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PDF Editor FAQ

Decreasing the branched chain amino acids reduces obesity in mice. What is the likely effect in humans? How could we practically test a reduced BCAA diet?

You can’t reach strong conclusions from a single nutrition study, and the one in the link doesn’t report enough information to be confident about it’s conclusions.I recommend looking at literature reviews and meta analyses, like this one:http://ajcn.nutrition.org/content/early/2015/04/29/ajcn.114.084038.full.pdfIt concludes that…higher-protein diets that contain between 1.2 and 1.6 g protein /kg/d and potentially include meal-specific protein quantities of at least ~ 25–30 g protein/meal provide improvements in appetite, body weight management, cardiometabolic risk factors, or all of these health outcomes; however, further strategies to increase dietary compliance with long-term dietary interventions are warranted.But the authors also concluded that people have trouble sticking to such diets.Although greater satiety, weight loss, fat mass loss, and/or the preservation of lean mass are often observed with increased protein consumption in controlled feeding studies, the lack of dietary compliance with prescribed diets in free-living adults makes it challenging to confirm a sustained protein effect over the long term.Type of protein matters but it would be very difficult for people to get diets high or low in BCAA that doesn’t change lots of other things as well. It looks like red meat and processed meat pose greater risk of diabetes than other sources of protein (http://www.mdpi.com/2072-6643/9/9/982/pdf).The following is technical stuff about the study in the link. Non specialists can ignore it.The study described in the link doesn’t describe the diets in enough detail for me to tell what they did. The main report doesn’t describe the diets used for humans at all but references an appendix which doesn’t give much information either. My best guess is that their metabolic kitchen gave men foods to eat at home. These foods had differing amounts of protein. These men were asked to complete a daily meal checklist and this list was examined by someone at the laboratory.The authors apparently estimate energy intake using a four-day food diary and two using two different equations based on body size. They don’t explain how they combined those methods to get their overall estimates energy intakes. They also estimated protein, carbohydrate, and fat intake somehow; possibly based on the food diary.So, we don’t know exactly what these people were given and we can’t be sure that they ate what they were given (we know that self reports of food intake aren’t always accurate). This is their full description. Judge for yourself:Each participant randomized to the PR diet was fed customized isocaloric PR diets prepared by the Metabolic kitchen of the Washington University CARS. In the PR menus dietary protein intake was decreased to the Dietary Reference Intake (DRI) for total protein. For adult males the DRI is 56 grams per day. To provide the participants with isocaloric menus three calorie levels were available: 2300 calories, 2600 calories and 2900 calories. The menus were planned to provide a similar percent of calories from protein (8% to 9%) for the three calorie levels. The intakes of protein were 56 grams to 60 grams per day. Individualized energy intakes were estimated from a 4-day food diary and two formulas for estimating energy expenditure: Harris-Benedict equation and Cunningham equation (include body composition and physical activity factors). The PR participants received a calorie level that was estimated to maintain body weight. Compliance with the isocaloric lower protein diet for volunteers randomized to PR was assessed by means of the daily meal checklist.They also cite a clinical trial website which has no information about the diets: Does Protein Restriction Inhibit Prostrate Cancer Growth - Full Text View - ClinicalTrials.govThe diets did not manipulate BCAA separately from overall protein intake in humans, insofar as I can tell.

As a healthcare provider, what are some surprising disclosures you have encountered when reviewing a patient's "food diary"? Or as a patient keeping a "food diary," what would you probably not report that you had eaten?

Some decades ago, an anthropology Professor told our class about his surprise when his university couldn't reconcile a Native American man’s lab values and weight with his food diary and activity log. He was invited to stay for some period in the man's home, and he slept on the couch. He woke one night to find the man eating bear fat that he kept in his fridge. This explained the labs and weight, but the man explained that he never recorded that because he considered it “medicine, not food.”That story confirms that patients will often forget, or omit reporting the consumption of things that might interact with their meds, or impact their health, unless the questions are detailed enough and explained well. Healthcare providers are taught to ask for detailed histories of all “health foods,” “herbal remedies,” and “over the counter medicines and vitamins that they take, even if it's infrequently taken.There's another aspect to getting an accurate medical history: that patients honest answers are not only guided by the precision or ambiguity of the questions, but by their own definitions of those words. It is unwise to ask “do you drink alcohol” because the same patients who answer “no" will see no discrepancy in answering a later question about the frequency of alcohol consumption with “once a month.” A wise healthcare provider never asks “do you drink?” They start out with “do you drink 1 to 3 servings a week,” and narrow it down from there. You’ll never have a completely abstinent patient fail to make their drinking frequency clear, and you'll get more accurate estimates that way.

How often should you consume fast food?

According to a recent US study, you should eat fast food no more twice per week. The report of the link between fast food consumption and ill healthy shows that the more fast food consumed the greater a person's health risk.Most of time fast food is unhealthy with more fat, calories, sugar, sodium and less nutrition and vitamin than is necessary. Therefore, it is better if you cut down on some of the calories and extra fat in many fast food options. The following is some tips for break your fast food addiction:- Order smallest size: If cutting it out completely, it feels like a too big challenge for you; try reducing the size of your order. Remember that the larger sizes, the more fat, calories, sugar and sodium.- Pack food from home: If you’re going on a road trip, make sure you have healthy options ready. It available can help you fight off those convenience cravings.- Stop drinking soda: Try to avoid all kinds of soda. You should make a smarter choice and select skim or low-fat milk, fruit juice, diet soda or water.- Check the number of money you spend on fast food: If your healthy is not big motivator as much as you thought, estimate how much money you spend and how many calories you consume each week or month on fast food, it will shock you.- Make your own food diary: Record the type and amount of everything you eat and drink in as much detail as possible.Eating less fast food is good for your health, good for your waistline, good for your moods and even for your wallet. After the change, you will consider the value of smart choices for your health.

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