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Does transcranial magnetic stimulation really work?

rTMS works extraordinarily well. Almost any brain disease except seizures, infection and neoplasms. Full remission (no symptoms) 35–50%, Response (50% or greater symptom reduction) 35–50% and failure in 10–15%.If you are not getting results, check if the machine is working, get a better device (MagStim and MagPro are the best, sell your NeuroStar and BrainSway- they belong in museums). Measure 6–8 cm anterior of motor cortex NOT 5cm - otherwise you are stimulating FEF (Brodmanns area 8) or Broca’s Area (BA44/45). Read Fitzgerald et al for details. Use the Beam protocol for locating DLPFC, all you need is a tape measure and Internet access.Many conditions and Comorbidity combinations benefit dramatically from rTMS (and Theta Burst Stimulation). Depression, bipolar, anxiety, chronic pain, ADHD, Dementia, PTSD, autism head trauma, Parkinsons Disease (idiopathic paralysis agitans) and many more respond quickly and permanently.The APA lists TMS as an option if even one medication is not successful. In the STAR*D trial, patients who did not have a response to 3 prior medications had a 6.5 % likelihood of responding to the 4th. THESE SAME PATIENTS have a 37–48% likelihood of responding to TMS.One could argue, that offering a 4th medication without discussing the option of TMS is unethical.Because many patients do not want to take medications at all, there may be a future for first line TMS treatment.a few Meta-analyses of TMS for Depression:Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data.Brunoni AR1, Moffa AH2, Fregni F2, Palm U2, Padberg F2, Blumberger DM2, Daskalakis ZJ2, Bennabi D2, Haffen E2, Alonzo A2, Loo CK2.Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity. AIMS: To assess tDCS efficacy and to explore individual response predictors. METHOD: Systematic review and individual patient data meta-analysis. RESULTS: Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38-4.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7% respectively, OR = 2.38, 95% CI 1.22-4.64, NNT = 9) and depression improvement (B coefficient 0.35, 95% CI 0.12-0.57). Mixed-effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS 'doses' were, respectively, negatively and positively associated with tDCS efficacy. CONCLUSIONS: The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose.Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.To date, several randomized controlled trials (RCTs) have shown the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depression. OBJECTIVE: This analysis examined the antidepressant efficacy of rTMS in patients with treatment-resistant unipolar depression. METHODS: A literature search was performed for RCTs published from January 1, 1994, to November 20, 2014. The search was updated on March 1, 2015. Two independent reviewers evaluated the abstracts for inclusion, reviewed full texts of eligible studies, and abstracted data. Meta-analyses were conducted to obtain summary estimates. The primary outcome was changes in depression scores measured by the Hamilton Rating Scale for Depression (HRSD), and we considered, a priori, the mean difference of 3.5 points to be a clinically important treatment effect. Remission and response to the treatment were secondary outcomes, and we calculated number needed to treat on the basis of these outcomes. We examined the possibility of publication bias by constructing funnel plots and by Begg's and Egger's tests. A meta-regression was undertaken to examine the effect of specific rTMS technical parameters on the treatment effects. RESULTS: Twenty-three RCTs compared rTMS with sham, and six RCTs compared rTMS with electroconvulsive therapy (ECT). Trials of rTMS versus sham showed a statistically significant improvement in depression scores with rTMS (weighted mean difference [WMD] 2.31, 95% CI 1.19-3.43; P < .001). This improvement was smaller than the pre-specified clinically important treatment effect. There was a 10% absolute difference between rTMS and sham in the rates of remission or response. This translates to a number needed to treat of 10. Risk ratios for remission and response were 2.20 (95% CI 1.44-3.38, P = .001 and 1.72 [95% CI], 1.13-2.62, P = .01), respectively, favouring rTMS. No publication bias was detected. Trials of rTMS versus ECT showed a statistically and clinically significant difference between rTMS and ECT in favour of ECT (WMD 5.97, 95% CI 0.94-11.0, P = .02). Risk ratios for remission and response were 1.44 (95% CI 0.64-3.23, P = .38) and 1.72 (95% CI 0.95-3.11, P = .07), respectively, favouring ECT. CONCLUSIONS: Overall, the body of evidence favoured ECT for treatment of patients who are treatment-resistant. Repetitive transcranial magnetic stimulation had a small short-term effect for improving depression in comparison with sham, but follow-up studies did not show that the small effect will continue for longer periods.Deep transcranial magnetic stimulation (DTMS) in the treatment of major depression: An exploratory systematic review and meta-analysis.Kedzior KK1, Gellersen HM2, Brachetti AK2, Berlim MTDeep transcranial magnetic stimulation (DTMS) is a relatively new, non-invasive method of stimulating larger and, presumably, deeper brain regions. The current study investigated if DTMS delivered with H-coils has acute antidepressant effects in major depression using a systematic literature review and a quantitative meta-analysis. METHODS: Seventeen studies on 'DTMS or H-coil' and 'depression' were identified on Medline, PsycInfo, and Google Scholar (until November 2014). Data from nine open-label studies were meta-analysed using a random-effects model with inverse-variance weights. The outcome measures were the standardised paired mean difference (Cohen's d) in depression scores on Hamilton Depression Rating Scale (HDRS), response, remission, and dropout rates after acute DTMS treatment compared to baseline. RESULTS: There was a large antidepressant effect after 20 acute, high-frequency DTMS sessions compared to baseline according to HDRS change scores (overall mean weighted d=2.04, 95% confidence interval: 1.53-2.55; nine studies; 150 patients). Overall weighted response, remission, and dropout rates were 60%, 29%, and 18% respectively. HDRS change scores and response rates tended to be higher in four studies with 68 patients on concurrent antidepressants compared to two studies with 26 patients who received DTMS as a monotherapy. LIMITATIONS: These results are based on data from a low number of open-label studies. CONCLUSION: High-frequency DTMS appears to have acute antidepressant effects after 20 sessions in mostly unipolar and treatment-resistant patients. Concurrent treatment with antidepressants might enhance the efficacy of DTMS.Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression in Adult and Youth Populations: A Systematic Literature Review and Meta-Analysis.Leggett LE1, Soril LJ1, Coward S1, Lorenzetti DL2, MacKean G1, Clement FM1.Between 30% and 60% of individuals with major depressive disorder will have treatment-resistant depression (TRD): depression that does not subside with pharmaceutical treatment. Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for TRD. OBJECTIVE: To establish the efficacy and optimal protocol for rTMS among adults and youth with TRD. DATA SOURCES: Two systematic reviews were conducted: one to determine the efficacy of rTMS for adults with TRD and another to determine the effectiveness of rTMS for youth with TRD. For adults, MEDLINE, Cochrane Central Register of Controlled Trials, PubMed, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, and Health Technology Assessment Database were searched from inception until January 10, 2014 with no language restrictions. Terms aimed at capturing the target diagnosis, such as depression and depressive disorder, were combined with terms describing the technology, such as transcranial magnetic stimulation and rTMS. Results were limited to studies involving human participants and designed as a randomized controlled trial. For youth, the search was altered to include youth only (aged 13-25 years) and all study designs. When possible, meta-analysis of response and remission rates was conducted. STUDY SELECTION: Seventy-three articles were included in this review: 70 on adult and 3 on youth populations. RESULTS: Meta-analysis comparing rTMS and sham in adults found statistically significant results favoring rTMS for response (RR: 2.35 [95% CI, 1.70-3.25]) and remission (RR: 2.24 [95% CI, 1.53-3.27]). No statistically significant differences were found when comparing high- and low-frequency, unilateral and bilateral, low- and high-intensity rTMS or rTMS and electroconvulsive therapy (ECT). While meta-analysis of results from the youth literature was not possible, the limited evidence base suggests that rTMS may be effective for treating TRD in youth. CONCLUSIONS: The evidence available on the use of rTMS for adults with TRD indicates that rTMS is approximately twice as effective as a sham procedure, although the optimal rTMS protocol remains unclear. Evidence also indicates that rTMS is as effective as ECT and appears promising as a treatment for youth with TRD; however, the evidence base is underdeveloped.Short-term efficacy of repetitive transcranial magnetic stimulation (rTMS) in depression- reanalysis of data from meta-analyses up to 2010.Kedzior KK1, Reitz SK1.According to a narrative review of 13 meta-analyses (published up to 2010), repetitive transcranial magnetic stimulation (rTMS) has a moderate, short-term antidepressant effect in the treatment of major depression. The aim of the current study was to reanalyse the data from these 13 meta-analyses with a uniform meta-analytical procedure and to investigate predictors of such an antidepressant response. METHODS: A total of 40 double-blind, randomised, sham-controlled trials with parallel designs, utilising rTMS of the dorsolateral prefrontal cortex in the treatment of major depression, was included in the current meta-analysis. The studies were conducted in 15 countries on 1583 patients and published between 1997-2008. Depression severity was measured using the Hamilton Depression Rating Scale, Beck Depression Inventory, or Montgomery Åsberg Depression Rating Scale at baseline and after the last rTMS. A random-effects model with the inverse-variance weights was used to compute the overall mean weighted effect size, Cohen's d. RESULTS: There was a significant and moderate reduction in depression scores from baseline to final, favouring rTMS over sham (overall d = -.54, 95% CI: -.68, -.41, N = 40 studies). Predictors of such a response were investigated in the largest group of studies (N = 32) with high-frequency (>1 Hz) left (HFL) rTMS. The antidepressant effect of HFL rTMS was present univariately in studies with patients receiving antidepressants (at stable doses or started concurrently with rTMS), with treatment-resistance, and with unipolar (or bipolar) depression without psychotic features. Univariate meta-regressions showed that depression scores were significantly lower after HFL rTMS in studies with higher proportion of female patients. There was little evidence for publication bias in the current analysis. CONCLUSIONS: Daily rTMS (with any parameters) has a moderate, short-term antidepressant effect in studies published up to 2008. The clinical efficacy of HFL rTMS may be better in female patients not controlling for any other study parameters.Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis.Gaynes BN1, Lloyd SW, Lux L, Gartlehner G, Hansen RA, Brode S, Jonas DE, Swinson Evans T, Viswanathan M, Lohr KN.To evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with major depressive disorder (MDD) and 2 or more prior antidepressant treatment failures (often referred to as treatment-resistant depression [TRD]). These patients are less likely to recover with medications alone and often consider nonpharmacologic treatments such as rTMS. DATA SOURCES: We searched MEDLINE, EMBASE, the Cochrane Library, PsycINFO, and the International Pharmaceutical Abstracts for studies comparing rTMS with a sham-controlled treatment in TRD patients ages 18 years or older. STUDY SELECTION: We included 18 good- or fair-quality TRD studies published from January 1, 1980, through March 20, 2013. DATA EXTRACTION: We abstracted relevant data, assessed each study's internal validity, and graded strength of evidence for change in depressive severity, response rates, and remission rates. RESULTS: rTMS was beneficial compared with sham for all outcomes. rTMS produced a greater decrease in depressive severity (high strength of evidence), averaging a clinically meaningful decrease on the Hamilton Depression Rating Scale (HDRS) of more than 4 points compared with sham (mean decrease = -4.53; 95% CI, -6.11 to -2.96). rTMS resulted in greater response rates (high strength of evidence); those receiving rTMS were more than 3 times as likely to respond as patients receiving sham (relative risk = 3.38; 95% CI, 2.24 to 5.10). Finally, rTMS was more likely to produce remission (moderate strength of evidence); patients receiving rTMS were more than 5 times as likely to achieve remission as those receiving sham (relative risk = 5.07; 95% CI, 2.50 to 10.30). Limited evidence and variable treatment parameters prevented conclusions about which specific treatment options are more effective than others. How long these benefits persist remains unclear. CONCLUSIONS: For MDD patients with 2 or more antidepressant treatment failures, rTMS is a reasonable, effective consideration.Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials.Berlim MT1, van den Eynde F1, Tovar-Perdomo S1, Daskalakis ZJ2.Meta-analyses have shown that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has antidepressant properties when compared with sham rTMS. However, its overall response and remission rates in major depression (MD) remain unclear. Thus, we have systematically and quantitatively assessed the efficacy of HF-rTMS for MD based on randomized, double-blind and sham-controlled trials (RCTs). METHOD: We searched the literature from 1995 through to July 2012 using MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, SCOPUS, and ProQuest Dissertations & Theses. We used a random-effects model, odds ratios (ORs) and the number needed to treat (NNT). RESULTS: Data from 29 RCTs were included, totaling 1371 subjects with MD. Following approximately 13 sessions, 29.3% and 18.6% of subjects receiving HF-rTMS were classified as responders and remitters, respectively (compared with 10.4% and 5% of those receiving sham rTMS). The pooled OR was 3.3 (p < 0.0001) for both response and remission rates (with associated NNTs of 6 and 8, respectively). Furthermore, we found HF-rTMS to be equally effective as an augmentation strategy or as a monotherapy for MD, and when used in samples with primary unipolar MD or in mixed samples with unipolar and bipolar MD. Also, alternative stimulation parameters were not associated with differential efficacy estimates. Moreover, baseline depression severity and drop-out rates at study end were comparable between the HF-rTMS and sham rTMS groups. Finally, heterogeneity between the included RCTs was not statistically significant. CONCLUSIONS: HF-rTMS seems to be associated with clinically relevant antidepressant effects and with a benign tolerability profile.Repetitive transcranial magnetic stimulation (rTMS) for treating major depression and schizophrenia: a systematic review of recent meta-analyses.Hovington CL1, McGirr A, Lepage M, Berlim MT.In recent years, repetitive transcranial magnetic stimulation (rTMS) has been developed for the treatment of major depression (MD) and schizophrenia. Although rTMS has shown some promising findings, the lack of standardization in the methodology employed has resulted in discordant findings. OBJECTIVES: The objective of this systematic review was to summarize several meta-analytical studies exploring the efficacy of rTMS in either MD or schizophrenia in order to examine the methodologies that increase the efficacy of rTMS and to provide some recommendations for future studies. METHODS: We searched the MEDLINE database for potentially relevant meta-analytic studies on the use of rTMS for treating major depression and schizophrenia published from January 2000 to October 2011. RESULTS: Fifteen rTMS meta-analytical studies were reviewed (11 on MD and 5 on schizophrenia). Several variables were reviewed including outcome measures, side-effects of rTMS, site of stimulation, frequency and intensity of stimulation, and number of treatment sessions. CONCLUSIONS: Overall, rTMS appears to be an effective and promising therapeutic for both MD and schizophrenia.Has repetitive transcranial magnetic stimulation (rTMS) treatment for depression improved? A systematic review and meta-analysis comparing the recent vs. the earlier rTMS studies.Gross M1, Nakamura L, Pascual-Leone A, Fregni F.To investigate whether the recent repetitive transcranial magnetic stimulation (rTMS) studies on depression using new parameters of stimulation have shown improved clinical results. METHOD: We performed a systematic review and a meta-analysis of the rTMS studies on depression published in the past 12 months comparing these results with an earlier meta-analysis that analyzed the results of the initial rTMS studies on depression. RESULTS: Using our inclusion criteria, we selected the meta-analysis of Martin [Br J Psychiatry (2003) Vol. 182, 480-491] that included 13 studies (324 patients) and five studies for the recent meta-analysis (274 patients). The pooled effect size (standardized mean difference between pretreatment vs. post-treatment) from the random effects model was -0.76 (95% confidence interval, CI, -1.01 to -0.51). This result was significantly larger than that of the earlier meta-analysis (-0.35, 95% CI -0.66 to -0.04). CONCLUSION: Our findings suggest that recent rTMS clinical trials have shown larger antidepressant effects when compared with the earlier studies.Efficacy of rapid-rate repetitive transcranial magnetic stimulation in the treatment of depression: a systematic review and meta-analysis.Couturier JL1.To systematically review the literature pertaining to rapid-rate repetitive transcranial magnetic stimulation (rTMS) compared with sham therapy for the treatment of a major depressive episode in order to arrive at qualitative and quantitative conclusions about the efficacy of rapid-rate rTMS. METHODS: MEDLINE, the Cochrane Library, the metaRegister of Controlled Trials and abstracts from scientific meetings were searched for the years 1966 until July 2003. The search terms "transcranial magnetic stimulation" and "transcranial magnetic stimulation AND depression" were used. Eighty-seven randomized controlled trials investigating the efficacy of rTMS were referenced on MEDLINE. Nineteen of these involved treatment of a major depressive episode, and these were reviewed. Six met more specific inclusion criteria including the use of rapid-rate stimulation, application to the left dorsolateral prefrontal cortex, evaluation with the 21-item Hamilton Rating Scale for Depression (HAM-D) and use of an intent-to-treat analysis. Scores on the 21-item HAM-D after treatment and standard deviations were extracted from each article for treatment and control subjects. A random-effects model was chosen for the meta-analysis, and the weighted mean difference was used as a summary measure. RESULTS: Six studies that met the inclusion criteria were identified and included in the meta-analysis. Two of these reported a significantly greater improvement in mood symptoms in the treatment versus the sham group. When combined in the meta-analysis, the overall weighted mean difference was -1.1 (95% confidence interval -4.5 to 2.3), and the results of a test for heterogeneity were not significant (chi2(5) = 5.81, p = 0.33). CONCLUSIONS: This meta-analysis suggests that rapid-rate rTMS is no different from sham treatment in major depression; however, the power within these studies to detect a difference was generally low. Randomized controlled trials with sufficient power to detect a clinically meaningful difference are required.

Is the copper in a "wheat" penny worth more than a penny?

“Is the copper in a "wheat" penny worth more than a penny?”There might be some confusion here regarding exactly what is being discussed, so I will start with a little bit of background information.Ever since 1864, all the way up to 1982 (with the notable exception of 1943, when they were made from 100% steel), the one-cent coin commonly known as the “penny” has contained 95% copper. The remaining 5% has varied over time from pure tin, to various tin/zinc alloys, to pure zinc.In 1982, the composition of the penny was changed to a pure zinc core comprising 97.5% of the total weight of the coin, plated with pure copper which makes up the remaining 2.5% of the total coin weight.This change in composition is why post-1982 pennies weigh 2.5 grams, which is 0.61 grams lighter than the older composition of 3.11 grams. (1982 pennies were made in both compositions). This explains composition, and now I will explain design.1900 Indian Head cent. Image from Coinancials.Back in 1864, the cent in usage was the one that is today known as the “Indian Head” penny, which featured the Spirit of Liberty wearing a feathered headdress on the obverse (front) and an oak wreath and shield on the reverse; this design remained in use up until 1908, to be replaced in 1909 (to celebrate the 100th birthday of Lincoln)with the still-current Lincoln head, but featuring a wreath made from two sheaves of wheat on the reverse. This is what we call the “wheat penny”.1909S Lincoln Wheat Cent. Image from US Coin Guide.In 1959, the US Mint decided to celebrate the 150th birthday of Lincoln by changing the reverse to an image of the Lincoln Memorial. As mentioned earlier, This type of penny was produced in both bronze (95% copper) and zinc (97.5% zinc) compositions.1979 Lincoln Memorial Cent (copper). Image from The Spruce Crafts.2000 Lincoln Memorial Cent (zinc). Image from USA Coin Book.In 2009, to celebrate the 200th anniversary of Lincoln's birth, the US mint issued four alternate reverses illustrating different stages in Lincoln's life; the log cabin of his youth in Kentucky, his formative years in Indiana showing Lincoln resting after chopping wood, Lincoln standing in front of the Illinois State Capitol, and his presidency in Washington DC, represented by the half-completed Capitol dome.2009 Lincoln Bicentennial Cents (zinc). Image from The Spruce Crafts.In 2010, the reverse was again changed, this time to that of the US Union Shield, to represent mutual defense and the will to preserve the Union.2010 Lincoln Shield Cent. Image from USA Coin Book.All indian head cents, wheat cents, and memorial cents up until 1981 (and about half of those dated 1982) have exactly the same value in copper, which in today's market (as I write this in mid-April, 2019) is approximately 1.9¢.This value is the same whether the coin is a wheatie or a pre-1982 memorial so, to answer the question as written, the copper in a wheat penny is not worth more than the copper in other copper penny types.That being said, the total value of a zinc cent is 0.77¢ (less than 8/10 of one cent), of which less than one tenth of it is the copper value, the main worth being its zinc content.Thanks for the A2A!Edited for minor typo corrections.

Is Andhra Pradesh developing under Chandrababu Naidu?

Updated the Answer and added few additional things that has happen in last two years too.The answer is a big Yes, Most of the people who answered here are either not residing in Andhra Pradesh or they aren’t aware of things happening in AP. Bare with me as it is a pretty big answer included what CBN has done in the past 5 years.This time CBN became CM for a state that doesn’t have a capital and with a government deficit of about 17k Crores.He has been converting crisis into an opportunity from Day 1 let me make you to go through the things happened in the state after he taking charge as CM in 2014.HUDHUD in 2014After he took charge in 2014 HUDHUD was an uninvited guest it was the biggest cyclone in Vizag’s history as a Viziagite i knew it personally, my parents witnessed it. When HudHud hit Vizag I’m in Hyderabad, When things restored i called my mother and she said how harsh mother nature was. AP under the leadership of CBN is completely prepared and CBN brought normalcy in a week. He brought most of the government employees to Vizag and made them work to get things under control. In our area power was restored in 3 days, in Villages it took 5–6 days. He is the first one to reach Vizag after HUDHUD hit Vizag, he worked in a bus and brought things under control. He gave stern warnings to telecom operators and made them to restore their networks ASAP.After 3 years recently this happened, Kudos to GVMC and AP Government.VizagHe is trying hard to make Vizag an IT Hub. The construction of Millennium Tower was completed a few months back and Conduent has started operations in it. They have even started Construction of Tower 2 next to it. There is even a lot of Pitching going on for promoting Vizag as a Fintech Destoination. Roadshows conducted in Hongkong, Bangalore, London, Tel Aviv, New York City and many other cities across the globe. To know more about it follow their twitter handle here[1]TU-142 is brought to Vizag and that is being made as a museum, there are even plans of bringing INS Viraat to Vizag the talks are still happening. New Glass domed train to ArakuGVMC will be the first Municipal Corporation in India to deploy a 100 mass electric two-wheeler mobility system. GVMC sanitary supervisors will be using these for their daily patrol and supervision.AP Med Tech Zone, VizagAdani group has come forward to invest 70,000 Crores in coming 20 years, They will setup three 1 Giga Watt Data centers in Kapuluppada Data Center park.Rise of AmaravatiAccording to me, Amaravati is the right place to be chosen as a capital it has got both the historical significance and the needed resources to be the futuristic capital of AP. Amaravati, a place with great heritage running back over 2000 years. Nowhere in Independent India, 30,000 acres of land is pooled voluntarily, it’s CBN’s innovative idea of land pooling that’s a win-win for both the government and farmers. Many states today are adopting CBN’s land pooling scheme for developmental activities in their states. Made Singapore Government prepare the master plan for Amaravati for free of cost.Appointed Fosters + Partners [2]as the architects for the government complex. Here is the master plan that was recently submitted to Government of Andhra Pradesh by Foster + Partners. By looking at it I am sure and confident that Amaravati will be India's and one of the world's best city. Brace yourself Chandigarh we are going to steal best city tag from you in two decades. This is the final design of our assembly building that is going to come up at our World class Amaravati.For closely working with people of AP he wanted to shift from Hyderabad, Within 197 days he is able to do this in AmaravatiTemporary High Court Secretariat and Assembly are up and now functioning, Seed Axis roadworks are happening in full Swing. VIT, SRM started constructing their campuses in Amaravati. AIIMS construction started in Amaravati.Singapore Government and AP Government signed an MOU recently. Singapore Government Consortium will develop a 6.58 Km of startup area which will be almost 16 times bigger and better than the Raheja Mind space in Hyderabad which was built when he was the erstwhile CM of AP.Vijayawada got it’s brand new Airport terminal in less than a yearCurrent status of AmaravatiMost of my friends feel that Amaravati is going at a slower pace, But according to me, it’s not, the reasons are In a country like India pooling 34000 acres of land in a year is itself an achievement thanks to CBN’s innovative land pooling idea. If you can check the status of land acquisition of some other projects like Navi Mumbai airport and even Modi’s Pet Project(Bullet train) land acquisition has become a big problem.And also people don’t realize the amount of effort that is being put for the trunk infrastructure like sewage, Electricity, fresh water supply, and other works as they are done underground and are not visible.Majority of Government Employees housing projects are in the final stages. Construction of Government complex towers has been started and are in full swing. A total of about 40,000 Crore works are being done in Amaravati.Check this Video for the status of Amaravati here[3] .Uplifting RayalaseemaRayalaseema getting most of the investments is a sign that CBN wants to lift people of Seema from factionism.Rayalaseema gets MI, Dixon, TCL, Zoho Hero, KIA, Apollo tyres, ISUZU, Mega Seeds Factory, Oravakallu Airport, Jairaj Steel plant and Kurnool Solar Plant.Do you know that Kochi Metro and Sydney Metro Coaches are Made in Andhra at our Alstom Facility in Sri City.Here is a video of Chittoor MI plant, the MI phone in your hand is Made in Andhra Pradesh.India’s biggest FDI after Modi announcing #MakeInIndia Kia Motors India entry to Anathapuram, AP. A Huge sum of 2 billion USD investment.When I have written this answer couple of years back the MoU was signed but today the plant is up and it has changed the face of Penukonda region. Kia’s first car will be out anytime soon. To know more check this out[4]The most important thing is People of Seema got water through Pattiseema.Power Reforms and Renewable EnergyAP started its account as a power deficit state, CBN mobilized and managed to enter Centers power for all scheme and today AP is power surplus state. AP added almost 4000mw of renewable power capacity to its grid after CBN taking charge. Today AP is 100% electrified state after TN and Gujarat. AP distribution losses are the lowest in the country.AP is the top 3 in the distribution of LED bulbs you can check that here[5]You can track power cuts, Power supply to your city and towns in AP here[6]One of world’s Largest Solar Park in AP in Kurnool 1000mw, This is bigger than the one in TN built by Adani.3Gw of Renewable Energy Projects are in Pipeline.AP govt has signed an MoU with Kia for creating electric vehicle ecosystem in the state[7]AgricultureThere is a myth that CBN never cares about Agriculture, but he is going shut all of their mouths with his work. He waived off about 24,000 Crores of loans for farmers, UP is going to study our loan waiver scheme. Almost 13,000 crores are done till now and the remaining will be done in the next couple of years. For the first time in the country, a special Budget for Agriculture was introduced.In the last 3 years, there are about 3.11 lakhs of Farm Ponds are being dug in AP. Data shows that the Center has built only 5,78,589 farm ponds. Andhra Pradesh has built 3,11,361 farm ponds, which is the highest by any State.He is planning to build 20,000 check dams in a year. AP government, along with ISRO, has prepared an action plan to meet drinking water and irrigation needs in drought-prone areas, the programme will be launched in Rayalaseema region soon.Rain Guns and innovative way of saving crop in drought is being brought in place. Subsidy on tractors, crop insurance, and farmer income support scheme of 15000 rupees(this includes centers Kissan Saman Nidhi 6000, State govt is paying an extra 9000 rupees)Special care for Polavaram the lifeline of AP, Made Every first day of Week Monday as Polavaram Day and inspecting it on the weekly basis after many years works are moving at faster pace, I’m sure polavaram will be completed under his leadership.When states like TN and Karnataka are fighting for Cauvery water he built a Lift Irrigation project called Patissema Lift and saved 100+ TMC of water to sent water to Drought hit Rayalaseema.AP is the first state in India to launch Plantix App for the farmers it can provide the information about the disease for the crop if any just with a photograph.Picture from training sessions to farmersStarted an amazing program called Manam-Vanam for planting trees and recently in recent ISFR 2017 rankings where India forest cover Increased by 1% and AP stood first with an increase of 2,141 sq km.One project that I like most w.r.t to the Agriculture sector is CBN is pushing farmers of AP into Natural farming. If you are interested to know more about it check it here[8]Healthcare:AP, first state in India to achieve Universal Health Security- Aarogya Raksha. It offers healthcare insurance to its citizens.[9]AP is the only state in the country to provide CT and MRI scanning free of cost at all district hospitals.Talli Bidda Express, A special Ambulance service for pregnant womenReforms in Education:A special organization named AP Janmabhomi was formed to connect NRI to its villages with 70% Government and 30% NRIS fund they are planning to convert 5000 government schools in AP to digital schools.For stopping girl child dropouts Government has introduced a special scheme to girl child's living in rural villages. Every girl child will get a new cycle for going to schoolTechnology in Administration:Our Chief is a big time believer of Technology here are some of the innovative things that make him so special. AP is the first state to have innovative dashboard[10] where we can track rainfall, street lights, groundwater levels and many more. It uses IOT first state in India to do so, many CMs don't even understand what IOT is. Many other states in India want to copy the same, recently Modi Govt launched similar kind of Dashboard on the occasion of completing 48 months in Govt.CBN is using Kaizala App to take feedback from it’s citizens. After giving feedback many of my friends got phone calls regarding the feedback provided in the App and how can they improve.We are going to take all departments online a project called e-pragati is floated and Microsoft is working with us.AP is the first state to have Skype Bot in Skype where you will be provided information about the AP Transport Department[11]CBN gave a Presentation about his vision for Andhra and What is trying to do in a Microsoft Event named Future Decoded if interested check that here[12].A citizen centric hotline has been started, dial in for 1100 and tell your problem, concerned team will look into it.AP Fiber provides the cheapest internet in India by a state government, Central government asked other states to follow AP Model. I have recently checked this in my hometown pretty impressed with the speed.You get 250 Channels, 5 GB of Unlimited internet and a Phone connection for 150 Rupees. The Box costs 5000 rupees which can be availed through EMI.AP disaster management is the first state in India to use technology that can locate the fall of a thunderbolt 30 minutes in advance. Citizens are alerted in that region via an SMS(Only for BSNL Network as of now)We have a technology for tracking the live rainfall, weather, etc. we developed that in association with ISRO.[13] Just go through the link you will love it.We have a Real Time Governance center for tracking the progress of all the departments.Real-Time Governance(RTG) center include Hitachi visualization suite for matrix surveillance and public safety first of its kind in India, Pentaho bi suite, for real-time data analytics, Barco video wall, the biggest laser-lit wall in India with 24 screens, Matrix camera analytics and data analytics from different departments are displayed on the laser-lit wall and processing in real time governance.Check out the Video by HitachiHitachi Resources - Search by Industry or ContentRecently Ambani hailed CBN for RTGCheck this out, Chandra Babu Naidu: Father of E-Governance a Video From DavosSmart Streets - A Pilot Project by Cisco and Govt of AP, First time in India.Don't Miss it, Have a look here:http://players.brightcove.net/1384193102001/NJgI8K0ie_default/index.html?videoId=5597494640001APIIC which has played a crucial role in getting investments to AP has its own tower now in MangalagiriCheckout the details of it here[14]Great Push to Tourism in Sunrise StateCBN always wanted Tourism industry in AP to develop right from his previous stint he is man who had vision to develop AP as most sought out tourist destination in India. 2000 hotel rooms will be added in AP in the next 2–3 years. Check out some amazing snaps of various places in AP here[15] .Recent Punnami Orvakal Festival, Festivals in Cities like Kakinada, Vizag and other places shows their effort in promoting tourism in APF1H20Kakinada Beach FestivalVisakha Utsav[16]Amaravati Global Music & Dance FestivalOrvakal Festival[17]Araku Ballon FestivalCheck out our Most beautiful Konaseema(AP’s Mini Kerala)[18]First of it’s Kind Nallamala Jungle Safari[19]Experience the Ooty of East Coast and Pristine beaches of Vizag[20]Indian Idol Revanth at recent Orvakal Festival.F1H20 AmarvatiFor more images of F1H20, checkout their official website[21]Araku Ballon Festival (Pic Credits: Suresh Gorantla)India’s biggest Marina is being developed at Amaravati in 3 acres of land with 60 berths.Building Smart VillagesModi gave a call for building smart cities but CBN has different vision he wants to make villages smart. A Pilot Project has been started and successfully implemented in a Village called Mori in East Godavari District. It’s one of India’s most hi-tech village. It’s 100% cashless, every house is connected with AP Fibre(Government Internet and Cable Connection), Water conservation, 100% ODF, Village is completely WiFi enabled, every citizen has a bank account and a solid waste management system.University of California Berkeley & Government of Andhra Pradesh has been working on it, Solomon Darwin (who is the director of Garwood Center[22]) a professor from UCB who hails from Andhra Pradesh is leading this project, Thanks to him and his team. Phase 2 works are going to start very soon now they are going to make 456 villages smart, I’m very impressed with this project and CBN’s vision of making villages smart.Some of the Investments that Came to AP after CBN taking charge:APP Sinar Mas (India’s Biggest FDI $3 Bn)KIA MotorsHero MotocorpMI, Gionee, Celkon, Karbon, Dixon, TCLMondelez International(Parent of Cadbury)ISuzu MotorsAsian Paints(India's largest plant in Vizag)Apollo TyresCEAT TyresMega Food Park in Kurnool500 Crores HCL Centre in AmaravatiXLr8 Andhra Pradesh[23]Several other Small IT & ITES in Vizag, Tirupati, and Vijayawada.Gamesa (Spanish Wind Turbine Company)Vijayanagara Food & Nutraceuticals Limited (India's first coconut processing unit in Vijayanagaram)Aparna Group is going to start a 320 Crore Tiles plant near Kakinada.Bharat Forge.GMR - Kakinada Special Investment Region: This could change the face of Kakinada in the coming days.Andhra Pradesh Medtech Zone Limited: India's first medical devices manufacturing unit in Vizag.Zoho in ReniguntaFranklin Templeton, Vizag[24]Conduent, VizagPi Data Center, Mangalagiri (One of Asia’s largest Data Center)BR Shetty’s Medicity Project in Amaravati (Est Investment $1.8 bn)Jairaj Steels, Kurnool(Est Investment $0.5bn)Ashok Leyland, Krishna DistrictHolitech ($200 Mn)Lixil Group ($60 Mn)Cardlytics, VizagSaint-Gobain[25], VizagSuzlon Energy Ltd, AnathapurBerger Paints, AnathapurAs on 5th March 2018No of Industries that are grounded in AP are 531[26]Amount of investment in Rs. crores 129661Employment Generated (No. of persons) 264754, AP has the lowest unemployment rate in the country.You can track the investments and employment stats here.Welfare Schemes for Poor in AP:Pensions for Old people, Widows, Single Women, Transgenders, Handicapped, hand loom workers, Toddy Tappers and Fishermen.There is a special ambulance service for AP pregnant women i.e 102 Ambulance ServiceChandranna Pelli Kanuka: A Scheme has explicitly been implemented for the welfare of the brides belonging to the backward classes and below the poverty line.Ammaku Vandanam[27] is a new scheme wherein mothers would be invited to the schools on a specific day every year for the special function. This is aimed at paying tributes to mothers and respect motherhood.NTR Videshi Vidyadharana Scheme provides 10 lakhs scholarships for all the people who are unable to afford foreign education.Yuvanestham a special scheme for unemployed youth, they will get 2000 monthly allowance to pursue skill development courses and reduce the burden on the family.Anna Canteens (Similar to Amma Canteens in TN) are opened across AP, Akshaya Patra Foundation is helping AP Govt in providing the meals.Divya Darshan A special scheme for Poor Hindus wherein Poor Hindus are taken on a free trip to Temples in AP, Currently for Tirumala[28].As far as my knowledge AP is the first state where Brahmins have a separate Corporation. Where poor Brahmins can get benefited from the following schemes [29]Awards and Achievements in the last three years:No: 1 in World Bank Ease of Doing BusinessNo: 1 in Private investments in India for the year 2015–16No: 1 in India in energy efficiency by World Bank.Best state in India by CNBCSeveral Awards in Power SectorUSIBC transformative CM for CBNBest CM Award from Bharatiya Chatra SansadAP is No: 3 in tourism in IndiaAP is able to ground 129661 Cr worth of Investments and generated 264754 JobsSector Wise Awards for AP from the past 5 yearsAP has so far received 667 awards in past 5 years from Central Government majority of them are in infrastructure, Power sector, Panchayat Raj and Rural DevelopmentI can say no other state in India has achieved so much as AP did in the past 5 years. I might have missed some and left out few things as the answer has become too big.Note:This is for people of Andhra PradeshGet to know what’s happening in your state and then comment about the leadership and all, most of the people I spoke don’t even know what’s happening they just comment as there is a problem with CBN ruling the state. Problem with our people is vested interests drive our state people don’t like this man for no reason. Many other states people admire him so much and want him as their CM, people of TN would happily take him as CM if offered they are the one who knows it better about the leadership Crisis. Some people of our state feel an actor turned politician a +2 dropout can change our state. Some feel South India’s King of Corruption can change this state. Grow up people when we have a leader who can turn things around why do you people look for options.Thanks for the upvotes.Footnotes[1] Fintech Valley Vizag[2] Amaravati masterplan | Foster + Partners[3] Review on Amaravati Capital City Roads Progress as on 06 Feb 2019[4] Kia Motors Global | Sedans, Hatchbacks, SUVs & MPVs[5] NATIONAL UJALA DASHBOARD[6] AP Vidyut Pravah[7] Andhra Pradesh government inks MoU with Kia Motors to introduce e-vehicles across State[8] Home - Zero Budget Natural Farming[9] NTR Arogya Raksha[10] CM DASHBOARD[11] AP Transport Authority[12] Future Decoded - Chandrababu Naidu[13] Vassar Labs[14] APIIC Tower | to be Inaugurated by CM Chandrababu | at Mangalagiri[15] AP Tourism (@Tourism_AP) | Twitter[16] VISAKHA UTSAV[17] Punnami Orvakal Festival[18] Konaseema[19] NALLAMALAI JUNGLE CAMPS[20] Home page - This Summer[21] F1H2O UIM World Championship[22] Home - Garwood Center for Corporate Innovation[23] XLr8 Andhra Pradesh[24] Franklin Templeton gets 40 acres to set up tech campus in Vizag[25] Saint-Gobain setting up glass unit in Vizag[26] http://164.100.47.190/loksabhaquestions/annex/14/AU1434.pdf[27] Andhra to introduce 'Ammaku Vandanam' in schools [28] దివ్య దర్శనం[29] ABC Schemes

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