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PDF Editor FAQ

How does the number and percent of glial cells in the brain change as one ages?

First, an explanation of glial cells is in order. They have traditionally been ascribed supportive roles in the nervous system, and number on average roughly equal to the 86 billion neurons in the adult brain. There are several types of glial cells. The main ones are listed below.Microglia are derived from hematopoietic cells and scavenge for plaques, damaged neurons and infectious agents. They comprise 10-15% of all brain cells.Oligodendrocytes insulate axons with a myelin sheath to promote more efficient propagation of electrical impulses. They are the most numerous of the glial cells.Astrocytes regulate the ion balance surrounding neurons. They also help clear the neurotransmitters released by neurons, modulate synaptic function, regulate blood flow, and appear to form the basis of the blood-brain barrier. They comprise 17% of glia in the cerebral cortex. Astrocytes also participate in nervous system repair, store reserve fuel for neurons in the form of glycogen, and have been shown to secrete gliotransmitters (as opposed to neurotransmitters) to chemically communicate between themselves and with neurons. They may have a role in learning, memory, autism and schizophrenia.Glial cells, unlike most neurons, are mitotically active. They are present in different proportions in the different regions of the brain.There are, as yet, few studies investigating the impact of aging on glial populations, probably because their importance had been previously underestimated.One such study in 2002 examined the number and proportions of glial cells in the optic nerves of young versus old Rhesus monkeys. I quote:"Oligodendrocytes and microglia both become more numerous with age... Overall, in the old animals, there is a slight decrease in the percentage of astrocytes, a slight increase in the percentage of microglia, and little change in the proportion of oligodendrocytes. None of these differences were statistically significant... (whereas) optic nerve fibers are lost..."[PDF]Effects of age on the glial cells in the rhesus monkey ...In contrast, a 2013 study regarding neuronal and glial populations in the neocortex of elderly women found no difference in the number of neurons between subjects in the 65-75 y/o age group and the 95-105 y/o age group. There was a statistically significant decrease in oligodendrocytes in the older age group. Effect of age on neocortical brain cells in 90+ year old human females-a cell counting study.We have only begun to understand the role of glia in brain function and in the causation of neurologic disease, and are still far from deriving any clinical applications.

What is the process of making a physically handicapped certificate?

Visit hometown government district hospital e.g. Sadar Hospital of district. Register your personal details and concerned department related to your disability at a registration counter. After paying a nominal fee of ₹1 to ₹5 you got a registration slip.Please check the registration details very carefully whether the details are correct or not because these details are used in further process till getting your disability certificate and also these details are mentioned on disability certificate. If details are not correct visit to correction counter and correct it immediately after paying again same nominal fee.Visit concerned department related to your disability .You have to submit an application form alongwith affidavit mentioning the disability. You have to produce original aadhar card for identity verification.The application format are easily available nearby the Xerox shop.The list of enclosure attached with application are:1.Original Registration slip2.Aadhar card photocopy(or other acceptance document such as PAN card,voter id,mostly ask for Aadhar card)3.Two(2) passport size current photograph showing the disability (besides this 8 extra for application and affidavit purpose)4.Affidavit by district court mentioning the type of disability and stages of disability (by birth or hereditary or at some stages of life )In case of renewal of disability certificate, you must have to bring all old disability related documents and attached photocopy with this application.The board constitute of 3-5 members related to concerned disability. They examine the concerned disability and those disability which have an extent of more than or equal to 40% permanent disability are eligible for physical handicapped certificate for a period of 2or 5 years or life-long validity depending upon disability condition. In case of Temporary disability, handicapped certificate are also issue but not liable to any reservation benefits or other scheme .Only minimum 35% extent of disability required in case of mental retardation .In case of hearing problem or sometimes all types of disability,doctor always refer to AIIMS of that state or some other reputed medical science institute for examined with sound technology instrument.Visit the refered hospital or medical science institute and do registration process in concerned department and after appointment the doctor examined the case e.g. for hearing impairment case ENT Department refer to speech and audiological department for evaluation of hearing loss .Please confirm in case of hearing impairment from concerned hospital that how much minimum loss are eligible because on internet source it mentioned 60db loss from both ears but concerned hospital issue disability certificate from loss of 40db from both ears.After collecting report of concerned disability from refered medical institute again you have to visit Govt district hospital for getting disability certificate.Minimum duration from registration to getting physical handicapped certificate :1-2 monthsFor more details of specified disability you should download pdf and visit page no. 33 of “The Gazette of India extraordinary part-ll” dated 16.12.2016.Here are crop image of specified disability1.2.3.•Disability-Concerned doctor1.Multiple disabilities relating to orthopaedics, eye and ENT- Multi member board comprising specialist doctors pertaining to the concerned disabilities.2.Mental Retardation ,Neurological disorder,cerebral Palsy-Psychiatry, Neurology, Neurosurgery.3.Blindness-Eye Department4.Hearing Impairement-ENT department•Note:After getting disability certificate1.Apply immediately for travel concession certificate in same govt district hospital.2.Apply online for unique disability ID card for all future benefits.3.You may also visit AIIMS New Delhi for disability certificate according to your convenience.

What are some of the best ways to crack Foreign Medical Graduate Examination (FMGE)?

I have a pre-release copy of the ‘How to Crack FMGE’ pdf ebook. It is perhaps the best book I have in my arsenal for passing the FMGE, mostly because of the following:Other Indian prep books take material from USMLE or PLAB or OLD MCI syllabus, but this book has content that is designed from the bottom up - aimed at the new Indian NBE FMGE syllabus.Previous year questions are marked as footnotes which we can find together with highlighted clinical explanations.This is NOT another review book with just numbers and figures. It has well-written, but brief explanations. So that we understand the concept, easily memorize and also save a lot of time.Simplified diagrams, easy to learn algorithms and a list of resources after every chapter to learn more if you have trouble with the chapter.For example, my issue was with memorizing the pharmacology of Neurology drugs. The chapter on Neurology has an additional resources section which pointed me to the most insanely easy Neurology book on the planet: Neurology: A Visual ApproachYou can find books like the one above and free online resources after every page, so you can improve your weak topics.If you want the book, Send a request to the publisher using this form:How to Crack FMGE (Paperback/Ebook) Request Form

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