over 1500 Adobe fonts. While it is no longer being published, back issues are available from a number of sources.The typEncyclopedia; a user's guide to better typography by Frank J Romano [New York: R.R. Bowker Co., 1984. xii, 188 p. : ill.].Type and typography; the designer's type book by Ben Rosen [New York: Van Nostrand Reinhold Co., 1976 Rev. ed. 406 p. : ill.].History of PrintingA Short History of the Printed Word by Warren Chappell [Boston: Nonpareil Books (David Godine), 1980]. A once-over-very-lightly in 240 pages of large type, hitting the highlights in the development of type, printing and bookmaking.Five Hundred Years of Printing by S. H. Steinberg [Baltimore: Penguin Books, 1974]. A 400-page small-print paperback which is still in print, this covers Gutenberg through the early 20th century. Steinberg's style is a little dry. Since his death, the book (starting with the third edition) has been edited by James Moran.A Dictionary of Book History by John Feather [New York: Oxford University Press, 1986, 278 pp] is a concise one-stop reference, in alphabetical order, to topics including bibliography and bibliographical terminology, the history of printing, the physical history of the book (including typography, binding, etc.) and book collecting. It has over 650 articles ranging from a few lines to several pages, and covers the ground pretty thoroughly. Although not a classic work (and, indeed, poorly designed itself as a book), it serves as a very handy reference to the history of books. An expensive purchase at the original price of $45, it is often available on remainder for about $10.The Making of Books by Seán Jennett [New York and Washington: Frederick A. Preager, 1967]. A good overview of the entire art and craft of the book, including a little history and a fairly detailed examination of every stage of the process. If you are interested in books in general, this is a good place to start. Out of print, but rather ubiquitous at second-hand and antiquarian dealers.The Book: The Story of Printing & Bookmaking by Douglas C. McMurtrie [New York: Oxford University Press, 1943]. Almost 700 pages of large type devoted to the history of the book, by one of the most prolific writers in the field. Easy to read, anecdotal, and illustrated. Although out of print, it is not particularly scarce and, if you can find it, probably the quickest way to get up to speed on printing history.Letterpress Printing InstructionIntroduction to Letterpress Printing by David S. Rose.: [New York: Five Roses Press, 2003, 32pp.] The complete 21st century Getting Started Guide to everything you need to know about acquiring a press, finding supplies, learning to print, and setting up your very own letterpress shop. (Note: this indispensable little reference gets first place on the list because it was written by [ahem] the author of this very bibliography. A fully hyperlinked electronic version with up to date sources can be downloaded from www.fiveroses.org/intro.htm)General Printing by Glen U. Cleeton and Charles W. Pitkin.: [Bloomington, Ill: McKnight & McKnight Publishing Company, 1941-1963, 195pp.] Probably the best all-around introductory book for traditional letterpress printing, this manual is profusely illustrated with detailed and useful photographs. It is the one most recommended on the Letpress list, and several members personally knew the authors. Copies of the book are readily available in both paperback and hardcover.The Practice of Printing by Ralph W. Polk (in later editions, together with Edwin W. Polk) [Peoria, Illinois: The Manual Arts Press, 1937-1945; later editions Charles A. Bennett & Co., 1952-1964, 300+ pp]. The most ubiquitous letterpress printing manual of the twentieth century. This is the standard, in print for over 40 years, from which many current letterpress printers first learned in school print shop classes, and is a good basic reference for the letterpress printer. Although out of print, it is readily available, in one or another of its many editions, from most book arts dealers and online sources. In later years, it was distributed by the Kelsey Co. as the advanced printing manual for their mass-market presses. By 1971 it was updated to de-emphasize handset type, and was re-issued as "The Practice of Printing: Letterpress & Offset". If you are primarily interested in letterpress printing, try to get one of the earlier editions.Platen Press Operation by George J. Mills [Pittsburgh, Carnegie Institute of Technology, 1953, 150 p. illus.] This manual is the first choice of letterpress cognoscenti who are printing on platen presses, and serves as the missing "owner’s manual" for traditional platen presses such as Chandler & Price, Gordon, Pearl and other floor-mounted job presses. It should be read in conjunction with one of the above books, which provide more thorough coverage of hand type-setting and composition. This invaluable book is still available, in a reprint of the 1959 edition, from NA Graphics.Printing Digital Type on the Hand-Operated Flatbed Cylinder Press by Gerald Lange (Second Edition). California: Bieler Press, 2001 This is one of the few letterpress manuals currently in print, and the only one specifically addressing both Vandercook proof presses (the gold standard for current fine letterpress printers) and photopolymer plates. This book is the authority on the technologies of "modern" limited edition letterpress printing. Subjects covered include digital type and computer practices; letterpress configuration; photopolymer plates, flat-bases, and processing equipment; photopolymer plate-making; plate registration and travel; impression; cylinder packing and makeready; presswork; ink and inking; press operation and maintenance, as well as an updated listing of manufacturers and distributors. Newly included with this edition are troubleshooting guides to problems encountered during the processing and printing of photopolymer plates.Printing on the Iron Handpress by Richard-Gabriel Rummonds is the most comprehensive book ever published on the subject, and is still in print from Oak Knoll Press. (Note that "handpress" here means something specific when it comes to letterpress printing, and doesn't refer to ordinary hand-operated presses such as a Kelsey or a Pilot.) Precise techniques for printing on the handpress are presented in lucid, step-by-step procedures that Rummonds perfected over a period of almost twenty-five years at his celebrated Plain Wrapper Press and Ex Ophidia. In tandem with more than 400 detailed diagrams by George Laws, Rummonds describes every procedure a printer needs to know from setting up a handpress studio to preparing books for the binder. The author also maintains a constantly updated web-site to accompany the book.Printing for Pleasure, A Practical Guide for Amateurs by John Ryder [published in multiple editions from 1955-1977, in England and the US, by publishers including Chicago: Henry Regnery Co., (1977) and London: The Bodley Head (1976) This is still in print from The Bodley Head in the UK or Oak Knoll Books in North America]. A lovely, classy, little (12 mo) book, both pleasing to look at and inspirational for the novice amateur printer. This introductory work gives a light overview of the hobby of letterpress printing on both sides of the Atlantic, covering how to choose a press, type, paper and ink, as well as planning, design and production. A good place to start if you are just considering taking up this avocation, and a nice place to come back to every now and then to remind you why you are still printing.A Composition Manual: PIA Tools of Industry Series by Ralph W. Polk, Harry L. Gage et al. [Printing Industries of America 1953, 4to, 311 pp., index, biblio., 433 pps] A really excellent tutorial and reference work, sponsored by the printing industry trade association as the definitive manual for apprentices. It is a thorough overview of the entire typesetting and proofing end of the business that took four years and several experts to write. Because it was published in 1953, it came out just at the inflection point between hot and cold type, and is a fascinating final masterwork from an industry that feels the winds of change approaching. In addition to very detailed and well-illustrated tutorials on hand-setting and proofing metal type, it includes surprisingly useful overviews and illustrations of all the other composition-related tools of the shop, including Elrod, Ludlow and Monotype casters. To quote from the Forward, "The industry recognized the need for a manual containing basic principles of good typography that are fundamental to the presentation of the printed word, irrespective of whether that word is composed by hand, by machine, by photo-typesetting or by some yet unnamed method of the future…"I.T.U. Lessons in Printing [Indianapolis: International Typographical Union, 1927-1972, Various paginations] Published in many editions across half a century, these ten volumes were created by the printing unions as the standardized training course for American printers. While not as elegantly written or produced as many of the other letterpress manuals, these thousands of pages cover just about everything the journeyman printer was supposed to know, eventually encompassing Unit One (Elements of [Letterpress] Composition) through Unit Ten (Photocomposition, Ruling and Pasteup). Along the way is detailed information on topics including Display Composition, Imposition and Lockup, Trade Unionism, Linotype Operation, Design, and even English ("because English is a 'reasoning' subject which may have caused the student difficulty in school."). The first volume, covering the history of printing through typesetting and a proofing, is probably the most useful one for the modern letterpress printer. The original edition of 1927, written by John H. Chambers, was replaced by a much better text in the 50's that was almost certainly ghost-written by Ralph W. Polk, who also wrote the even better manual on behalf of the employers, as well as his own manuals (see above).Printing For School And Shop by Frank S. Henry [New York: John Wiley & Sons 1917, B&W photos and drwgs 318pp] Subtitled "A Textbook for Printers' Apprentices, Continuation classes, and for General Use in Schools" and updated with another edition in 1944, this was the original vocational course textbook which was eventually supplanted for the most part by Polk. Nevertheless, it provides detailed technical instruction and illustrations and—particularly in the later edition—can still serve as a useful learning tool for today's printer.The Essentials of Printing by Frank S. Henry [New York: John Wiley & Sons 1924, B&W drwgs 187pp + index] Subtitled "A Text-book for Beginners" and half the length of the preceding book. "It develops that there is an insistent demand for a shorter text, one that shall cover only the absolute essentials of printing...this volume attempts to present to the novice, in sequence, the operations necessary to the production of a piece of printed matter." Useful and relatively short, but somewhat outdated (even for letterpress!)Printing as a Hobby. By J. Ben.Lieberman [New York: Sterling Publishing Co. & London: Oak Tree Press, 1963. 128 p. Index.] is the brash, bigger, and less restrained American counterpart to the quintessentially British book by Ryder. Lieberman was an enthusiastic amateur printer, and this book is an exuberant well-illustrated pitch for his hobby. The author was not a scholar (nor particularly an aesthete), but if you like unabashed 'boosterism,' you might find this book fun to read, despite its errors of both omission and commission (not unlike his later book, Type and Typefaces, described above.)Printing, A Practical Introduction to the Graphic Arts by Hartley E. Jackson [New York; McGraw-Hill, 1957, 8vo., 286 pages]. Organization and use of the type case, hand setting, use of the platen press, and basic binding, with short sections on linoleum blocks, silk screen and photography in this industrial arts text. Not as good as Polk, but more than acceptable as an apprentice course book.Graphic Arts by Frederick D. Kagy [Chicago: The Goodheart-Willcox Co., Inc., 1961, 8vo, 112 pps.] Another (and probably the last) of the high-school vocational textbooks designed for once-over-lightly printing classes included as part of a longer graphic arts program, this short book gives a simple but well-illustrated quickie introduction to hand type-setting and platen press printing in about twenty pages. Nowhere near as comprehensive as many of the others, but certainly better than learning through pure trial and error.Introduction to Printing, The Craft of Letterpress by Herbert Simon, [London: Faber and Faber, 1968]Getting Started in Hand Printing & Binding by Van Waterford, [TAB Books, Blue Ridge Summit, Pennsylvania, 1981]Other Book ArtsHand Bookbinding: A Manual of Instruction by Aldren A. Watson. A clear, thorough, inexpensive introduction to hand binding.The Papermaker's Companion: The Ultimate Guide to Making And Using Handmade Paper by Helen Hiebert. Extensive step by step instructions.How to Marbleize Paper: Step-By-Step Instructions for 12 Traditional Patterns by Gabriele Grunebaum. A slim, inexpensive, but useful paperback.Practical Typecasting by Theo Rehak. The ultimate and definitive book on the subject, by the dean of American typefounders.Miller's Collecting Books by Catherine Porter. A modern, illustrated guide to all aspects of book collecting.BibliographiesA Typological Tally compiled by Tony Appleton [Brighton, (T. Appleton, 28 Florence Rd., Brighton, Sussex BN1 6DJ), 1973. 94 p. ill.]. Thirteen hundred writings in English on printing history, typography, bookbinding, and papermaking, compiled by one of the world's top dealers in the field.A Bibliography of Printing with Notes and Illustrations by F. C. Bigmore and C. W. H. Wyman [London: Oak Knoll Books, 1978]. Universally known as "Bigmore and Wyman," this is to printing bibliographies what Updike is to books about printing types. Published in 1880 (editions since then have been reprints) B&W provides excellent commentaries on just about every book that had been written on the subject as of the year it was published.Book Dealers/Publishers Specializing in Typography and the Book ArtsOak Knoll Books, ABAA 310 Delaware St. New Castle, DE 19720 USA tel:302-328-7232fax:302-328-7274 www.oakknoll.com email: [email protected] Veatches Art of the Book P.O. Box 328 140 Crescent Street Northampton, MA 01061 tel: 1-413-584-1867 fax: 1-413-584-2751 www.veatches.com email: [email protected] Wakeman Books 2 Manor Way, Kidlington, Oxford OX5 2BD, UK tel: +44 (0)1865 378316 fax: +44 (0)1865 378934 www.fwbooks.com email: [email protected] Bookpress Ltd. 1304 Jamestown Road Williamsburg, Virginia 23185 USA tel:(757) 229-1260 fax:(757) 229-0498 email: [email protected] Hawley Books 915 S. Third St. Louisville, KY 40203 U.S.A. tel: 502-451-3021email: [email protected] Knuf Antiquarian Books P.O.Box 780, Oss NB, Netherlands, 5340 AT. tel: +31 412 626072. fax: +31 412 638755 email: [email protected] Book Shop 117 Water Street Exeter, NH, 03833 tel: 603-772-8443www.colophonbooks.com email: [email protected] Graphics Attn: Fritz Klinke P.O. Box 467 Silverton, Colorado 81433 tel: 970-387-0212fax: 970-387-0127 email: [email protected] R. Godine, Publisher 9 Hamilton Place Boston, MA 02108-4715 tel: (617) 451-9600fax: (617) 350-0250 www.godine.com email: [email protected] Press 1249 Eighth Street Berkeley, CA 94710 tel (800) 283-9444 tel (510) 548-5991www.peachpit.comDawson's Book Shop 535 North Larchmont Blvd. Los Angeles, CA, 90004 tel: (213) 469-2186Many thanks to Howard Gralla, Alvin Eisenman, Robert Fleck, Kathy Schinhofen, Chuck Rowe, Earl Allen, Susan Lesch, Kathleen Tinkel, Michael J. Boyle, John Horn, Chris Simonds, Fritz Klinke, Roberta Lavadour, David Norton, Tom Parson, David Goodrich and the many members of the Letpress Internet mailing list for their suggestions before and during the compilation of this bibliography.An earlier version of this bibliography was originally published by Aldus Corporation in conjunction with their release of the Fontographer type design application. That version was, in turn, adapted and expanded from an earlier annotated checklist by the same author prepared for members of the MAUG Forums on Compuserve.Copyright © 1988-2014 by David S. Rose [email protected] The current version of this bibliography is always available online athttp://www.fiveroses.org/bibliography.htm and hyper-linking to it is encouraged. For any other publication inquiries, please contact the author.Revision: August 20, 2003 / December 18, 2014

How does chemistry relate to cooking?

Before the invention of fire about 100,000 years ago, early man ate mostly nothing but fresh, live raw food. Once we discovered the amazing chemistry of cooking we populated the entire earth, including the many remote places where eating cooked food is necessary for survival. So, you see, the rules we have for eating in most cultures today are based on the “survival” paradigm. These rules doesn’t actually apply to a serious raw foodist since many things that may be a bit hard to digest when raw are actually not even necessary for people that choose a raw food lifestyle. The various digestive problems that some people associate with raw food are actually caused by a seriously “WEAKENED” digestive system caused by a lifetime of adaptation to cooked foods. Fortunately, it only takes a few months for you digestive system to adapt to a raw food lifestyle, or in a few cases maybe years for people with serious digestive issues.Some people consider nutrient absorption a problem with raw foods, since some cooked veggies only release nutrients after cooking. However, since raw food has much more nutrition and none of the toxins actually caused by cooking, you probably won’t need to eat such exceptions on a raw food diet. Over time, your body will get used to raw food and eventually those problems will just fall away. Your digestive system will learn how to accept more raw foods without any problems.The Chemistry of Cooking — a High School Experiment.The chemistry of cooking our food results in the biggest nutritional and health problems of all — the chemical changes to food molecules caused by heat that creates carcinogens, mutagens and free radicals that are the real causes for most of health problems in the modern world. Though the enzymes in raw foods are often mentioned by raw foodists, enzymes are not actually the biggest benefit of eatin g raw food. Your digestive system can makes those anyway. The big deal about raw food is the complete lack of all the toxins associated with the chemistry of cooking — which just so happen to cause most diseases!Cooking doesn’t just kill enzymes, however. The high heat associated with cooking actually creates brand new toxic substances, mostly from proteins reacting with carbohydrates. Some of these substances cause cancer or brain diseases and impair neurotransmitter function and metabolism.Some of these new substances are heterocyclic amines (HCA) that are directly or indirectly physically addictive. Due to the heat of cooking, these HCAs originate from the interaction between protein and carbohydrates and/or creatine (in red meat) or nitrate (in vegetables). For example:tryptophan + form- / acetaldehyde = 1-methyl-1,2,3,4-tetrahydro-beta-carboline (pro-mutagenic) (2)tryptophan + glycolaldehyde = 1-hydroxymethyl-tetrahydro-beta-carboline (3)tryptophan + sugars (by freezing) = 1,1′-ethyliden-ditryptofaan (very toxic)serotonine + formaldehyde = 6-hydroxy-tetrahydro-beta-carbolineserotonine + acetaldehyde = 6-hydroxy-1-methyl-tetrahydro-beta-carbolinetyramine + nitrite = 3-diazotyramine(4-(2-aminoethyl))-6-diazo-2,4-cyclohexadienone (carcin.)salt + nitrite + protein / sugar = 2-chloro-4-methylthiobutanoate (mutagenic)glutamate + sugars = 2-amino-6-methyldipyrido-(1,2-a:3′,2′-dimidazole (carcinogenic)glutamate + sugars = 2-aminodipyrido-(1,2-a:3′,2′-dimidazole (carcinogenic)When aldehydes react upon cyclic amino acids or -amines (like tryptophan, tryptamine, serotonine, phenylalanine, tyrosine, dopamine, tyramine, aniline), mostly beta-carbolines and isoquinolines originate. When creatinine (from meat) is involved, mostly imidazoquinolines and imidaziquinoxalines originate. (10) (Glutamate and tryptophan are amino acids, tyramine and serotonine are amines, and aldehydes are sugars) .In Which Foods?Almost all cooked or prepared foods contain:9H-pyrido(3,4-b)indole = beta-carboline = tryptophan / tryptamine + aldehydes (11)1-methyl-9H-pyrido(3,4-b)indole = 1-methyl-beta-carboline = tryptophan / tryptamine + aldehydes (11)These substances influence benzodiazepine receptors in the brain, and indirectly lots of other neurotransmitters. If these substances further react upon amines like aniline, they even become mutagenic. How much HCA originate depends on how much protein the food contains and on how much the food is heated.Because red meat contains both lots of protein and creatinine (creating creatine), prepared red meat contains the most HCA, especially when grilled (15). Besides prepared red meat, also prepared fish, soy and poultry contain lots of HCA. Flavor-enhancers and bouillon contain protein-concentrates and therefore contain lots of HCA too. (11) But also prepared foods containing less protein contain HCA, like prepared grains and -vegetables , and even foods like beer, soy sauce and canned orange juice. For example:Meat contains too much creatine:2-amino-1-methyl-6-(4-hydroxyfenyl)-imidazo-(4,5-b)pyridine (mutag.) = creatine + tyrosine + glucoseSoy contains globulins:2-amino-9H-pyrido(2,3-b)indole (mutagenic) (22) = soy-globulins + sugars2-amino-3-methyl-9H-pyrido(2,3-b)indole (mutagenic) (24) = soy-globulins + sugarsPrepared fish contains:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (mutagenic)(26) = tryptophan + acetaldehyde3-amino-1-methyl-5H-pyrido(4,3-b)indole (mutagenic)(26) = tryptophane + acetaldehydeCooked Vegetables contain nitrite:cancerous N-nitroso-compounds = amines + nitrite + sugarsspecific N-nitroso-compound ;4-(2-aminoethyl)-6-diazo-2,4-cyclohexadienone (cancerous) = tyramine + nitrite + sugarsCooked Cabbages contain thiocyanates ;toxic (29) tetrahydro-beta-carboline-derivates = isothiocyanate + tyramine / serotonine etc.Cooked vegetables contain also flavonoids:mutagenic glycosides = flavonods + heatCanned orange juice contains free amino acids, which easily combine with aldehydes to create heterocyclic amines.What Can HCA Do?1. Act like NeurotransmittersSome HCA, like beta-carbolines, can directly influence neurotransmitter-receptors, like benzodiazepine receptors. Simply because the body also composes beta-carbolines to function as neurotransmitters. HCA can also occupy receptors of other neurotransmitters, like serotonine- and dopamine receptors. Especially when they are composed of the same amines. For example;3-methoxycarbonyl-beta-carboline acts through different receptors (31) and increases secretion and decomposition of dopamine, like physical stress does. It enhances ‘irrational’ aggressive behaviour (33), and decreases social interaction.3-ethoxycarbonyl-beta-carboline, is hypnotic and anaesthetic (35), and inhibits investigative behaviour and social interaction. In dominant types it enhances aggressive behaviour, but inhibits sexual appetite. It increases epinephrine and cortisol-level blood pressure and heart rate, and increases secretion and decomposition of dopamine like physical stress does.3-Hydroxymethyl-beta-carboline ; though hypnotic, it negatively affects sleep.3-N-methylcarboxamide-beta-carboline enhances reckless- (44) and aggressive behaviour, and inhibits sexual appetite. (46) It generally inhibits, but locally stimulates norepinephrine secretion. It increases glutamate ACTH and Substance P-secretion, increases blood pressure and though anaesthetic, causes physical stress.3-Methylcarbonyl-6,7-dimethoxy-4-ethyl-beta-carboline blocks GABA receptors, increases GABA- and glycine-level, decreases glutamate- and aspartate-level, increases corticosterone-, epinephrine- and norepinephrine-secretion, decreases serotonine-secretion and increases norepinephrine-receptor-activity. It enhances the effect of cocaine, causes anxiety and suppresses immune system activity.3-Ethylcarbonyl-6-benzyloxy-4-methoxymethyl-beta-carboline is sedative, causes amnesia, and blocks beta-oestradiol-LH (lutinizing hormone) interaction.3-Ethylcarbonyl-5-benzyloxy-4-methoxymethyl-beta-carboline strongly stimulates appetite.3-Ethylcarbonyl-5-isopropyl-4-methyl-beta-carboline causes restlessness, sleeplessness and decreases social interaction.Besides ‘normal’ beta-carbolines, prepared foods also contain tetrahydro-beta-carbolines.Tetrahydro-beta-carboline stimulates craving for alcohol, increases heart rate and blood pressure, and like 5-methoxy-tetrahydro-beta-carboline and 5-hydroxy-tetrahydro-beta-carboline increases prolactine-level and affects serotonine receptors.6-methoxy-tetrahydro-beta-carboline increases norepinephrine- and ACTH- secretion, and decreases serotonine- and growth hormone secretion.2-Fenylpyrazolo(4,3-c)quinoline-3(5H)-one is sedative, increases corticosterone-level and decreases specific benzodiazepine-receptors in the brain.2. Cause CancerPart of the process causing cancer is mutagenic substances damaging cell-DNA. Some HCA in prepared food are mutagenic.DNA-damage increases linearly with intake of HCA. How cancerous HCA are is partly dependent on how much nitrogen they contain. Salt, protein and nitrite (from vegetables) can supply nitrogen to react upon HCA. And nitrosated HCA are even more cancerous. Some of the most widespread mutagenic HCA in prepared foods are:pyridoindole (amino-gamma-carboline)2-amino-9H-pyrido(2,3-b)indole (amino-alpha-carboline)2-amino-3-methyl-9H-pyrido(2,3-b)3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole3-amino-1-methyl-5H-pyrido(4,3-b)indole1-methyl-3-carbonyl-1,2,3,4-tetrahydro-beta-carboline4-aminobiphenyl4,4′-methylenedianiline3,2′-dimethyl-4-aminobiphenyl1,2-dimethylhydrazinephenyl-hydroxylamineO-acetyl-N-(5-phenyl-2-pyridyl)-hydroxylamine2-amino-3-methylimidazo(4,5-f)quinoline2-amino-3-methylimidazo(4,5-f)quinoxaline2-amino-3,4-dimethylimidazo(4,5-f)quinoline2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline2-amino-3,4,8-trimethylimidazo(4,5-b)pyridine2-amino-3,4,8-trimethylimidazo(4,5-f)quinoxaline2-amino-3,7,8-trimethylimidazo(4,5-f)-quinoxaline2-amino-n,n,n-trimethylimidazo-pyridine2-amino-n,n-dimethylimidazopyridine2-amino-4-hydroxymethyl-3,8-dimethylimidazo-(4,5-g)-quinoxaline2-amino-1,7,9-trimethylimidazo-(4,5-g)-quinoxaline2-amino-1-methyl-6-phenylimidazo-(4,5-b)-pyridine3. Cause Brain DiseasesSome HCA are directly toxic to the brain, like common quinolines, which enter the brain through the dopamine-transport system. Other common HCA (like pyridines and beta-carbolines only become toxic to the brain after they have been partly decomposed by different enzymes in the body. Originally , these enzymes have to, and do protect the brain against toxic substances, but part of the HCA are accidentally transformed into more toxic substances. Obviously nature didn’t count on ‘strange’ HCA from prepared food. Pyridines can only occupy dopamine-receptors, and therefore are toxic to these receptors only. Partly decomposed pyridines are more toxic than the originals, but the originals do decrease dopamine, norepinephrine and mostly serotonine-level. The destruction of receptors in the brain causes brain-diseases like Alzheimer’s, Parkinson’s and schizophrenia. Some toxic-to-the brain HCA are:3-N-butylcarbonyl-beta-carboline3-N-methylcarboxamide-beta-carboline2-methyl-1,2,3,4-tetrahydro-beta-carboline2-methyl-1,2,3,4-tetrahydro-isoquinolinequinolinatequisqualinatetetrahydroisoquinoline1-benzyl-tetrahydro-isoquinolineN-methyl-(R)-salsolinolN-methyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline6-methoxy-1,2,3,4-tetrahydro-isoquinoline2,4,5-trihydroxyphenylalanine6-hydroxy-dopamineN-methyl-4-fenyl-1,2,3,6-tetrahydropyridine1-methyl-4-fenyl-1,2,3,6-tetrahydropyridine1-methyl-4-fenyl-1,2,5,6-tetrahydropyridine4-fenyl-1,2,3,6-tetrahydropyridine4-fenylpyridine3-acetylpyridine1-methyl-4-phenyl-1,4-dihydropyridine1-methyl-4-cyclohexic-1,2,3,6-tetrahydropyridine1-methyl-4-(2′-methylfenyl)-1,2,3,6–tetrahydropyridine1-methyl-4-(2′-ethylfenyl)-1,2,3,6-tetrahydropyridine1-methyl-4-(3′-methoxyfenyl)-1,2,3,6-tetrahydropyridine1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridineThough toxic pyridines create oxidative radical and decrease antioxidant-level, the intake of antioxidants cannot prevent brain damage by toxic pyridines.AdditivesFood preparation exists primarily to make things edible that really are not so edible. Additives are primarily there to make fake food last longer, and to make you eat more. Taste enhancers for example are mostly concentrated protein, filled with lots of physically-addictive beta-carbolines that make you eat more. Glutamate (popular in the Chinese kitchen) indirectly influences the same (Benzodiazepine) receptors.Adapted from ”New Substances In Prepared Food” by Wai Genriiu. Copyright 2001 by Wai Genriiu, Adapted 2006-2017 by Robert Ross, RawFoodLife, LLC. Abstracts of most sources can be found at the National Library of Medicine.Selected References:Loscher, W. et al, Withdrawal precipation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil. Naunyn Schmiedebergs Arch. Pharmacol. 1992 / 345 (4) / 452-460.De Boer, S.F. et al, Common mechanisms underlying the proconflict effects of corticotropin, a benzodiazepine inverse agonist and electric foot shock. J. Pharmacol. Exp. Ther. 1992 / 262 (1) / 335-342.Little, H.J. et al, The benzodiazepines : anxiolytic and withdrawal effects. Neuropeptides 1991 / 19 / suppl. 11-14.Eisenberg, R.M. et al, Effects of beta-carboline-ethyl ester on plasma corticosterone -- a parallel with antagonist-precipated diazepam withdrawal. Life Sci. 1989 / 44 (20) / 1457-1466.(no author listed) Tetrahydro-beta-carbolines in foodstuffs, urine, and milk : physiological implications. Nutr. Rev. 1991 / 49 (12) / 367-368.Papavergou, E. et al, Tetrahydro-beta-carboline-carboxylic acids in smoked foods. Food Addit. Contam. 1992 / 9 (1) / 83-95.Rommelspacher, H. et al, Is there a correlation between the concentration of beta-carbolines and their pharmacolodynamic effects ? Prog. Clin. Biol. Res. 1982 / 90 / 41-55.Wakabayashi, K. et al, Recently identified nitrite-reactive compounds in food : occurrence and biological properties of the nitrosated products. IARC Sci. Publ. 1987 / 84 / 287-291.(8) Jolivette, L.J. et al, Thietanium ion formation from the food mutagen 2-chloro-4-(methylthio)butanoic acid. Chem. Res. Toxicol. 1998 / 11 (7) / 794-799.Sugimura, T. et al, Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods. Natl. Cancer Inst. Monogr. 1981 / 58 / 27-33.Overvik, E. et al, Influence of creatine, amino acids and water on the formation of the mutagenic heterocyclic amines found in cooked meat. Carcinogenesis 1989 / 10 (12) / 1293-1301. , Yoshida, D. et al, Formation of mutagens by heating foods and model systems. Environ. Health. Perspect. 1986 / 67 / 55-58.Solyakov, A. et al, Heterocyclic amines in process flavours, process flavour ingredients, bouillon concentrates and a pan residue. Food Chem. Toxicol. 1999 / 37 (1) / 1-11.Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233.Stavric, B. et al, Mutagenic heterocyclic aromatic amines (HAA's) in 'processed food flavour' samples. Food Chem. Toxicol. 1997 / 35 (2) / 185-197.Wakabayashi, K. et al, Human exposure to mutagenic / carcinogenic heterocyclic amines and comutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259.Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194.Gross, G.A. et al, Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grilled scrapings. Carcinogenesis 1993 / 14 (11) / 2313-2318.Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209.Rommelspacher, H. et al, beta-Carbolines and tetrahydroisoquinolines : detection and function in mammals. Planta. Med. 1991 / 57 (7) / 585-592. ,Pawlik, M. et al, Quantitative autoradiograph of (3H)norharman ((3H)beta-carboline) binding sites in the rat brain. J. Chem. Neuroanal. 1990 / 3 (1) / 19-24. , Rommelspacher, H. et al, Harman induces preference for ethanol in rats : is the effect specific for ethanol ? Parhmacol. Biochem. Behav. 1987 / 26 (4) / 749-755. ,Rommelspacher, H. et al, Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo. Eur. J. Pharmacol. 1981 / 70 (3) / 409-416.Totsuka, Y. et al, Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline. Carcinogenesis 1998 / 19 (11) / 1995-2000. , Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233.Vikse, R. et al, Heterocyclic amines in cooked meat. (in Norwegian) Tidsskr. Nor. Laegeforen. 1999 / 119 (1) / 45-49. , Sinha, R. et al, Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness. Food Chem. Toxicol. 1998 / 36 (4) / 289-297. ,Byrne ,C. et al, Predictors of heterocyclic amines intake in three prospective cohorts. Cancer Epidemiol. Biomarkers 1998 / 7 (6) / 523-529. , Kaplan, S. et al, Nutritional factors in the etiology of brain tumors : potential role of nitrosamines, fat, and cholesterol. Am. J. Epidemiol. 1997 / 146 (10) / 832-841. ,Ward, M.H. et al, Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference. Int. J. Cancer 1997 / 71 (1) / 14-19. ,La Vecchia, C. et al, Selected micronutrient intake and the risk of gastric cancer. Cancer Epidemiol. Biomarkers Prev. 1994 / 3 (5) / 393-398. ,Buiatti, E. et al, A case-control study of gastric cancer and diet in Italy : II. Association with nutrients. Int. J. Cancer 1990 / 45 (5) / 896-901. , Proliac, A. et al, Isolation and identification of two beta-carbolins in roasted chicory root. Helv. Chim. Acta 1976 / 59 (7) / 2503-2507. (in french)Salmon, C.P. et al, Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken. Food Chem. Toxicol. 1997 / 35 (5) / 433-441. , Shibata, A. et al, Dietary beta-carotene, sigarette smoking and lung cancer in men. Cancer Causes Control 1992 / 3 (3) / 207-214.Chiu, C.P. et al, Formation of heterocyclic amines in cooked chicken legs. J. Food Prot. 1998 / 61 (6) / 712-719. , Byrne, C. et al, Predictors of dietary heterocyclic amine intake in three prospective cohorts. Cancer Epidemiol. Biomarkers Prev. 1998 / 7 (6) / 523-529. ,Wakabayashi, K. et al, Human exposure to mutagenic / carcinogenic heterocyclic amines and co-mutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259. ,Salmon, C.P. et al, Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken. Food Chem Toxicol. 1997 / 35 (5) / 433-441. ,Skog, K. et al, Polar and non-polar heterocyclic amines in cooked fish and meat products and their corresponding pan residues. Food Chem. Toxicol. 1997 / 35 (6) / 555-565. ,Pfau, W. et al, Characterization of the major DNA adduct formed by the food mutagen 2-amino-3-methyl-9H-pyrido(2,3-b)indole (MeAalphaC) in primary rat hepatocytes. Carcinogenesis 1996 / 17 (12) / 2727-2732. ,Thiebaud, H.P. et al, Airborne mutagens produced by frying beef, pork and soy-based food. Food and Chemical Toxicology 1995 / 10 / 821-828. , Ohgaki, H. et al, Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates. Carcinogenesis. 1984 / 5 (6) / 815-819. ,Tomita, I. et al, Mutagenicity of various Japanese foodstuffs treated with nitrite. II. Directly acting mutagens produced from N-containing compounds in foodstuffs. IARC Sci. Publ. 1984 / 57 / 33-41.Knize, M.G. et al, Characterization of mutagenic activity in cooked-grain-food products. Food Chem. Toxicol. 1994 / 32 (1) / 15-21.Ozawa, Y. et al, Occurence of stereoisomers of 1-(2'-pyrrolidinethione-3'-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in fermented radish roots and their different mutagenic properties. Biosci. Biotechnol. Biochem. 1999 / 63 (1) / 216-219. ,Sen, N.P. et al, Analytical methods for the determination and mass spectometric confirmation of 1-methyl-2-nitroso-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid and 2-nitroso-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in foods. Food. Addit. Contam. 1991 / 8 (3) / 275-289. ,Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209.Herraiz, T. et al, Presence of tetrahydro-beta-carboline-3-carboxylic acids in foods by gas chromatography-mass spectometry as their N-methoxycarbonylmethyl ester derivates. J. Chromatogr. A. 1997 / 765 (2) / 265-277.Skog, K.I. et al, Carcinogenic heterocyclic amines in model systems and cooked foods : a revieuw on formation, occurence and intake. Food Chem. Toxicol. 1998 / 36 (9-10) / 879-896.See more references in the articles on my website at:RawFoodLife.com - It's not Just Good for You, its Good Science!)

View Our Customer Reviews

You wouldn't really think there'd be much of a market for this product, but I'm it. Specifically because I invoice clients through PayPal, which is very particular about the types of files it will accept to attach to those invoices. The CocoDoc software makes communication with clients easier. Whether I've got a spreadsheet, a JPG or pretty much any other type of file, I can send it along. Interestingly, you can do it in reverse, too! Convert a PDF to Office formats, for instance. Furthermore, you can rotate, number, merge and more. So, say you've scanned something using PDF scanner. You can edit the resulting file using this software. Very handy!

Justin Miller