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Image source: fasting mimicking dietThe fasting mimicking diet (FMD) was at the center of this year’s anti-aging conference in Las Vegas. This was the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. Dr. Valter Longo, PhD reviewed some of the research he had done on longevity in yeast cells, worms and mice.Fasting mimicking diet relevant in humansDr. Longo pointed out that this type of research has relevance in humans. If there was a cure for cancer, heart disease, stroke and diabetes, we would live 13 years longer. But if we stimulated longevity with this pulsed calorie restricted diet, we would live on average 30 years longer. There is a rare genetic abnormality where people are deficient for IGF-1, a growth factor produced in the liver. These genetically IGF-1 deficient people live longer and do not develop cancer. Observations like these and detailed mouse experiments inspired Dr. Longo to develop a new diet plan. Patients would receive a fasting mimicking diet on 5 days per month. The rest of the month would consist of a normal, balanced diet. 5 days of the month the person would consume a low 600-800-calorie diet. This is enough to ensure adherence to the diet, but low enough to lead to enormous metabolic changes including youth-preserving stem cell stimulation.Clinical Application of fasting mimicking diet in cardiovascular healthDr. Joel Kahn, Prof. of Medicine at the Wayne State University School of Medicine lectured later that day. He is also the Director at the Kahn Center for Cardiac Longevity. His talk was entitled “The Fast Track to Slow Cardiac Aging: Fasting &Targeted Nutrition”. He mentioned that a fasting mimicking diet was a powerful tool in cardiology to prevent heart attacks and hardening of arteries. He explained in detail the complex aging pathways that involve three components, IGF-1, mTOR and PKA. When lifestyle choices stimulate these genetic markers, accelerated aging is a consequence. But with the inhibition of those markers longevity can happen. He added that researchers looked at heart cells, where the same principles apply. Dr. Kahn pointed out that the basic research of Dr. Longo enables clinicians to see positive results in patients who follow caloric restriction for 5 days in a month on a regular basis.How does the fasting mimicking diet work?It is best to let one of the users of this diet explain how it works. Once per month you eat calorie-restricted food with only 600-800 calories per day and you follow this regimen for 5 days. Some patients consume 1100 calories for the first of these 5 days, if they have difficulties switching from normal food to the boxed food. Dt. Longo has developed boxed food, called ProLon (from L-Nutra). ProLon stands for “pro longevity”. Dr. Longo and Dr. LaValle mentioned at the conference that these prepared meals make it a lot easier for patients to stick to the low calorie diet. Three hundred dollars for the boxed food for 5 days are a stiff price, and this may well be out of reach for you.Alternative way to make your own 600-800 calorie food at homeNevertheless, this should not stop you. You can look at the ingredients online and copy the boxed food by creating your own balanced 600-800 calories per day food at home. It is true: you have to do some research! But counting calories and finding information about the caloric content of food on the Internet is not difficult. And preparing these very, basic, small and simple meals does not require a degree in nutrition. Here is another testimony from a user of the fasting mimicking diet.Effect of the fasting mimicking diet on the metabolismIn the past it was thought that only ketogenic diets or periods of fasting would trigger longevity genes. But the basic research of Dr. Longo and others has shown that a low calorie diet for only 5 days can achieve the same thing. Longevity genes are activated; the negative aging pathways including IGF-1, mTOR and PKA are suppressed. The immune system gets activated from this. It also leads to lowering of LDL cholesterol, triglycerides, blood pressure, insulin resistance, and diabetes improves. With the fasting mimicking diet the stomach sees some food, but the cells are fasting. According to Dr. Kahn this combination down regulates the body’s key nutrient-sensing pathways, which activates cellular regeneration and rejuvenation.Clinical observationsDr. Khan observed a high compliance rate with 3 cycles of the fasting mimicking diet. 94% of a group of patients were compliant over 3 months. Mild fatigue, mild headaches and mild weakness were present, but improved with each cycle. In addition to the above findings Dr. Khan found that there was weight loss, abdominal fat loss and waist circumference loss. There was also a reduction in IGF-1 levels, a reduction of the C-reactive protein and stimulation of stem cells.Inflammation reduced, autoimmune diseases improvedThe reduction of the C-reactive protein proves that semi-fasting reduces inflammation. The finding of stimulation of stem cells explains that regenerative processes can take place. Pain disappears, people report more energy and are generally feeling better.There are other clinical findings. The positive effects from following the fasting mimicking diet last for several months. Also, when patients are on chemotherapy for cancer, the FMD will protect the healthy cells from the side effects of chemotherapy.Dr. Kahn and Dr. LaValle noted that autoimmune disease responded to FMD. This was shown in both animal experiments using mice and in clinical case reports. Dr. LaValle described a 46-year old former Olympic athlete swimmer who had multiple sclerosis. After FMD she lost all of her muscle aches and cured her optic neuritis. This was something conventional medicine could not do for her.Clinical applications of fasting mimicking dietHere are some of the conditions that will respond to it.Obesity, because of the weight loss effectDiabetes: insulin resistance becomes lower and blood sugar levels drop.High blood pressure reduced: many patients were able to reduce their medications or discontinue themPrevention of heart attacks and strokesPain conditions will improve as all kinds of pain disappears, an effect for which at this point is no explanationAutoimmune diseases like MS and rheumatoid arthritis improve, likely because of the effect of increased stem cell circulationPrevention of heart attacks because of reduction of LDL, triglycerides and CRPCancer cure rates improved by protecting normal cells and bone marrowLongevity improved in mice with a 3-fold increase of their life span. Telomere length in humans was increased. Increased stem cells will find defective areas that need repair. This effect will open up a new chapter in medicine.Maintaining the achievements of the fasting mimicking dietAt this point the implications of this new approach to weight loss and metabolic rejuvenation can only be estimated.Limiting calories for 5 days triggers a metabolic change, which is permanent. You can experience the full effect of this rejuvenating low calorie treatment. You can do it every month without having to fear vitamin or mineral deficiencies.Here is another link to the website of Dr. Axe where the fasting mimicking diet is also recommended.More info: fasting mimicking diet

It's only statistically improbable when you look at the results of all weight reduction programs.Break the studies down, though, and you see vastly different results.As Gary Taubes noted in "Good Calories, Bad Calories," meta-analysis of diet research shows that, in fact, calorie restriction fails. Or, more precisely, it works in approximately 1-2% of the population.That's because calorie restriction—another name for near-starvation diets—work against the body's push toward homeostasis. Your body will work against starvation by increasing appetite and decreasing energy expenditure. Eventually, you will give up and eat, and, most likely, overeat, to not only compensate but pack on more weight.Were you to look specifically at diet research studies that track the success of low-carbohydrate diets, you'd find that the success rate of long-term weight loss is about 50%.Clinicians report that those who fail at low-carbohydrate diets do so mostly because they can't accept, from a cognitive approach, going without the foods they love. Some refer to it simply as "bread addiction."Such an addiction is fueled by the vicious cycle of carbohydrates: eating high-carbohydrate food, particularly refined carbohydrates that are turned quickly into glucose, causes the pancreas to emit large quantities of insulin. Insulin spikes appetite, and thus sets up cravings for more carbohydrates. More carbohydrates are ingested, the pancrease is again stimulated to create more insulin, the insulin serves to store energy as body fat in the adipose tissue, and the body's muscles and organs are deprived of energy.This is called internal starvation. It's why obese people are always hungry. They're starving themselves by eating food that goes directly into fat storage and bypasses the organs and muscles.This is why Atkins involves a fast. It's one way to cut the vicious cycle. A fast is not the only way to do it. I started a low-carb diet about 3 years ago and found it satisfying enough that I didn't need to eat carbohydrate-rich food and therefore didn't need to inject the insulin a Type 1 diabetic such as myself has to take in to keep my blood sugar normalized.Others fail at low-carb diets because they lack knowledge of food preparation and analysis (i.e., looking at labels and looking up carbohydrate counts before eating something) and can't, or refuse, to learn these skills.My heart goes out to these people. It's difficult to convince them that the low-carb diet a satisfying diet that results in satiety. I was shocked myself to discover this.But clearly, the premise that an overweight person is statistically unlikely to lose weight is a simplification based on one particular form of diet.Don't try calorie restriction. You—or this 400-lb. theoretical man—will be bound to fail.Try carbohydrate restriction. Our theoretical 400-lb. man has a 50% chance of long-term weight loss. If he's dedicated to learning how to cook and how to analyze food choices, his chance at long-term weight loss approaches something quite a bit higher than 50%.

The fasting mimicking diet (FMD) was at the center of the anti-aging conference in Las Vegas. This was the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. Dr. Valter Longo, PhD reviewed some of the research he had done on longevity in yeast cells, worms and mice.Fasting mimicking diet relevant in humansDr. Longo pointed out that this type of research has relevance in humans. If there was a cure for cancer, heart disease, stroke and diabetes, we would live 13 years longer. But if we stimulated longevity with this pulsed calorie restricted diet, we would live on average 30 years longer. There is a rare genetic abnormality where people are deficient for IGF-1, a growth factor produced in the liver. These genetically IGF-1 deficient people live longer and do not develop cancer. Observations like these and detailed mouse experiments inspired Dr. Longo to develop a new diet plan. Patients would receive a fasting mimicking diet on 5 days per month. The rest of the month would consist of a normal, balanced diet. 5 days of the month the person would consume a low 800-calorie diet. This is enough to ensure adherence to the diet, but low enough to lead to enormous metabolic changes including youth-preserving stem cell stimulation.Clinical Application of fasting mimicking diet in cardiovascular healthDr. Joel Kahn, Prof. of Medicine at the Wayne State University School of Medicine lectured later that day. He is also the Director at the Kahn Center for Cardiac Longevity. His talk was entitled “The Fast Track to Slow Cardiac Aging: Fasting &Targeted Nutrition”. He mentioned that a fasting mimicking diet was a powerful tool in cardiology to prevent heart attacks and hardening of arteries. He explained in detail the complex aging pathways that involve three components, IGF-1, mTOR and PKA. When lifestyle choices stimulate these genetic markers, accelerated aging is a consequence. But with the inhibition of those markers longevity can happen. He added that researchers looked at heart cells, where the same principles apply. Dr. Kahn pointed out that the basic research of Dr. Longo enables clinicians to see positive results in patients who follow caloric restriction for 5 days in a month on a regular basis.How does the fasting mimicking diet work?It is best to let one of the users of this diet explain how it works. Once per month you eat calorie-restricted food with only 800 calories per day and you follow this regimen for 5 days. Some patients receive 1100 calories for the first of these 5 days, if they have difficulties switching from normal food to the boxed food. Dt. Longo has developed boxed food, called ProLon (from L-Nutra). ProLon stands for “pro longevity”. Dr. Longo and Dr. LaValle mentioned at the conference that these prepared meals make it a lot easier for patients to stick to the low calorie diet. Three hundred dollars for the boxed food for 5 days are a stiff price, and this may well be out of reach for you.Alternative way to make your own 800 calorie food at homeNevertheless, this should not stop you. You can look at the ingredients online and copy the boxed food by creating your own balanced 800 calories per day food at home. It is true: you have to do some research! But counting calories and finding information about the caloric content of food on the Internet is not difficult. And preparing these very, basic, small and simple meals does not require a degree in nutrition. Here is another testimony from a user of the fasting mimicking diet.Effect of the fasting mimicking diet on the metabolismIn the past it was thought that only ketogenic diets or periods of fasting would trigger longevity genes. But the basic research of Dr. Longo and others has shown that a low calorie diet for only 5 days can achieve the same thing. Longevity genes are activated; the negative aging pathways including IGF-1, mTOR and PKA are suppressed. The immune system gets activated from this. It also leads to lowering of LDL cholesterol, triglycerides, blood pressure, insulin resistance, and diabetes improves. With the fasting mimicking diet the stomach sees some food, but the cells are fasting. According to Dr. Kahn this combination down regulates the body’s key nutrient-sensing pathways, which activates cellular regeneration and rejuvenation.Clinical observationsDr. Khan observed a high compliance rate with 3 cycles of the fasting mimicking diet. 94% of a group of patients were compliant over 3 months. Mild fatigue, mild headaches and mild weakness were present, but improved with each cycle. In addition to the above findings Dr. Khan found that there was weight loss, abdominal fat loss and waist circumference loss. There was also a reduction in IGF-1 levels, a reduction of the C-reactive protein and stimulation of stem cells.Inflammation reduced, autoimmune diseases improvedThe reduction of the C-reactive protein proves that semi-fasting reduces inflammation. The finding of stimulation of stem cells explains that regenerative processes can take place. Pain disappears, people report more energy and are generally feeling better.There are other clinical findings. The positive effects from following the fasting mimicking diet last for several months. Also, when patients are on chemotherapy for cancer, the FMD will protect the healthy cells from the side effects of chemotherapy.Dr. Kahn and Dr. LaValle noted that autoimmune disease responded to FMD. This was shown in both animal experiments using mice and in clinical case reports. Dr. LaValle described a 46-year old former Olympic athlete swimmer who had multiple sclerosis. After FMD she lost all of her muscle aches and cured her optic neuritis. This was something conventional medicine could not do for her.Clinical applications of fasting mimicking dietHere are some of the conditions that will respond to it.Obesity, because of the weight loss effectDiabetes: insulin resistance becomes lower and blood sugar levels drop.High blood pressure reduced: many patients were able to reduce their medications or discontinue themPrevention of heart attacks and strokesPain conditions will improve as all kinds of pain disappears, an effect for which at this point is no explanationAutoimmune diseases like MS and rheumatoid arthritis improve, likely because of the effect of increased stem cell circulationPrevention of heart attacks because of reduction of LDL, triglycerides and CRPCancer cure rates improved by protecting normal cells and bone marrowLongevity improved in mice with a 3-fold increase of their life span. Telomere length in humans was increased. Increased stem cells will find defective areas that need repair. This effect will open up a new chapter in medicine.Maintaining the achievements of the fasting mimicking dietAt this point the implications of this new approach to weight loss and metabolic rejuvenation can only be estimated.Limiting calories for 5 days triggers a metabolic change, which is permanent. You can experience the full effect of this rejuvenating low calorie treatment. You can do it every month without having to fear vitamin or mineral deficiencies.Here is another link to the website of Dr. Axe where the fasting mimicking diet is also recommended.To answer your question: What are your thoughts on the Fasting Mimicking Diet? I was so impressed by all of the talks at the 25th Anti-aging conference in Las Vegas about FMD that I started doing it myself. I just completed the second course of 5 days every month. What impressed my most is that animal experiments and humans studies showed both that stem cells are released and circulate more and that the telomeres (the ends of chromosomes in the cell nucleus) are being elongated. Both of these effects mean a healthier and longer life. I find that 600 to 800 calories daily during the 5 days of a fasting mimicking diet are doable. A water fast is not doable for me.More info: http://www.askdrray.com/fasting-mimicking-diet/