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Is it safe to take Metronidazole while breastfeeding?

It doesn’t seem to be a serious problem, although there was a little bit more Candida and diarrhea in the infant. From Metronidazole use while Breastfeeding | Drugs.com studying the effect of maternal metronidazole use on newborn infants found:Effects in Breastfed InfantsNone of ten 5-day-old infants who were breastfed every 4 hours after a single maternal 200 mg oral dose of metronidazole had any signs of oral or gastrointestinal upset during the 12-hour study period.[7]Sixteen newborn breastfed infants (aged 0 to 22 days) of mothers receiving 200 mg or 400 mg of oral metronidazole 3 times daily reportedly suffered no observable adverse reactions during the 9 days of the study.[10]A case of diarrhea and secondary lactose intolerance was possibly caused by metronidazole in breastmilk transmitted to the infant in the early neonatal period.[13]In a controlled, comparative study, 35 newborn infants were monitored for 10 days during maternal therapy with metronidazole and another antibiotic (33 ampicillin, 1 erythromycin and 1 cephalexin) for postpartum infection or prophylaxis. Dosages and routes of administration were not stated, but some mothers received the drugs intravenously initially and then were switched to oral therapy. Compared to infants of mothers who received ampicillin alone or no antibiotics, more infants exposed to metronidazole and ampicillin had very loose stools than in the other groups, especially when the drugs were given intravenously. More frequent and heavier growth of Candida species was found in the oral and perianal swabs of metronidazole-exposed infants, but this did not quite reach statistical significance (p=0.053). One infant exposed to metronidazole and ampicillin developed oral thrush. No differences were found between the groups in diaper rash, feeding problems or weight gain to the time of discharge.[11]

What are pros and cons of taking a course of fluconazole for candida?

The recommended dosage of DIFLUCAN for oropharyngeal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of oropharyngeal candidiasis generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse. Grapefruit juice slows down how quickly the body is able to break down the fluconazole, which could cause fluconazole levels in the blood to rise dangerously high. You should therefore avoid eating grapefruit and drinking grapefruit juice while taking fluconazole. Go to my Profile and you can find all yeast infection/candida material there...

What is the best medication for managing candidiasis?

There are 6 major presentations of yeast infections (Candidiasis). I summarized the treatment approach for each one of them.Treatment of Candida esophagitisIn simple cases nystatin is given as suspension, where 1 teaspoon contains 500,000 units, and this is administered four times daily for 7 to 14 days.However, in more severe cases the yeast bugs may be too deeply entrenched in the esophagus, so that the suspension cannot reach it. In these cases it needs to be coupled with oral medication such as ketoconazole or fluconazole. Alternatively amphotericin B, given intravenously, may have to be administered. The doctor may want to repeat the endoscopy procedure at the end of the treatment schedule to verify that the chronic esophagus yeast infection has indeed resolved.Treatment of yeast infections of the skinTopical nystatin or an azole (like clotrimazole, ketoconazole or fluconazole) is useful for many superficial skin infections. Onychomycosis is treated with oral fluconazole for several months. Many of these cases may require referral to a dermatologist.Genital yeast infection1.Treatment of vaginitisTreatment is similar as for yeast infections of the skin, except that nystatin is used in form of vaginal creams or vaginal inserts. If this does not lead to a successful cure, then clotrimazole ( brand name: Canesten) is used. Sometimes the vaginal yeast infection is difficult to control and an oral preparation of fluconazole (brand name: Diflucan) has to be used in a dosage of 100 to 200 mg daily for 1 or 2 weeks. The physician will want to keep an eye on liver function as some patients are more sensitive to this medication. However, this medicine has helped thousands of women with chronic recurrent yeast infections to achieve a lasting cure.2.Treatment of balanitisTreatment consists of topical creams or ointments and responds usually within two to three days. Nystatin, Canesten or Loprox cream are all effective. Rarely would there be a need for systemic antifungal tablets such as ketoconazole (brand name: Nizoral)or fluconazole(brand name: Diflucan)Treatment of oral CandidiasisNystatin is usually quite effective in these situations when given as oral solution. For more resistant cases the doctor may use fluconazole (brand name: Diflucan), although there can be some side effects such as liver toxicity and this would have to be monitored.Treatment of Candida meningitisThere is no standard regimen for Candida meningitis. Usually amphotericin B intravenously is the therapy of choice. Sometimes this has to be given through a catheter intrathecally (into the space where the cerebrospinal fluid is, so that the medication reaches higher concentrations in the meningeal area. Depending on the results of the culture and sensitivity testing this regimen may have to be combined with flucytosine, another antifungal medication. In AIDS patients there have been a number of cases where resistant yeast infections have been found and several newer antifungal medications in combination may have to be given by the physicianCandida sepsisIn a life threatening situation like this the physician will take all the necessary cultures (blood cultures and swabs) and send them to the lab. However, the physician will not wait for the results, but go with the clinical diagnosis and start intravenous therapy with amphotericin B, which is an antifungal antibiotic, right away. By the time the cultures come back the patient is usually much better and the physician can now decide whether to switch the medication to another antifungal therapy, based on culture and sensitivity results. High dose fluconazole therapy may have to be given and in some AIDS patients and other high-risk patients this may have to be continued on an ongoing basis as a maintenance therapy.More information about the myths of yeast infections here: Myths About Yeast Infections - Net Health Book

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