Pdx Application: Fill & Download for Free

There is an international electronic exchange for patent documents called PDX, where you can send certified copies of your filings to other jurisdictions.Typically, you would use this to supply a certified copy of your filing to WIPO when you file a PCT application, for example. You would provide the serial number, filing date, and confirmation number, and WIPO would automatically retrieve the document from the USPTO.

I've admired Portland from afar for over a decade, but made the move from the Bay Area to Portland earlier this year.Most folks seems to be focusing on the differences between SF and PDX (which I mostly agree with), so I'll add more details about how my actual move went:I left my full time job in SF a month ahead of the move to prepare. I was able to sustain freelance graphic design work during the transition. My husband also has a work from home job that enabled us to move whenever we were ready.We put away a small amount of money each month for about a year to count towards the move. I think we ended up with just under $9k, which was more than sufficient.We sold most of our large furniture and many possessions so we could fit our belongings in a small 7 foot portable storage unit. PODS is pretty great because they will store it in a facility near your destination for up to a month (I'm not sure if other portable storage unit companies do this).We drove up without many rest stops, as we had a pet with us. It took about 10 hours. I'd recommend driving up during a dry season so you don't have to deal with inclement weather, especially up in the pass.We reserved an apartment through Airbnb, and subsequently a local friend's place to stay in while we looked for a house. It was really nice to take our time finding a house, because we could get to know the neighborhoods a bit better before settling on where we wanted to live.The rental market is competitive, but not nearly as much as SF. It still doesn't hurt to have your applications (and credit reports if needed) in hand while you attend open houses. This is most certainly how we secured our place.More thoughts on adjustment from SF to PDX:Everyone probably already knows this, but the cost of living is so much better in PDX than in SF. We moved from a small 1-BR apartment in the SF suburbs to a 2-BR house in a desirable PDX neighborhood for less rent. Food is more accessible and cheaper, and the lack of sales tax is a bonus.Separating your trash. I know SF does the recycling and composting thing, but there are some subtle rules from Portland Waste Management that I question all the time. The "Sanitation Twins" sketch comes to mind:I know people say this all the time, but I'll reiterate that you need to be well-prepared for the change in climate. SF folks are used to carrying around a light coat and sweater all the time, and dressing in layers. Once I was in PDX and transitioning to winter, I was completely unprepared with actual warm clothing. Yes, layers are helpful, but they need to be the right types! Wool and silk base layers have been my friend. Heck, wool clothing in general is great.Speaking of clothes, and agreeing with what other folks have already said here, I don't feel a pressure to be stylish, and I really like that about PDX. Dressing for comfort is the norm.Shoes: anything to keep your feet dry. I learned the hard way that my collection of ballet flats that I wore all the time in SF just did not cut it in the fall and winter weather here. I usually see folks wearing boots or athletic shoes. Add wool socks as a bonus.Hats: Build your collection, for both warmth as well as protection from the rain ('cause no one carries an umbrella here).Okay, more on the weather: the inconsistency of weather in SF drives me nuts (it can change wildly from day to day, or even AM to PM). I love that Portland actually has seasons.I had to get used to not being close to the ocean. Still, it's only a little over an hour away. And now we're close to the gorge, waterfalls, mountains, etc. It's so much more scenic here, in general.People kept warning me that PDX is not as diverse as SF, but I honestly don't see a big difference... I think it's the density that is different. As an Asian-American, I haven't felt like I am a fish out of water, I always have felt comfortable here. Maybe that has to do with the types of personalities that live here, everyone I've encountered is comfortable and friendly with each other, regardless of race.

All deals like this are bets, of course, and it will be years before we know whether this bet pays off. But there are bad bets and good bets. A bad bet is one whose failure is foreseeable, like Merck’s acquisition of SiRNA, because it assumes an answer to a fundamental problem will somehow be found (targeting and delivery of RNA, in the Merck/SiRNA case).This bet looks a good deal better. The Stemcentrx value proposition, as I understand it, is the following:Traditional lab models of cancer (cell culture and mouse xenografts) are deeply flawed. As a result, drug candidates that work well in preclinical testing often are complete failures in the clinic. This observation is indisputable - we know how to cure cancer in mice, but not in humans.Patient-derived xenografts - the implantation of tumor tissue from patients directly into mice - provides a much better model of cancer, one which captures the heterogeneity of actual tumors.Within these heterogenous tumors, there exists a subset of “tumor stem cells”. Although not really stem cells, this subset of cells acts as a seed capable of regenerating tumors. Treatments that kill 99% of the tumor, but leave the TSCs behind will provide only a temporary remission, ultimately leading to clinical failure.Patient-derived xenografts, unlike traditional cell-culture xenografts, contain TSCs. They thus provide superior models for target identification, and for testing the efficacy of treatments. These advantages should translate into fewer clinical failures of drug candidates, and greater efficacy - perhaps even cures of previously refractory cancers.So far, so good. Of course, we’ve been here before. Twenty years ago, many scientists were convinced that anti-angiogenesis therapy was going to cure cancer. That didn’t happen. Cancer has a long history of springing nasty surprises that defeat the most promising advances.But Stemcentrx’s first candidate, an antibody-toxin conjugate to treat small cell lung carcinomas, is already in clinical trials. SCLC’s are common enough and deadly enough that a truly effective treatment for them would probably justify the deal valuation on its own. Obviously AbbVie was sufficiently impressed by the current clinical data to write the check.It’s not clear how much value Stemcentrx adds as a platform technology. Although the company has plenty of patents and patent applications, it does not appear that PDX models per se are patentable - plenty of other organizations use them. So even if PDX models really do lead to better cancer therapeutics, Stemcentrx will not be able to capture all of this value.$5B (the actual payout before milestones) is a lot. But it is not an obviously stupid bet. The potential downside seems to be that new cancer drugs are produced, but that they are not breakthrough revolutionary products - that cancer will outwit us again, and the new drugs will be only incremental improvements over competitors. The upside is that some truly effective treatments for currently untreatable cancers will emerge, ones that justify their six-figure costs. That upside makes the deal seem like a pretty reasonable bet.