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This is SUCH a loaded question.It really depends on the product. The thing they don’t tell you in the ads is that every product is not going to be what every person needs. It’s just like Slim Fast shakes. Do they really work? Probably for 5% of the people who use them but the company will keep convincing people to try it and take their money. Is it healthy or safe? Well it’s probably not UNhealthy enough for the FDA to take it off the market, which doesn’t say much for the product (or the FDA really).Do you want great health?get plenty of sun to boost your vitamin D and prevent Seasonal Affective Disordereat clean food and eat for your metabolic type (check out a free metabolic typing test online {Natural Health Information Articles and Health Newsletter by Dr. Joseph Mercola has one} and Whole30 for ways of clean eating that can be customized so that they are good for everyone)drink half your body weight in pure, clean water every single day (not tea, not coffee, WATER)Move your butt. Walk with your legs, do some light strength training, don’t do too much cardio.Do take a broad spectrum enzyme and good food-based multivitamin every dayIf you do all of that every day you will feel better guaranteed. If you can drop sugar and packaged foods as well then you will do even BETTER. You won’t need bee propolis or coQ-10 (well, that’s sort of a good one if you’re elderly unless you like eating beef hearts, especially if you ever let a doctor convince you to take statins).If water tastes bad to you then try another water. I filter with a Berkey at home and buy Evian, Fiji, or Fox Ledge when I’m out and about because I’m a water snob. It’s okay to be a water and food snob. Quality counts and so does your health.Like I mentioned before, though, supplements have their place. Mostly they take the place of healthy habits for a chronically sick population. People would rather pop a pill than drink a glass of water or eat enough vegetables. Some of us also have genetic defects that make us deficient in certain nutrients. I have MTHFR, for example, so I have to take a special pre-digested form of folate to prevent issues.Or our bodies are so badly abused by poor quality foods or improper eating habits that we don’t make enough enzymes to digest our food and it leads to digestive disorders like IBS or systemic candida which is why you should take enzymes with every meal. Not the crappy cheap ones. Spend a little money if you can to get the good enzymes. I personally like Klaire Labs Vital-Zymes because they’re inexpensive but good quality. Don’t cheap out on multi-vitamins, either. Make sure to buy multi-vitamins that are food based and make sure they don’t contain synthetic vitamins. What vitamins are synthetic? D2, folic acid, and others. Do a little research and make sure your vitamins have D3 and folate at the very least. Garden of Life or New Chapter Organics are great brands to look into. Our food is too nutritionally depleted for even a person with a 100% perfect diet to get the nutrients they need every day, much less a person who might eat processed food.BTW, that B12 and vitamin D your doctor told you to take? Sounds like you need more sun exposure and a better diet. Don’t supplement vitamin D without also adding K2 or you’ll calcify your kidneys. And B12 shouldn’t be taken by itself so try to get a multivitamin with B12 or a B complex with all the B’s in it.I’ll tell you a secret: doctors are not experts on supplements and how to use them. They are taught mostly to use pharmaceutical drugs and their nutritional knowledge is also sorely lacking. The average MD has less than 25 credit hours in nutrition, and that knowledge is usually your standard USDA knowledge that has been bought and paid for by the various Washington lobbies.This means you need to go to someone who knows good nutrition and knows what supplements can do. Ideally you should be on as few as possible BUT sometimes to heal your body you temporarily need to take more. If someone recommends you add supplementation for more than 6–12 months without a chronic or genetic disorder then go to someone else. The only supplements you should take every day is the multi vitamin and multi enzyme. That’s IT. Good luck.