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PDF Editor FAQ

What is the mini mental state exam used for?

It's a screening test for dementia.Mini-mental state examination (MMSE) - Oxford Medical Education

Should someone see a neurologist if they suspect early stage Alzheimer's?

Neurologists are trained to detect subtleties of the brain that cause memory problems. Only they can conduct a thorough neurological exam and recommend subsequent treatment for brain disorders such as Alzheimer's. The Mini-Mental State Examination (MMSE) or Folstein test is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. It is commonly used in medicine and allied health to screen for dementia. Go to my Profile and you can find all about Alzheimer material there...

How does ADAS-Cog compare to ADCOMS as a clinical measure of Alzheimer's progression?

ADAS-Cog = Alzheimer's Disease Assessment Scale–cognitive subscaleADCOMS = Alzheimer’s Disease Composite ScoreADAS-Cog, along with the Mini-mental state exam (MMSE), Clinical Dementia Rating, and others, are examples of testing instruments used by clinicians. These are tests/questions/tasks administered to the patient by a trained clinical rater, and then an overall rating is determined.However, one issue with any single one of these instruments is that they are not always sensitive to the possibly subtle changes[1] that could occur in a broad array[2] of patients experiencing cognitive decline, especially at early stages of disease.Wang, et al[3] , present the ADCOMS composite score, which they developed by using “partial least squares regression with a longitudinal clinical decline model” to identify those items from commonly used clinical scales that showed the greatest sensitivity to declines in cognitive impairment.In short, ADCOMS is a composite measure, which, by design, is more sensitive to changes that occur in mild cognitive impairment than any single cognitive instrument. But this increased sensitivity has to be tested and quantified before this composite score can be used regularly.Footnotes[1] New scoring methodology improves the sensitivity of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in clinical trials.[2] Psychometric Properties of Alzheimer's Disease Assessment Scale-Cognitive Subscale for Mild Cognitive Impairment and Mild Alzheimer's Disease Patie... - PubMed - NCBI[3] Research paper: ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials

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