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PDF Editor FAQ

How much caffeine can your body take before it can be considered an overdose?

All that matters is the dose of caffeine ingested, not the way you take it.From Medscape: Medscape Access Caffeine Toxicity (am not sure if it is publicly accessible, or only for med students, nurses, dentists, physiotherapist, docs and the like who must register first):Caffeine is present in concentrated forms in over-the-counter products, such as alertness-promoting medications (eg, NoDoz, Vivarin), menstrual aids (eg, Midol), analgesics (eg, Excedrin, Anacin, BC Powder), and diet aids (eg, Dexatrim). Caffeine is also a component of prescription medications (eg, Fioricet, Cafergot) and herbal preparations.Caffeine has differing CNS, cardiovascular, and metabolic effects based on the quantity ingested. Average doses of caffeine (85-250 mg, the equivalent of 1-3 cups of coffee) may result in feelings of alertness, decreased fatigue, and eased flow of thought. High doses (250-500 mg) can result in restlessness, nervousness, insomnia, and tremors. In high doses, caffeine can cause a hyperadrenergic syndrome resulting in seizures and cardiovascular instability.Caffeine is rapidly and completely absorbed from the GI tract; it is detectable in the plasma 5 minutes after ingestion, with peak plasma levels occurring in 30-60 minutes.Caffeine is primarily metabolized by the cytochrome P450 (CYP) oxidase system in the liver. The plasma half-life of caffeine varies considerably from person to person, with an average half-life of 5-8 hours in healthy, nonsmoking adults. Caffeine clearance is accelerated in smokers; clearance is slowed in pregnancy, in liver disease, and in the presence of some CYP inhibitors (eg, cimetidine, quinolones, erythromycin). In addition, the hepatic enzyme system responsible for caffeine metabolism can become saturated at high levels, resulting in a marked increase in serum concentration with small additional doses.Death from caffeine toxicity is rare, but it has been reported due to rhythm disturbances, seizures, and aspiration of emesis. Oral doses of caffeine greater than 10 g can be fatal in adults. The average daily adult intake should generally be less than 500 mg/d.Acute toxicity can occur after intentional or unintentional ingestion. OTC alertness-promoting medications are often implicated in intentional overdoses.Certain medications, such as CYP inhibitors (eg, cimetidine) and oral contraceptives, impair caffeine metabolism.Caffeine clearance is reduced in patients with chronic liver disease, in pregnant women, and in infants.Caffeine clearance is increased in smokers. With a stable amount of ingestion, serum caffeine concentrations can double in patients who stop smoking.

What precautionary health screening or tests would you recommend for a seemingly healthy 50 year old?

Only periodic blood pressure measurements, otherwise none, since it has been proven not to lower one’s mortality rate overall, nor that due to cardiovascular diseases and cancer, see General health checks in adults for reducing morbidity and mortality from disease: Cochrane systematic review and meta-analysisGeneral health checks did not reduce morbidity or mortality, neither overall nor for cardiovascular or cancer causes,Of course one should follow all national screening programs in place, e.g. that for colon cancer screening (preferably by colonoscopy) from the age of 40 yo, screening for early breast cancer by mammography in females (when and how often depends on the country you’re in), for females screening cervical swabs for HPV and precursors of cervical cancer (from 30 yo, if HPV negative every 5 years)..Better follow what has been proven to add many life years if starting to adhere to these lifestyle modification starting from around 40 yo, 14 years in females, 10.2 years in males, according to Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population:DO NOT SMOKE!Regularly exercise at least 150 minutes a weekDon’t grow fat, keep your BMI between 18.5 to 24.9 kg/m2Follow a healthy diet, the only evidence proven one being the Mediterranean diet (reflecting the diet of poor Cretans in the forties) consisting of mainly large amounts of fresh veggies, fruits, seed, nuts, fish, olive oil, a little red wine, no red meat, no dairy, and especially no processed foods.Limit your alcohol intake: females < 1 U/day, males <2 U/day.But this means you having to actively do something about your health, are you up to it? Or would you rather have useless periodic check-ups done, a typical US piece of medical theatre, giving you a false feeling of “security”, and if needed a pill from your doc?

My father has high blood pressure too often, how can I help him best?

One either has high blood pressure or one doesn't, so what do you mean by "has high blood pressure too often"? Do you mean his blood pressure results varies? That it is well controlled (<140/90 mmHg) and then he stops his med so it rises again (as it always will, you can't cure high blood pressure)?Some patients just stop using their prescribed meds due to side effects or too high costs, without telling their doc, even reneging on follow-up appointments because they're mad at their doc, or are ashamed of what they did, while they should have discussed this with their docs so other (or cheaper) meds could have been prescribed.Do see the excellent Michael Soso's answer to My father has high blood pressure too often, how can I help him best?He needs to have a medical doctor helping him to deal with his high blood pressure, after it has been ascertained that it really is elevated by repeating the taking of blood pressure with 1 to 2 minute intervals until one finds two values less than 5% apart, the mean value of these two we consider to be the "true" value of that moment, this because the first measured value often is falsely elevated e.g. because the person is tensed because of her/his blood pressure being taken. One raised mean value isn't enough to diagnose high blood pressure, at different times this set of measurements need to be repeated, only after the mean values of 4 successive measurement as done above are above 140/90 mmHg can one diagnose hypertension. From the 1980 Australian Therapeutic Trial in Mild Hypertension see http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2880%2991730-4/abstract we know that around 20% of the participants after having a too high blood pressure on three consecutive occasions, from the 4th on all other measurements were lower than that needed to be included in the trial so weren't included.Buying a properly validated home blood pressure monitor for around USD 100,- the list of which can be found on dabl Educational Trust|Monitors for Self-measurement of Blood Pressure (SBPM) can be helpful. DON'T buy an el cheapo unvalidated one because it was cheap, not being validated you don't know what the values measured means (that is what unvalidated means).If high blood pressure has been properly diagnosed, then you can help him by encouraging him to take his meds regularly, not thinking that he can stop his meds whenever his blood pressure has normalized due to drug use, an often heard misconception.You should encourage him to:stop smoking, which lowers blood pressure by 2 - 4 mmHg after 1 week of smoking cessation, and appreciably lowers his risk for cardiovascular problems like stroke, heart attack etc., docs treat high blood pressure try to prevent. From this 2015 paper Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium | The BMJ "Random effects meta-analysis of the association of smoking status with cardiovascular mortality yielded a summary hazard ratio of 2.07 (95% CI 1.82 to 2.36) for current smokers and 1.37 (1.25 to 1.49) for former smokers compared with never smokers." So smoking cessation is rewarded by a 63% fall in excess mortality caused by smoking.lose weight, each 10 kg weight loss (eat less, don't snack, no soft drinks) lowers blood pressure by 5 - 20 mmHglimit alcohol intake to 2 U/day, lowers blood pressure by 2 - 4 mmHgregular physical exercise, lowers blood pressure by 2 - 4 mmHg. This recent paper Low- and High-Volume of Intensive Endurance Training Significantly Improves Maximal Oxygen Uptake after 10-Weeks of Training in Healthy Men showed that "Both 1-AIT and 4-AIT decreased mean arterial blood pressures, by ∼6 mmHg [−13.0, 0.3) (Table 1) group differences, p = 0.99]. Systolic blood pressure decreased with 6.2 (−11.4, −0.9) and 3.2 (−8.1, 1.7) (group differences, p = 0.84) mmHg in 1-AIT and 4-AIT respectively, whereas diastolic blood pressure decreased with 7.7 (−15.1, −0.3) and 6.3 (−13.2, 0.5) (group differences, p = 0.79) mmHg in 1-AIT and 4-AIT respectively (Table 1)" 1 AIT = 4 minutes of submaximal exertion, in the 4 AIT group 4 of such periods interspersed with 3 minutes of lower (at 70% maximal exertion) exertion periods in between. Participants exercised 3x/week.moderately low sodium diet <6 grams/day, lowers blood pressure by 2 - 8 mmHgDASH diet see Description of the DASH Eating Plan lowers blood pressure by 8 - 14 mmHgavoid licorice (which causes high blood pressure)doing relaxation exercise (or yoga) has also been shown to lower blood pressure by around 5 mmHg, its effects persist after > 5 years of relaxation exercises.Numbers taken from Implementing Lifestyle Medicine in Hypertensive PatientsAll the best!

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