What Happens During A Chemical Reaction And How Can It Be Bb: Fill & Download for Free

Start with the fact that matter and energy are related in that the total Energy in a system (I use capital E here to represent the total energy including mass) of something is the total energy of the mass (E=MC^2, where M is the inertial mass which, I believe, includes the energy bonding its constituent parts together, plus any energy associated with it (a moving object has kinetic energy, as well as potential energy if, e.g. it is in a gravitational field. Heat (its temperature) also contributes to its energy as would any electric charge, magnetism, etc. The “M” portion in E=MC^2 can be converted into various forms of energy (heat, light, momentum, etc.) in e.g. a nuclear reaction. And chemical reactions can convert some of that mass by breaking/making bonds e.g. if you burn something such as a log, the mass of the ashes and gasses used (e.g. oxygen)/released (CO2, etc.) from burning a log don’t add up to the mass of the log. You have to account for the heat and light that was released to account for everything. Where the statement “energy can never be created or destroyed” comes from is that in a closed system (the universe can be seen as a closed system) the total energy (mass + all forms of energy) cannot be created or destroyed. It can be converted into different forms of energy and mass (molecules) can be converted into different forms of mass (different molecules) and/or into energy, but the total Energy within the closed system remains the same. If you were to burn the log in a closed system and accounted for everything, log, heat, ashes, light, oxygen, CO2, etc.) then you will find the total Energy (capital E) remains the same within that closed system). Viewing the universe as a closed system, the total Energy remains the same over time, at least from the moments after the Big Bang. Since we know nothing about the moments before or the moment of the Big Bang itself, assuming it really happened (theory only takes us to the moments after it), we can’t really comment with any confidence what happened before or at the moment of the BB. Again, assuming it really happened. That is still theory based on our knowledge of science and observation as we extrapolate back in time.One theory is that if began as a quantum fluctuation and the total Energy of the universe is zero or very nearly so, if you treat gravity as negative energy exactly or very nearly balancing the total energy of everything else that exists. Another is it started as a singularity, perhaps formed by the collapse of some prior universe, that included all of the Energy contained within the universe. Or… (fill in one of any of a number of theories). But the equations (QFT/Quantum Mechanics and General Relativity, don’t really provide an answer. They simply give us hints.One answer noted that you can create a particle and anti-particle from “nothing” as long as certain parameters are conserved (charge, etc.) but it takes energy equal to the total Energy of the particle/anti-particle pair to create them so it is conserved and converted back to exactly the same amount of Energy when they annihilate each other.

According to Give blood they have stated that you can give blood if you:This is NOT something you want to ignore (especially when it can be treated). If you’re struggling with blood pressure take a look at this: Blood Pressure Exercises VSL cbIf you have a few minutes this video is worth watching.Prefer to read?hey everyone it’s Mike Munsell with high intensity health radio where we cover the best of fitness nutrition and functional medicine so glad that you joined us because today we’re going to talk about heart disease from a totally new perspective really from the angle of physio mechanics and blood viscosity and the stickiness of blood that’s something that a lot of individuals in preventive or integrative medicine are not really talking about and also in the traditional realm those individuals are not talking about that either so we dive into that with my good friend an integrative medicine expert dr. Ralph Holsworth and he knows his firsthand he’s actually an emergency room physician that’s what he does so on this day job so to speak and at night on weekends he’s an avid researcher he’s well published he’s done a lot of research in the field of enzymes proteolytic enzymes we talked about stirrup pep days and nano kinase and we also talked about blood viscosity that’s kind of his new big interest level right now he actually worked with Jonathan Ryan to develop a blood viscosity test that you’ll learn more about why am I making such a big deal by blood viscosity well it’s actually linked with an 88% reduction in heart disease risk if you can lower your blood viscosity so we talked about all these different studies he’s looked at three hundred some odd studies and all and all the different risk factors blood viscosity keeps coming up is even more predictive or more indicative of high cardiovascular risk compared to smoking we know smoking is one of these really problematic risk factors so you’re going to learn a lot about this and therapeutic applications that you can implement in your life the use of enzymes donating blood exercise proper sleep and burning that belly fat to reduce plasminogen activator inhibitor one or pie one that we talked about and I know it’s a mouthful but you’re going to learn more about that so I really hope you enjoyed it if you do please subscribe to the channel you can also listen to this over in i. Tunes or on stitcher high intensity health radio just type that in and you’ll pull it up and you can subscribe there too hope you enjoy and have a great one between diastole and systole or the relaxed and squeezing stages of the heart blood thickens four to six fold if you can imagine the blood sort of starting and stopping and starting and stopping and this sets up the flow dynamics and it’s the really the hemo rheology or the physics of the blood that contributes to a thorough Genesis so once blood becomes thick it actually causes a sterile inflammation on the endothelium then you get what we call endothelial dysfunction which you mentioned very eloquently again in your book welcome to high intensity health radio the best of fitness nutrition and functional medicine and now here’s your host Mike muscle all right welcome back to the whoa and I’m very excited for today’s guest we have with us dr. Ralph Holsworth he’s a proteolytic enzyme expert and also an expert in blood viscosity which is going to be the topic today so get ready for that too dr.Holsworth is a doctor of Osteopathic Medicine and he’s board certified in family medicine as well he has served as the environmental scientific consultant for the EPA the Environmental Protection Agency an honorary professor at the university of colorado department of biology and multiple other publications and so for that dr. ralph will get into you but dr: ralph welcome thank you really appreciate this opportunity yeah I’m very excited to chat with you we’ve known each other I think since oh seven and you know we’ve both lived in Colorado and then you were in Seattle and then now you’re back in Colorado though let’s talk about your background your work with enzymes and then how you’ve transitioned to be an expert in blood viscosity and you bet I went to medical school in during medical school I actually had a friend of mine give me a book and it’s called enzymes the fountain of life well David Williams was one of the authors and so you know one of my bad habits is when I read a book or something that excites me which that book did profoundly I will call up the author and try to get more information and so that led into an academic relationship with dr. Williams who is a MD Ph. D he was an oncologist one of the top doctors involved with Cancer Treatment Centers of America and then Blum behold he introduced me to dr. Carl Ron Berger Ph. D and of course you’ve heard of MU Coast pharmaceutical the German company which actually the woman’s I’m so that’s really how I got into enzymes now reading a book and digging a little bit deeper and trying to meet the people in the know and I credit dr. Carl Ron’s burger for giving me a tremendous amount of the direction in looking at the clinical applications in their therapeutic attributes of it and oh probably about three or four months prior to his death he had mentioned thatl kinase and he’d actually which was entered was sort of out of character German researcher he was very keen on sticking on task and just you know did tremendous amounts of research willful a bit lobe enzyme so for him to bring natto kinase up I thought while there’s something there so I credit him also for allowing me to go over to Japan and make and meet doctor who yogi Sumi I’ve met with him twice and that continued my pathway especially after his departure fascinating that I knew that we would get along and be good friends that when we first spoke on the phone and this was I think a Friday afternoon and you you’re doing hospital work at a time and then you said yeah well my weekends are really devoted to studying and research and at the time that’s all I was doing as well so as you’re also working in the hospital setting what is X are you doing there well I work in a very small rural setting and I cover the emergency room 24/7 for about 12 days and that allows me to just stay up to date with a lot of therapeutics and allows me to basically get the research from you know we always say from the bench top to the bedside and so that’s I think really integral that I’m grounded there I see the inadequacies and and sometimes just where we can you know do a better job and so that’s what I get to do and I really enjoy it in a very small rural community in Colorado that’s great now do you get to use any of these enzymes that you studied clinically at the hospital or is that more in your outpatient if you do see patients on the side how does that work well I don’t use them in the emergency room per se but I did have quite a few clinical patients so I actually do three things and it sounds little you know it’s not multitask but I do cover the ER I do have clinic patients and I also admit people to the hospital so and so during that time yes absolutely I’ve been able to use enzymes and then some integrative therapy IV blue Payan phosphatidylcholine you know the buter rates a number of integrated vitamins ascorbic acid so yeah they’re very I’ll call tolerance of my food but it’s all supportive and I just have more tools in my tool bag and so my patients really appreciate that and that’s who I’m always striving to meet their expectations to you know help them along their health journey yeah that’s fascinating so let’s dive into blue analytic enzymes and what are they and how do they work a lot of people think if you take an enzyme it’s gonna be broken down by hydrochloric acid in the GI tract but we know that not to be true so let’s walk us through the science here and talk about some of the most potent ones that people can take oh absolutely so there’s a number of different broad categories they actually have different numbers it’s sort of like a zip code and each number tells exactly what it cleaves or what it breaks off from a protein so for the most part all the therapeutic enzymes that we use are from a large classification called class three which are called hydro lays and what that means that anything first I should preface anything that ends in ASE suffix usually biochemically suggests that it is an enzyme there are always exceptions but the modern nomenclature dictates to that so we have hydrolyze and what that means simply is that they’re going to break a protein open and put a water molecule so I tell everyone think of proto like enzymes as having a water X they’re going to break the protein down but putting in a water molecule now of course different enzymes do that in different manners in ways so there’s you know we break those down into further classifications from that so but the majority of them were what we call endo peptidase meaning in de meaning they cleave inside bonds not EXO in other words the ones on the outside of a long protein chain okay so these musically cleave the water and that’s how are able to break up larger molecules in a smaller component their component parts yeah they cleave the proteins but they do it by putting in a water molecule and and I should say that that is a biochemical catalyst in other words that there are chemical reactions in the body as you know with your background that would never ever happen unless there was an enzyme you know taking the you know product a to product B substrate that’s great those trypsin chymotrypsin their syrup peptidase and then nano kinase I’d like to talk about that at the end because they’ll give us a nice segue into blood viscosity but let’s talk about some of the new enzymes that are out there and maybe potentially better than that so anything on just the basics of trypsin chymotrypsin engine and then also of syrup peptidase that you want to speak to oh absolutely and you mentioned earlier at which I thought was very adroit was that you know the common perception is that these enzymes are broken down by hydrochloric acid well that’s there are some that had sensitivities to stomach ph’s but in the large part these enzymes are shuttled into the immune system through the Gulf yeah which is God associated lymphoid tissue and they bind immediately to the immune system so very similar to a infant breastfeeding you know it’s getting its Ig. A secretion to come in you know it’s getting that from the breast milk so again very similar that we do know and it’s been very well documented that we do have endogenous activities from enzymes that we ingest in our systems so and they go right into the immune system so in contrast with pharmaceutical drugs which is you know portal they go through the p450 liver well you know phase 1 phase 2 breakdown and then it’s really the byproducts or metabolites that cause the effects of pharmaceutical drugs enzymes pretty much go right into the immune system and I think that’s why we see generally you know I personally have to witnessed any adverse drug reactions if you will to in these lines because of that ability to you know identify if you will with the immune system well so we’re bypassing the whole liver you know detoxification pathways and going is it the doctor Holdsworth going through the lymphatic vessels and right into the immune system that way exactly the microcosm and there’s a particular I call it the enzyme bus if you will those are called alpha 2 macroglobulin and I tripped today’s so there’s various different ones for it but for the most part alpha 2 macroglobulin it’s basically a Venus flytrap mechanism it’s a very large protein it actually has a little bait a little trigger your protease enzymes will actually trigger that and then you’ll see that that activates it it clamped down on it like the vena you know ie the fly being the enzyme and the Venus flytrap being this alpha 2 macroglobulin and then that shuttles it to where it needs to be in the body and you’ll hear some late people mention the intelligence of enzymes then I think academically I’m ok with that because there is an intelligence because it is basically going right into the immune system and assisting whatever the immune systems major task is so I tell a lot of people if you want to go to a flyer you know chances are if you jump on a fire truck with bells and sirens going you’re going to end up in a fire same thing Keva enzymes a couple onto this alpha 2 macroglobulin fire truck they’re going to go to your tinnitus of inflammatory wherever that is in the body and when they get there we’re talking about adding water molecules to break up proteins what exactly are these proteins are these you know inflammatory proteins created by the immune system and what are we how does it reduce inflammation or improve mobility or you know any of the other you know benefits that’s an excellent question and it’s a little bit calm but the short story is that it revs up the immune so technically enzymes are called biological response modulators so that’s a certain category that it may neither is a specific immune stimulator nor suppress it it just does the right thing when it needs to be so absolutely the other thing when you bind this the altitude macro problem it goes from a slow stage to a fast stage so what that means is is taking the garbage out instead of doing it once a week it’s doing it once every hour or ever I mean my analogy is you know and that’s a general analogy but what that’s doing is taking out these immune complexes this crosstalk that we see in autoimmune diseases and cancer in cardiac diseases so you’re absolutely correct it has a significant direct and indirect you know effect on the immune system but overall it’s very therapeutic for the body sure and what about them you know post injury people roll their ankle sprain their wrist that’s something like that where there’s a lot of localized inflammation what do you generally recommend in terms of dosing empty stomach full stomach how many times a day what would be your general protocol there well my general protocol is an ER doc I think getting away from instead completely you know I do have taken some training in pro law therapy and that’s really even focus my attention that I can’t delay the inflammatory process you know it’s been with us for thousands and thousands of years it’s really why we’re here today it’s it’s a success story as far as you know as humans are concerned in any mammal but to the short story is that when you take enzymes that’s going to push you through the inflammatory and actually cut your healing time if you will about 50% that was well documented in at least 2030 things that I know uh but to answer your other question bromelain is what I usually recommend and you know you can take some of these enzymes you know I think a lot of them you know with one benzine they had recommended that that be on an empty stomach I’d eat one hour before two hours after that’s important that it has more to do specifically with some of the enzymes in that formulation that are not tolerant to the p. H and that it’s different for different enzymes so you can’t always recommend you know taking them on an empty stomach specifically with nattokinase I know there’s still some confusion in you know amongst some of the health professionals regarding that so sure no what about syrup peptidase I know that’s one that has a lot of research for maybe biofilm and things of that sort any updates from your perspectives I find it amazing enzyme you know because it’s you know specifically it’s a mucolytic I mean that’s what I’ve used it with chronic sinusitis I’ve used it with any better with COPD reactive airway disease is you know bronchiectasis interesting enough and Japan you know they really look at enzymes as being a pharmaceutical drug and there’s actually one enzyme it’s a type of sera peptidase that they actually have combined with an antibiotic and it’s specific uses for sinusitis it increases the bioavailability again if I can refer back to my previous explanation of how enzymes are picked up by the immune system the altitude microbiome etc that makes you know a little dab will do it in other words it enhances the availability and whatever you like that previous antibiotic it helps penetrate the sinuses which can be sort of an immune privileged area in a lot of humans or why did you mention the biofilms you know that’s a classic area for biofilms as well as the biliary tree you know so excellent point when it’s available now is the ability to instead of use the enteric coating which I know entire coating there’s a lot of heat involved from a manufacturing standpoint the ability to use acid resistant vegetable capsules so mentioned that the caustic p. H of the stomach may be certain enzymes are intolerant to that so one way to bypass that is the acid resistant veggie caps that disperse in a small intestine have you looked at that research it on it’s been some time I’ve looked at it but yes I have a lot of things that specifically with nano kinase I’ve looked at a lot of you know pharmacokinetics as far as you know delivery and the reason is you know I think there should be two types of natto kinase and I apologize I’m jumping ahead but I do know there’s a preventive modality for natto kinase and others also a therapeutic in other words I’ll call it a nine one one type of use of metal kinase because you know as a doctor I’ve used it in the emergency room that’s investin settings very rural settings where I didn’t have recombinant TPA or what we call clot Buster’s so great well let’s segue right into natto kinase and talk more about that so two different forms for two different applications she’s going to get into those a little more depth yeah I think it’s just the time of onset we know once you put natto kinase in your mouth it’s sort of the activity in your bloodstream in other words maximum clot busting capacity if you will sort of Peaks around six hours so someone in atrial fibrillation someone at a high risk or susceptible for a CVA or stroke heart attack blood clot etc then I’m recommending they dose qid four times a day particularly at bedtime because you know there’s a thing called pi 1 its Pai 1 which is plasminogen activations inhibitor when that sort of increases that’s when we see people presenting with their heart attacks and strokes and you actually reference I believe you know what we call Black Monday in other words there’s a statistical proportion of males who have acute MI heart attacks on Monday and again this is a lot of that is secondary to max inflammation sort of the parasympathetics and the PI one being at its elevated level in the human so wow that’s great so the nano kindness is it affecting pi 1 or is it just helping with the the viscosity d what is it doing exactly oh that’s a great question it’s doing both and that’s why I’m so excited about it because not only is it it’s got a little pac man you know about 10% of the modus operandi is you know eating chewing up it is very specific let me back up one second here it’s very specific for cross linked vibrant I mean if it was a pacman that’s all it would eat would be cross linked vibrant so that’s very good it’s not in it’s not in there eating chewing up your albumin or chewing up any other type of proteins that your body needs so let me qualify that from the beginning secondarily 10% is actually chewing on the clot but the majority of the action just like you said has to do with that it revs up your pot your ability and it revs up to your kinase as Webb’s up your plasmid all those are or enzymes that your body makes so it was a synergy and it up regulates all that so it’s really nurturing Nature’s Way I ensure I pledge rise that from someone but the short story is you know it really does put your body in a super defensive mode to break up any clot that may form and you know I’m just seeing some remarkable cases that you know as a physician overseeing it and wide variety of patients great so I haven’t looked at blood discuss in in a long time but fibrin would be bad plasminogen would be good it’s as leak exactly so exact plasminogen so the activator inhibitor pi is inhibiting plasminogen activation so that’s why it’s bad so in turn no sleep app you have belly fat inflammation diabetes and so on are all linked with PI being activated by one which is going to make one more viscous and increased risk for various cerebral vascular cardiovascular diseases is that where we’re going that’s absolutely correct and that’s really why when I read your book the belly fat effect I got so excited because I was like oh okay here’s how this comes home you know this really for me at least academically sort of you know pulled it all together for me like you said you know these are things we general protocols and practices we know to be generally accepted as a good thing but now what you presented and I was impressed with company preferences you had with that book was you know here it is here’s the science here’s the research so you know that that’s where I have to hang some well thanks so much that took a while it took many weekends and yeah I’m glad that you found it helpful and hopefully other people will find it helpful as well so yeah we know dr.Hall’s worth car vascular diseases continues to be the number one killer worldwide and we’ve been talking about thick blood and so forth let’s define blood viscosity and what that is and why that’s so problematic for our vessels and arterial system absolutely another book I read in another author and I have to give him credit was dr. Kim Kinsey cardiologist he did a lot of research with a dr. Jung Cho I continue to research with dr. Jung Cho the medical school I was like there was seem to be just a litany of different things that created cardiovascular disease well and again the common denominator that pulled this all together was you know blood viscosity there’s 300 independent cardiac risk factors if you look at the common denominator in each and every time it is old blood viscosity so it’s actually more sensitive than whether a patient smokes or doesn’t smoke and I’ll be glad to share all those references and research so the other thing that gave me not to digress too much was you know Iran nuclear reactors in the Navy so I learned a little bit about fluid mechanics and so once I met with dr.Kinsey a cardiologist and then dr. Jung Cho a physicist both leading experts in blood viscosity then I was able to really apply a lot of the retrofit if you will some of my previous knowledge from the Navy and applied that you know basically you know run a tan reactor and preventing corrosion and apply that to the human circulatory system and their nurse differences number one blood is a non newtonian fluid meaning that when you put sheer into it it changes so probably the one that a lot of people niching take is ketchup and ketchup you turn the bottle upside down it doesn’t flow very well but give it a little jerk and it starts to flow well that’s very similar to the flowing I mean that’s a non newtonian fluid once you impart shear or energy into it and it starts to flow so between diastole and systole or the relaxed and squeezing stages of the heart blood thickens four to six fold if you can imagine the blood sort of starting and stopping and starting and stopping and this sets up the flow dynamics and it’s really the hemo rheology or the physics of the blood that contributes to a thorough genesis that’s not to say I don’t completely agree with everything that Faust and the vulnerable plaque and the traditional biochemical models say of how plaque begins I’m just backing the starting line if you will into the blood stream so once blood becomes thick it actually causes a sterile inflammation on the endothelium and you get what we call an ethereal dysfunction which you mentioned very eloquently again in your book so you know it all ties in again so I’m also looking at the physics and what’s very exciting you know to bring this home what’s exciting about nano kinase is that my clinical research showed that it decreased blood viscosity where up to 18 to 20 percent so a huge benefit as far as not filling the blood technically you know but allowing it to flow but I mean you know the bodies that able clop just as efficiently when it’s on that’ll kinase it’s just that the physical thickness of it is you know 18 20 percent decreased this is really interesting Ralph and until you bring up a huge you know curveball on the whole lipid hypothesis of cardiovascular disease because like you said we’ve been focused so much on the biochemical the cholesterol the triglycerides the lipids even hypertension but now we we dig deeper and can you know quantify this and I would love for you to talk more about that more about this blood viscosity so basically you know during contraction we have a you know the sheer mechanics change the whole hemodynamics and that creates it just a localized inflammation and in the vascular system is that what I’m hearing absolutely and it occurs in very particular areas and it’s a little bit more complicated because remember I said blood has different viscosity so when it’s getting ejected out of the left ventricle into the descending aorta etc then it that’s what we call high shear so it’s moving very quickly it has a lot of energy so that’s when we see a lot of arterial sclerosis in other words the stretching of the vessels I guess the easiest way to say this is that when you you know it has a lot to do with the thinness of the blood and then the other side of it the low shear in other words when the body when the heart’s relaxed and you know it’s actually feeding itself during diastole with the coronary arteries then that has to do with the stickiness so how thin the blood is is high shear and then the stickiness of it is the low shear portion see you almost have to look at it in two modalities and when you do that that explains why you know we address different things like hydration I just completed a clinical trial a very involved RCT that showed you know the effects of hydration in prevention of hypertension and that was basically again because I was deep making the blood thinner if you will or positively influencing the high shear or the blood viscosity during systole the counter side of that is when people do have blood clots like II you know that’s usually in the heart well that’s usually the stickiness of the blood and you mention that again within you know with the belly fat effect with a number of the different you know the hyperglycemia as you know insulin resistance etc back to these particle size and see that’s what’s exciting see now we look at you know a pattern a pattern B as far as to go to low density lipoproteins well guess what the small dense ones those act they you know when you have high blood viscosity I tell my patients I said it’s like getting sandblasted by really tight you know tiny little bb’s whereas the pattern II small dense those are bad pattern a are big and fluffy so I said would you rather get hit by a BB or would you rather get hit by you know cotton ball with everybody’s a blow cotton ball well that’s the same thing that’s going on so you look at American Heart Association won’t tell you right there on the website there’s just as many people sir come to an acute MI with a class trouble or 150 it’s just much more complicated and you’re certainly on top of it but I really think the blood viscosity sort of adds them you know sort of like Paul Harvey now for the rest of the story so when I see patients I I do it v. App the vertical you know assessment profile and you know Berkeley now got acquired by quest so I my patients to get that done and you know if then that’s what that total tool line look at to determine what I need to do is a particle size and then back it up is there more of a despot you know insulin resistant type of thing so sure and I would love for you to expand on that we mentioned particle size but I just want to make sure everyone knows that we’re talking about Ralph so when you talk about these particles let’s just expand on that what type of particles and you know cholesterol isn’t all the same can you go through that and if you have any analogies kind of like that feh 2 macroglobulin and the fire truck using particles I’d love to hear that as well first of all I’m talking about low density lipoprotein and before you know your conventional doctor if I may would say you know the good classroom was the HD the high density lipoprotein which was again sort of taking the garbage out it’s you know and you mentioned it in the book to again you know most of your cholesterol 80% of it or so is determined by what your liver functions doing or so it’s just a small dietary input with that so soon would you have HDL the good cholesterol and then the LDL would proverbially with the bad cholesterol well I always sort of like I tell my patients well it depends which pattern you have is to which one is you know how bad is it bad you know so LDL is low density lipoprotein and then when they’re very small and dense packages of fats then those are called pattern B and I think they use a lipo for eat they do like electrophoresis in the lab to sort of see the size of the particles so when those small dense ones every time the heart beats they’re slamming into the inside of the blood arteries and those can actually cause what we call sterile inflammatory or ascore EA shion’s they have a high residual a residency time on the endothelium and I can actually has been noted to decrease nitric oxide function and then I not to get too wonky but that’s what allows your blood vessels to you know contract and dilate and when they get really tight and resisting that hypertension goes up and then you know you should start down that road of a throat Genesis so back to those low density these so called bad cholesterol so if you have pattern a those are big and fluffy so again when those get slammed up against the artery they’re really not they’re kissing you know really so it doesn’t cause that damage that we see specifically in the LD L you know pattern BD so you really need size matters initially with cholesterol so you know you need to know how big those core particle sizes are and actually just to give you a little to drive this home if everything was identical in patient labs works were dinner and called everything is identical except they had pad Rijn be bad as the pattern a that would increase their risk of heart attack stroke four fold so that’s why I backed you know that’s why the particle slide but like particle size does matter and again I was really excited because you drove that all home you know adipose tissues behind its own endocrine glands out of control it’s just one fire after another and you really have to break that cycle yeah well said Ralph so one analogy that I’ve been using if we think of like LD L of a hundred well and we think of coins you know if we want to make 100 cents we can have four quarters and that’s 100 cents that equals a dollar another way that we can make a dollar or 100 is 100 pennies now if you were to put four quarters on the floor next to 100 pennies well you can see which one would have more surface area and to get back to what you’re talking about shear and stress and just you know overburdening the car vascular system obviously if you have these little bb’s which would be the hundred the small dense LDLs the the pattern be that we’re referring to that’s gonna cover that’s gonna be the bb’s you know when you talk about the cotton balls that would be like your quarters you know both equal 100 like an LDL of 100 or an LDL of 120 but it’s really the particle size and particle number that people need to be looking at and it’s so funny I have family members that send me their lab work from just an HMO or their you know general you know family doc or internal medicine doctor and nine times out of ten Ralph there’s no expanded lipid test on there it’s just a standard cholesterol test miss it you think Mike I said you know it’s like it doesn’t really mean much I mean really like you said you go on the American Heart Association website and you can see more than 50% of individuals that have a fatal myocardial infarction have so called normal cholesterol so I don’t know when how long it’s going to take to change their paradigm but it’s really interesting it is and you know I I do lots of consults by telephone and etc and we won’t even have a phone call until I see their you know I prefer Berkeley and then their blood viscosity test those men thyroid and you know a lot of other vitamin D levels you know 25 hydroxy excetera you know CRP yeah and it’s just so you know I don’t want to waste my patients time I just say you know this is the bare minimal then we can engage in it you know an effective evaluation in a corrective action plan for that particular patient you know and I look at everything obviously with lifestyle and environmental attributes to etc sure sure you mentioned the blood viscosity test that’s something that you’ve helped to bring to you know commercially to be commercially available let’s talk about that what what is it how can individuals get access to it oh absolutely I used this back in 2001 and just to show you I’ll just you know tell you a quick example I was using a prototype one on an Indian Reservation and what I found out was that was the most when I saw an escalation in blood viscosity I hope that was the single best predictor for me that that patient was insulin resistant of course I worked on an Indian Reservation reservation and so greater than 50 percent of my patients fell into that category but it really I just want to mention that because it really does Drive in what you’re talking about about the insulin sensitivity and then you know it really got in the pi 1 and then you know the small you know particles that pattern B and then that really does increase the thickness of the blood so I helped to get that into a commercial lab it’s FDA approved again you know I’ve been working with you know a number of people leaders in the American Heart Association and they actually are running articles mentioning blood viscosity so you know anybody listening out there feel free to go to WWII in comm and what we’ve done is archived all the research and dealing with whole blood viscosity so you know that’s certainly available for the public to review that’s fantastic now do you have any primary testing modalities or have what remember words which you know hormone expert Jonathan right on this I explore that a little bit and you know how can we access that this test is blood viscosity test oh absolutely yeah among a lot of things that you know having a great honor to work it to Houma and be you know have doctor Jonathan Wright as my preceptor I also was working in the laboratory Meridian Valley lab calm or Meridian Valley because I was there in Seattle because of the innovative nature that lab and dr. Reich quite honestly was very enthusiastic about blood viscosity they were the first laboratory to make this test commercially available and so to go to that website there’s a number of Power. Point and number of presentations for that you know blood viscosity really is where the rubber hits the road I’ll tell my patients you know we’ll work with a lot of different things but I need to know are you in imminent threat of a heart attack stroke you know deep vein blood clot pulmonary emboli and I have ranges just like we have you know different you know ranges for blood pressure I have ranges where I know we call them critical values that’s where the lab calls us at hey Tina this is a life threatening value for it and so it allows me to triage if you will my patient in you know is this someone I can sort of you know put on a fairly no I’m mellow preventive cardiac rehab program or is this like a 911 this guy you know this this patient needs immediate attention to get him out of the danger zone if you will so so that’s you know invaluable and I can’t tell you how many patients you know bit problem whose lives were probably saved by I just I see a time and time again oh that’s amazing no rough is this a blood test or is this some sort of in office procedure oh I’m sorry yeah no it’s a blood test like I said the equipment is FDA approved so what you would do is have that your physician order that for you they would send you out a kit and in there would be a couple of tubes and then you’d have either your doctor’s office or phlebotomist you know draw the draw the blood and then ship it back to the lab and then we would they have consulting physicians that review labs so I train most of them so they could actually interpret those results with the ordering physician and again it’s like the first go to test when I get a consult because you know I need to assess the sense of urgency for this patient’s care oh absolutely what are some things we can do obviously we talked about belly fat and insulin sensitivity and all that but one thing you mentioned in a presentation that I saw you give a couple years ago was is donating blood and exercise do you want to expand on those two things oh absolutely and I have to mention I am completed an article for profusion which is a cardiovascular Journal I know what’s the family medicine guy doing on there right but it was because I had reviewed all the literature and what I found was that patients who donated blood frequently and I just did about three days ago decrease their overall incidence of heart attacks and strokes 88 to 90 percent so put that in perspective if you completely embrace your pharmaceuticals research they’re saying maybe 80 18 to 22 percent with statin drugs there is some validity in that because statin drugs will decrease blood viscosity but I’m just showing you here here’s almost a four full therapeutic benefit by just donating so it’s good for you and it’s good for humanity I mean it’s really hard to go wrong specifically that you know you want to go and do what I call this I’m again I’m assuming you’re a healthy person you know we certainly want to you know our our blood supplies here in the United States is excellent compared to many other countries but Church story is you want to donate two units then we call that two unit donation and you can do that every four months and so really put in three times a year you’re going to be doing a tremendous service for the blood bank and you’re also going to be helping yourself in the prevention of like you said earlier one of the largest causes of death in the industrial nation that’s amazing that’s been I’m not a fan of venipuncture needles but I would like to reduce my risk by 88% so I’m I’m going to do that off I’ll let you guys know how that goes so I hope everyone and it’s free right Ralpha me donating blood is correct excellent service there with that escapes me but I think it’s the Seattle blood bank they don’t quote me but yeah I continued donating when I was there and yeah so you have a tremendous resource you just schedule it and you’re able to do that yeah all right well this has been amazing I really appreciate all the work you’re doing in a true pioneer in both you know enzyme therapy and also blood viscosity so Ralph as we part here I would like to what in the show notes we’ll have your blood flow online calm and ready in Valley lab combat any other websites your personal website or links to your books you want to talk about that now well he helped on vector comm so health and then in vector de sitio are calm yeah I don’t have my own website per se but at least you’ll have access with blood flow online. com with my research that I’ve done blood viscosity and then hydration was the other one if I can just sort of I did a study right there in Seattle with firefighters actually used essential water which is a reduced Oakland ice water and there’s a small pilot study but it showed that we could rehydrate and decrease blood viscosity tremendously so there’s another tool donate blood and drink water I love it all right well thank you so much for joining us again Ralph this was awesome we’ll make this available and really appreciate your time and expertise and thank you for coming on the show well thank you Mike and again you’ve really helped me connect the dots in my area back to you know the other dynamics in the body from you know the indicate that particularly with the adipose tissue so my hats off to you..

A person must have normal blood pressure that is 120/80 mm Hg. Someone with lower blood pressure while donating blood is not suitable for it. Since there are chances that she/he would become hypotensive himself. Also, blood volumes from such a donor may not have the capacity to fight infections in the environment which it moves into.This is NOT something you want to ignore (especially when it can be treated). If you’re struggling with blood pressure take a look at this: Blood Pressure Exercises VSL cbGive the video a watch it might help.If you prefer to read:hey everyone it’s Mike Munsell with high intensity health radio where we cover the best of fitness nutrition and functional medicine so glad that you joined us because today we’re going to talk about heart disease from a totally new perspective really from the angle of physio mechanics and blood viscosity and the stickiness of blood that’s something that a lot of individuals in preventive or integrative medicine are not really talking about and also in the traditional realm those individuals are not talking about that either so we dive into that with my good friend an integrative medicine expert dr. Ralph Holsworth and he knows his firsthand he’s actually an emergency room physician that’s what he does so on this day job so to speak and at night on weekends he’s an avid researcher he’s well published he’s done a lot of research in the field of enzymes proteolytic enzymes we talked about stirrup pep days and nano kinase and we also talked about blood viscosity that’s kind of his new big interest level right now he actually worked with Jonathan Ryan to develop a blood viscosity test that you’ll learn more about why am I making such a big deal by blood viscosity well it’s actually linked with an 88% reduction in heart disease risk if you can lower your blood viscosity so we talked about all these different studies he’s looked at three hundred some odd studies and all and all the different risk factors blood viscosity keeps coming up is even more predictive or more indicative of high cardiovascular risk compared to smoking we know smoking is one of these really problematic risk factors so you’re going to learn a lot about this and therapeutic applications that you can implement in your life the use of enzymes donating blood exercise proper sleep and burning that belly fat to reduce plasminogen activator inhibitor one or pie one that we talked about and I know it’s a mouthful but you’re going to learn more about that so I really hope you enjoyed it if you do please subscribe to the channel you can also listen to this over in i. Tunes or on stitcher high intensity health radio just type that in and you’ll pull it up and you can subscribe there too hope you enjoy and have a great one between diastole and systole or the relaxed and squeezing stages of the heart blood thickens four to six fold if you can imagine the blood sort of starting and stopping and starting and stopping and this sets up the flow dynamics and it’s the really the hemo rheology or the physics of the blood that contributes to a thorough Genesis so once blood becomes thick it actually causes a sterile inflammation on the endothelium then you get what we call endothelial dysfunction which you mentioned very eloquently again in your book welcome to high intensity health radio the best of fitness nutrition and functional medicine and now here’s your host Mike muscle all right welcome back to the whoa and I’m very excited for today’s guest we have with us dr. Ralph Holsworth he’s a proteolytic enzyme expert and also an expert in blood viscosity which is going to be the topic today so get ready for that too dr.Holsworth is a doctor of Osteopathic Medicine and he’s board certified in family medicine as well he has served as the environmental scientific consultant for the EPA the Environmental Protection Agency an honorary professor at the university of colorado department of biology and multiple other publications and so for that dr. ralph will get into you but dr: ralph welcome thank you really appreciate this opportunity yeah I’m very excited to chat with you we’ve known each other I think since oh seven and you know we’ve both lived in Colorado and then you were in Seattle and then now you’re back in Colorado though let’s talk about your background your work with enzymes and then how you’ve transitioned to be an expert in blood viscosity and you bet I went to medical school in during medical school I actually had a friend of mine give me a book and it’s called enzymes the fountain of life well David Williams was one of the authors and so you know one of my bad habits is when I read a book or something that excites me which that book did profoundly I will call up the author and try to get more information and so that led into an academic relationship with dr. Williams who is a MD Ph. D he was an oncologist one of the top doctors involved with Cancer Treatment Centers of America and then Blum behold he introduced me to dr. Carl Ron Berger Ph. D and of course you’ve heard of MU Coast pharmaceutical the German company which actually the woman’s I’m so that’s really how I got into enzymes now reading a book and digging a little bit deeper and trying to meet the people in the know and I credit dr. Carl Ron’s burger for giving me a tremendous amount of the direction in looking at the clinical applications in their therapeutic attributes of it and oh probably about three or four months prior to his death he had mentioned thatl kinase and he’d actually which was entered was sort of out of character German researcher he was very keen on sticking on task and just you know did tremendous amounts of research willful a bit lobe enzyme so for him to bring natto kinase up I thought while there’s something there so I credit him also for allowing me to go over to Japan and make and meet doctor who yogi Sumi I’ve met with him twice and that continued my pathway especially after his departure fascinating that I knew that we would get along and be good friends that when we first spoke on the phone and this was I think a Friday afternoon and you you’re doing hospital work at a time and then you said yeah well my weekends are really devoted to studying and research and at the time that’s all I was doing as well so as you’re also working in the hospital setting what is X are you doing there well I work in a very small rural setting and I cover the emergency room 24/7 for about 12 days and that allows me to just stay up to date with a lot of therapeutics and allows me to basically get the research from you know we always say from the bench top to the bedside and so that’s I think really integral that I’m grounded there I see the inadequacies and and sometimes just where we can you know do a better job and so that’s what I get to do and I really enjoy it in a very small rural community in Colorado that’s great now do you get to use any of these enzymes that you studied clinically at the hospital or is that more in your outpatient if you do see patients on the side how does that work well I don’t use them in the emergency room per se but I did have quite a few clinical patients so I actually do three things and it sounds little you know it’s not multitask but I do cover the ER I do have clinic patients and I also admit people to the hospital so and so during that time yes absolutely I’ve been able to use enzymes and then some integrative therapy IV blue Payan phosphatidylcholine you know the buter rates a number of integrated vitamins ascorbic acid so yeah they’re very I’ll call tolerance of my food but it’s all supportive and I just have more tools in my tool bag and so my patients really appreciate that and that’s who I’m always striving to meet their expectations to you know help them along their health journey yeah that’s fascinating so let’s dive into blue analytic enzymes and what are they and how do they work a lot of people think if you take an enzyme it’s gonna be broken down by hydrochloric acid in the GI tract but we know that not to be true so let’s walk us through the science here and talk about some of the most potent ones that people can take oh absolutely so there’s a number of different broad categories they actually have different numbers it’s sort of like a zip code and each number tells exactly what it cleaves or what it breaks off from a protein so for the most part all the therapeutic enzymes that we use are from a large classification called class three which are called hydro lays and what that means that anything first I should preface anything that ends in ASE suffix usually biochemically suggests that it is an enzyme there are always exceptions but the modern nomenclature dictates to that so we have hydrolyze and what that means simply is that they’re going to break a protein open and put a water molecule so I tell everyone think of proto like enzymes as having a water X they’re going to break the protein down but putting in a water molecule now of course different enzymes do that in different manners in ways so there’s you know we break those down into further classifications from that so but the majority of them were what we call endo peptidase meaning in de meaning they cleave inside bonds not EXO in other words the ones on the outside of a long protein chain okay so these musically cleave the water and that’s how are able to break up larger molecules in a smaller component their component parts yeah they cleave the proteins but they do it by putting in a water molecule and and I should say that that is a biochemical catalyst in other words that there are chemical reactions in the body as you know with your background that would never ever happen unless there was an enzyme you know taking the you know product a to product B substrate that’s great those trypsin chymotrypsin their syrup peptidase and then nano kinase I’d like to talk about that at the end because they’ll give us a nice segue into blood viscosity but let’s talk about some of the new enzymes that are out there and maybe potentially better than that so anything on just the basics of trypsin chymotrypsin engine and then also of syrup peptidase that you want to speak to oh absolutely and you mentioned earlier at which I thought was very adroit was that you know the common perception is that these enzymes are broken down by hydrochloric acid well that’s there are some that had sensitivities to stomach ph’s but in the large part these enzymes are shuttled into the immune system through the Gulf yeah which is God associated lymphoid tissue and they bind immediately to the immune system so very similar to a infant breastfeeding you know it’s getting its Ig. A secretion to come in you know it’s getting that from the breast milk so again very similar that we do know and it’s been very well documented that we do have endogenous activities from enzymes that we ingest in our systems so and they go right into the immune system so in contrast with pharmaceutical drugs which is you know portal they go through the p450 liver well you know phase 1 phase 2 breakdown and then it’s really the byproducts or metabolites that cause the effects of pharmaceutical drugs enzymes pretty much go right into the immune system and I think that’s why we see generally you know I personally have to witnessed any adverse drug reactions if you will to in these lines because of that ability to you know identify if you will with the immune system well so we’re bypassing the whole liver you know detoxification pathways and going is it the doctor Holdsworth going through the lymphatic vessels and right into the immune system that way exactly the microcosm and there’s a particular I call it the enzyme bus if you will those are called alpha 2 macroglobulin and I tripped today’s so there’s various different ones for it but for the most part alpha 2 macroglobulin it’s basically a Venus flytrap mechanism it’s a very large protein it actually has a little bait a little trigger your protease enzymes will actually trigger that and then you’ll see that that activates it it clamped down on it like the vena you know ie the fly being the enzyme and the Venus flytrap being this alpha 2 macroglobulin and then that shuttles it to where it needs to be in the body and you’ll hear some late people mention the intelligence of enzymes then I think academically I’m ok with that because there is an intelligence because it is basically going right into the immune system and assisting whatever the immune systems major task is so I tell a lot of people if you want to go to a flyer you know chances are if you jump on a fire truck with bells and sirens going you’re going to end up in a fire same thing Keva enzymes a couple onto this alpha 2 macroglobulin fire truck they’re going to go to your tinnitus of inflammatory wherever that is in the body and when they get there we’re talking about adding water molecules to break up proteins what exactly are these proteins are these you know inflammatory proteins created by the immune system and what are we how does it reduce inflammation or improve mobility or you know any of the other you know benefits that’s an excellent question and it’s a little bit calm but the short story is that it revs up the immune so technically enzymes are called biological response modulators so that’s a certain category that it may neither is a specific immune stimulator nor suppress it it just does the right thing when it needs to be so absolutely the other thing when you bind this the altitude macro problem it goes from a slow stage to a fast stage so what that means is is taking the garbage out instead of doing it once a week it’s doing it once every hour or ever I mean my analogy is you know and that’s a general analogy but what that’s doing is taking out these immune complexes this crosstalk that we see in autoimmune diseases and cancer in cardiac diseases so you’re absolutely correct it has a significant direct and indirect you know effect on the immune system but overall it’s very therapeutic for the body sure and what about them you know post injury people roll their ankle sprain their wrist that’s something like that where there’s a lot of localized inflammation what do you generally recommend in terms of dosing empty stomach full stomach how many times a day what would be your general protocol there well my general protocol is an ER doc I think getting away from instead completely you know I do have taken some training in pro law therapy and that’s really even focus my attention that I can’t delay the inflammatory process you know it’s been with us for thousands and thousands of years it’s really why we’re here today it’s it’s a success story as far as you know as humans are concerned in any mammal but to the short story is that when you take enzymes that’s going to push you through the inflammatory and actually cut your healing time if you will about 50% that was well documented in at least 2030 things that I know uh but to answer your other question bromelain is what I usually recommend and you know you can take some of these enzymes you know I think a lot of them you know with one benzine they had recommended that that be on an empty stomach I’d eat one hour before two hours after that’s important that it has more to do specifically with some of the enzymes in that formulation that are not tolerant to the p. H and that it’s different for different enzymes so you can’t always recommend you know taking them on an empty stomach specifically with nattokinase I know there’s still some confusion in you know amongst some of the health professionals regarding that so sure no what about syrup peptidase I know that’s one that has a lot of research for maybe biofilm and things of that sort any updates from your perspectives I find it amazing enzyme you know because it’s you know specifically it’s a mucolytic I mean that’s what I’ve used it with chronic sinusitis I’ve used it with any better with COPD reactive airway disease is you know bronchiectasis interesting enough and Japan you know they really look at enzymes as being a pharmaceutical drug and there’s actually one enzyme it’s a type of sera peptidase that they actually have combined with an antibiotic and it’s specific uses for sinusitis it increases the bioavailability again if I can refer back to my previous explanation of how enzymes are picked up by the immune system the altitude microbiome etc that makes you know a little dab will do it in other words it enhances the availability and whatever you like that previous antibiotic it helps penetrate the sinuses which can be sort of an immune privileged area in a lot of humans or why did you mention the biofilms you know that’s a classic area for biofilms as well as the biliary tree you know so excellent point when it’s available now is the ability to instead of use the enteric coating which I know entire coating there’s a lot of heat involved from a manufacturing standpoint the ability to use acid resistant vegetable capsules so mentioned that the caustic p. H of the stomach may be certain enzymes are intolerant to that so one way to bypass that is the acid resistant veggie caps that disperse in a small intestine have you looked at that research it on it’s been some time I’ve looked at it but yes I have a lot of things that specifically with nano kinase I’ve looked at a lot of you know pharmacokinetics as far as you know delivery and the reason is you know I think there should be two types of natto kinase and I apologize I’m jumping ahead but I do know there’s a preventive modality for natto kinase and others also a therapeutic in other words I’ll call it a nine one one type of use of metal kinase because you know as a doctor I’ve used it in the emergency room that’s investin settings very rural settings where I didn’t have recombinant TPA or what we call clot Buster’s so great well let’s segue right into natto kinase and talk more about that so two different forms for two different applications she’s going to get into those a little more depth yeah I think it’s just the time of onset we know once you put natto kinase in your mouth it’s sort of the activity in your bloodstream in other words maximum clot busting capacity if you will sort of Peaks around six hours so someone in atrial fibrillation someone at a high risk or susceptible for a CVA or stroke heart attack blood clot etc then I’m recommending they dose qid four times a day particularly at bedtime because you know there’s a thing called pi 1 its Pai 1 which is plasminogen activations inhibitor when that sort of increases that’s when we see people presenting with their heart attacks and strokes and you actually reference I believe you know what we call Black Monday in other words there’s a statistical proportion of males who have acute MI heart attacks on Monday and again this is a lot of that is secondary to max inflammation sort of the parasympathetics and the PI one being at its elevated level in the human so wow that’s great so the nano kindness is it affecting pi 1 or is it just helping with the the viscosity d what is it doing exactly oh that’s a great question it’s doing both and that’s why I’m so excited about it because not only is it it’s got a little pac man you know about 10% of the modus operandi is you know eating chewing up it is very specific let me back up one second here it’s very specific for cross linked vibrant I mean if it was a pacman that’s all it would eat would be cross linked vibrant so that’s very good it’s not in it’s not in there eating chewing up your albumin or chewing up any other type of proteins that your body needs so let me qualify that from the beginning secondarily 10% is actually chewing on the clot but the majority of the action just like you said has to do with that it revs up your pot your ability and it revs up to your kinase as Webb’s up your plasmid all those are or enzymes that your body makes so it was a synergy and it up regulates all that so it’s really nurturing Nature’s Way I ensure I pledge rise that from someone but the short story is you know it really does put your body in a super defensive mode to break up any clot that may form and you know I’m just seeing some remarkable cases that you know as a physician overseeing it and wide variety of patients great so I haven’t looked at blood discuss in in a long time but fibrin would be bad plasminogen would be good it’s as leak exactly so exact plasminogen so the activator inhibitor pi is inhibiting plasminogen activation so that’s why it’s bad so in turn no sleep app you have belly fat inflammation diabetes and so on are all linked with PI being activated by one which is going to make one more viscous and increased risk for various cerebral vascular cardiovascular diseases is that where we’re going that’s absolutely correct and that’s really why when I read your book the belly fat effect I got so excited because I was like oh okay here’s how this comes home you know this really for me at least academically sort of you know pulled it all together for me like you said you know these are things we general protocols and practices we know to be generally accepted as a good thing but now what you presented and I was impressed with company preferences you had with that book was you know here it is here’s the science here’s the research so you know that that’s where I have to hang some well thanks so much that took a while it took many weekends and yeah I’m glad that you found it helpful and hopefully other people will find it helpful as well so yeah we know dr. Hall’s worth car vascular diseases continues to be the number one killer worldwide and we’ve been talking about thick blood and so forth let’s define blood viscosity and what that is and why that’s so problematic for our vessels and arterial system absolutely another book I read in another author and I have to give him credit was dr. Kim Kinsey cardiologist he did a lot of research with a dr.Jung Cho I continue to research with dr. Jung Cho the medical school I was like there was seem to be just a litany of different things that created cardiovascular disease well and again the common denominator that pulled this all together was you know blood viscosity there’s 300 independent cardiac risk factors if you look at the common denominator in each and every time it is old blood viscosity so it’s actually more sensitive than whether a patient smokes or doesn’t smoke and I’ll be glad to share all those references and research so the other thing that gave me not to digress too much was you know Iran nuclear reactors in the Navy so I learned a little bit about fluid mechanics and so once I met with dr: Kinsey a cardiologist and then dr. Jung Cho a physicist both leading experts in blood viscosity then I was able to really apply a lot of the retrofit if you will some of my previous knowledge from the Navy and applied that you know basically you know run a tan reactor and preventing corrosion and apply that to the human circulatory system and their nurse differences number one blood is a non newtonian fluid meaning that when you put sheer into it it changes so probably the one that a lot of people niching take is ketchup and ketchup you turn the bottle upside down it doesn’t flow very well but give it a little jerk and it starts to flow well that’s very similar to the flowing I mean that’s a non newtonian fluid once you impart shear or energy into it and it starts to flow so between diastole and systole or the relaxed and squeezing stages of the heart blood thickens four to six fold if you can imagine the blood sort of starting and stopping and starting and stopping and this sets up the flow dynamics and it’s really the hemo rheology or the physics of the blood that contributes to a thorough genesis that’s not to say I don’t completely agree with everything that Faust and the vulnerable plaque and the traditional biochemical models say of how plaque begins I’m just backing the starting line if you will into the blood stream so once blood becomes thick it actually causes a sterile inflammation on the endothelium and you get what we call an ethereal dysfunction which you mentioned very eloquently again in your book so you know it all ties in again so I’m also looking at the physics and what’s very exciting you know to bring this home what’s exciting about nano kinase is that my clinical research showed that it decreased blood viscosity where up to 18 to 20 percent so a huge benefit as far as not filling the blood technically you know but allowing it to flow but I mean you know the bodies that able clop just as efficiently when it’s on that’ll kinase it’s just that the physical thickness of it is you know 18 20 percent decreased this is really interesting Ralph and until you bring up a huge you know curveball on the whole lipid hypothesis of cardiovascular disease because like you said we’ve been focused so much on the biochemical the cholesterol the triglycerides the lipids even hypertension but now we we dig deeper and can you know quantify this and I would love for you to talk more about that more about this blood viscosity so basically you know during contraction we have a you know the sheer mechanics change the whole hemodynamics and that creates it just a localized inflammation and in the vascular system is that what I’m hearing absolutely and it occurs in very particular areas and it’s a little bit more complicated because remember I said blood has different viscosity so when it’s getting ejected out of the left ventricle into the descending aorta etc then it that’s what we call high shear so it’s moving very quickly it has a lot of energy so that’s when we see a lot of arterial sclerosis in other words the stretching of the vessels I guess the easiest way to say this is that when you you know it has a lot to do with the thinness of the blood and then the other side of it the low shear in other words when the body when the heart’s relaxed and you know it’s actually feeding itself during diastole with the coronary arteries then that has to do with the stickiness so how thin the blood is is high shear and then the stickiness of it is the low shear portion see you almost have to look at it in two modalities and when you do that that explains why you know we address different things like hydration I just completed a clinical trial a very involved RCT that showed you know the effects of hydration in prevention of hypertension and that was basically again because I was deep making the blood thinner if you will or positively influencing the high shear or the blood viscosity during systole the counter side of that is when people do have blood clots like II you know that’s usually in the heart well that’s usually the stickiness of the blood and you mention that again within you know with the belly fat effect with a number of the different you know the hyperglycemia as you know insulin resistance etc back to these particle size and see that’s what’s exciting see now we look at you know a pattern a pattern B as far as to go to low density lipoproteins well guess what the small dense ones those act they you know when you have high blood viscosity I tell my patients I said it’s like getting sandblasted by really tight you know tiny little bb’s whereas the pattern II small dense those are bad pattern a are big and fluffy so I said would you rather get hit by a BB or would you rather get hit by you know cotton ball with everybody’s a blow cotton ball well that’s the same thing that’s going on so you look at American Heart Association won’t tell you right there on the website there’s just as many people sir come to an acute MI with a class trouble or 150 it’s just much more complicated and you’re certainly on top of it but I really think the blood viscosity sort of adds them you know sort of like Paul Harvey now for the rest of the story so when I see patients I I do it v. App the vertical you know assessment profile and you know Berkeley now got acquired by quest so I my patients to get that done and you know if then that’s what that total tool line look at to determine what I need to do is a particle size and then back it up is there more of a despot you know insulin resistant type of thing so sure and I would love for you to expand on that we mentioned particle size but I just want to make sure everyone knows that we’re talking about Ralph so when you talk about these particles let’s just expand on that what type of particles and you know cholesterol isn’t all the same can you go through that and if you have any analogies kind of like that feh 2 macroglobulin and the fire truck using particles I’d love to hear that as well first of all I’m talking about low density lipoprotein and before you know your conventional doctor if I may would say you know the good classroom was the HD the high density lipoprotein which was again sort of taking the garbage out it’s you know and you mentioned it in the book to again you know most of your cholesterol 80% of it or so is determined by what your liver functions doing or so it’s just a small dietary input with that so soon would you have HDL the good cholesterol and then the LDL would proverbially with the bad cholesterol well I always sort of like I tell my patients well it depends which pattern you have is to which one is you know how bad is it bad you know so LDL is low density lipoprotein and then when they’re very small and dense packages of fats then those are called pattern B and I think they use a lipo for eat they do like electrophoresis in the lab to sort of see the size of the particles so when those small dense ones every time the heart beats they’re slamming into the inside of the blood arteries and those can actually cause what we call sterile inflammatory or ascore EA shion’s they have a high residual a residency time on the endothelium and I can actually has been noted to decrease nitric oxide function and then I not to get too wonky but that’s what allows your blood vessels to you know contract and dilate and when they get really tight and resisting that hypertension goes up and then you know you should start down that road of a throat Genesis so back to those low density these so called bad cholesterol so if you have pattern a those are big and fluffy so again when those get slammed up against the artery they’re really not they’re kissing you know really so it doesn’t cause that damage that we see specifically in the LD L you know pattern BD so you really need size matters initially with cholesterol so you know you need to know how big those core particle sizes are and actually just to give you a little to drive this home if everything was identical in patient labs works were dinner and called everything is identical except they had pad Rijn be bad as the pattern a that would increase their risk of heart attack stroke four fold so that’s why I backed you know that’s why the particle slide but like particle size does matter and again I was really excited because you drove that all home you know adipose tissues behind its own endocrine glands out of control it’s just one fire after another and you really have to break that cycle yeah well said Ralph so one analogy that I’ve been using if we think of like LD L of a hundred well and we think of coins you know if we want to make 100 cents we can have four quarters and that’s 100 cents that equals a dollar another way that we can make a dollar or 100 is 100 pennies now if you were to put four quarters on the floor next to 100 pennies well you can see which one would have more surface area and to get back to what you’re talking about shear and stress and just you know overburdening the car vascular system obviously if you have these little bb’s which would be the hundred the small dense LDLs the the pattern be that we’re referring to that’s gonna cover that’s gonna be the bb’s you know when you talk about the cotton balls that would be like your quarters you know both equal 100 like an LDL of 100 or an LDL of 120 but it’s really the particle size and particle number that people need to be looking at and it’s so funny I have family members that send me their lab work from just an HMO or their you know general you know family doc or internal medicine doctor and nine times out of ten Ralph there’s no expanded lipid test on there it’s just a standard cholesterol test miss it you think Mike I said you know it’s like it doesn’t really mean much I mean really like you said you go on the American Heart Association website and you can see more than 50% of individuals that have a fatal myocardial infarction have so called normal cholesterol so I don’t know when how long it’s going to take to change their paradigm but it’s really interesting it is and you know I I do lots of consults by telephone and etc and we won’t even have a phone call until I see their you know I prefer Berkeley and then their blood viscosity test those men thyroid and you know a lot of other vitamin D levels you know 25 hydroxy excetera you know CRP yeah and it’s just so you know I don’t want to waste my patients time I just say you know this is the bare minimal then we can engage in it you know an effective evaluation in a corrective action plan for that particular patient you know and I look at everything obviously with lifestyle and environmental attributes to etc sure sure you mentioned the blood viscosity test that’s something that you’ve helped to bring to you know commercially to be commercially available let’s talk about that what what is it how can individuals get access to it oh absolutely I used this back in 2001 and just to show you I’ll just you know tell you a quick example I was using a prototype one on an Indian Reservation and what I found out was that was the most when I saw an escalation in blood viscosity I hope that was the single best predictor for me that that patient was insulin resistant of course I worked on an Indian Reservation reservation and so greater than 50 percent of my patients fell into that category but it really I just want to mention that because it really does Drive in what you’re talking about about the insulin sensitivity and then you know it really got in the pi 1 and then you know the small you know particles that pattern B and then that really does increase the thickness of the blood so I helped to get that into a commercial lab it’s FDA approved again you know I’ve been working with you know a number of people leaders in the American Heart Association and they actually are running articles mentioning blood viscosity so you know anybody listening out there feel free to go to WWII in comm and what we’ve done is archived all the research and dealing with whole blood viscosity so you know that’s certainly available for the public to review that’s fantastic now do you have any primary testing modalities or have what remember words which you know hormone expert Jonathan right on this I explore that a little bit and you know how can we access that this test is blood viscosity test oh absolutely yeah among a lot of things that you know having a great honor to work it to Houma and be you know have doctor Jonathan Wright as my preceptor I also was working in the laboratory Meridian Valley lab calm or Meridian Valley because I was there in Seattle because of the innovative nature that lab and dr.Reich quite honestly was very enthusiastic about blood viscosity they were the first laboratory to make this test commercially available and so to go to that website there’s a number of Power. Point and number of presentations for that you know blood viscosity really is where the rubber hits the road I’ll tell my patients you know we’ll work with a lot of different things but I need to know are you in imminent threat of a heart attack stroke you know deep vein blood clot pulmonary emboli and I have ranges just like we have you know different you know ranges for blood pressure I have ranges where I know we call them critical values that’s where the lab calls us at hey Tina this is a life threatening value for it and so it allows me to triage if you will my patient in you know is this someone I can sort of you know put on a fairly no I’m mellow preventive cardiac rehab program or is this like a 911 this guy you know this this patient needs immediate attention to get him out of the danger zone if you will so so that’s you know invaluable and I can’t tell you how many patients you know bit problem whose lives were probably saved by I just I see a time and time again oh that’s amazing no rough is this a blood test or is this some sort of in office procedure oh I’m sorry yeah no it’s a blood test like I said the equipment is FDA approved so what you would do is have that your physician order that for you they would send you out a kit and in there would be a couple of tubes and then you’d have either your doctor’s office or phlebotomist you know draw the draw the blood and then ship it back to the lab and then we would they have consulting physicians that review labs so I train most of them so they could actually interpret those results with the ordering physician and again it’s like the first go to test when I get a consult because you know I need to assess the sense of urgency for this patient’s care oh absolutely what are some things we can do obviously we talked about belly fat and insulin sensitivity and all that but one thing you mentioned in a presentation that I saw you give a couple years ago was is donating blood and exercise do you want to expand on those two things oh absolutely and I have to mention I am completed an article for profusion which is a cardiovascular Journal I know what’s the family medicine guy doing on there right but it was because I had reviewed all the literature and what I found was that patients who donated blood frequently and I just did about three days ago decrease their overall incidence of heart attacks and strokes 88 to 90 percent so put that in perspective if you completely embrace your pharmaceuticals research they’re saying maybe 80 18 to 22 percent with statin drugs there is some validity in that because statin drugs will decrease blood viscosity but I’m just showing you here here’s almost a four full therapeutic benefit by just donating so it’s good for you and it’s good for humanity I mean it’s really hard to go wrong specifically that you know you want to go and do what I call this I’m again I’m assuming you’re a healthy person you know we certainly want to you know our our blood supplies here in the United States is excellent compared to many other countries but Church story is you want to donate two units then we call that two unit donation and you can do that every four months and so really put in three times a year you’re going to be doing a tremendous service for the blood bank and you’re also going to be helping yourself in the prevention of like you said earlier one of the largest causes of death in the industrial nation that’s amazing that’s been I’m not a fan of venipuncture needles but I would like to reduce my risk by 88% so I’m I’m going to do that off I’ll let you guys know how that goes so I hope everyone and it’s free right Ralpha me donating blood is correct excellent service there with that escapes me but I think it’s the Seattle blood bank they don’t quote me but yeah I continued donating when I was there and yeah so you have a tremendous resource you just schedule it and you’re able to do that yeah all right well this has been amazing I really appreciate all the work you’re doing in a true pioneer in both you know enzyme therapy and also blood viscosity so Ralph as we part here I would like to what in the show notes we’ll have your blood flow online calm and ready in Valley lab combat any other websites your personal website or links to your books you want to talk about that now well he helped on vector comm so health and then in vector de sitio are calm yeah I don’t have my own website per se but at least you’ll have access with blood flow online. com with my research that I’ve done blood viscosity and then hydration was the other one if I can just sort of I did a study right there in Seattle with firefighters actually used essential water which is a reduced Oakland ice water and there’s a small pilot study but it showed that we could rehydrate and decrease blood viscosity tremendously so there’s another tool donate blood and drink water I love it all right well thank you so much for joining us again Ralph this was awesome we’ll make this available and really appreciate your time and expertise and thank you for coming on the show well thank you Mike and again you’ve really helped me connect the dots in my area back to you know the other dynamics in the body from you know the indicate that particularly with the adipose tissue so my hats off to you..