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What is Ras?Ras is any protein part of the Ras superfamily of proteins related in structure. Ras is a ubiquitous protein expressed in all cells in our body. Ras proteins are part of a group of proteins termed the small GTPase class.Ras proteins are general involved in cell growth, differentiation, and survival. As you can see this makes the Ras superfamily of proteins the perfect candidate for contributing to cancer growth (unregulated proliferation and growth of cells). Ras specifically is involved in roughly 30% of human cancers[1].Ras proteins are part of complex, multifaceted signal transduction pathways that eventually lead to a these growth and proliferation signals which are transmitted via the nucleus.What exactly does signal transduction involve?Signal transduction is essentially the transmission of a signal from the outside of a cell to the nucleus inside. This signal results in alterations in cell metabolism, gene transcription (protein expression), and/or cell shape.There is generally a large amplification in signal as the agonist (binding signal) initially either binds on the outside of a cell membrane (as is the case for large hydrophilic molecules that will not be able to cross the hydrophobic phospholipid cell membrane) or on the inside of the cell (as is the case for hydrophobic steroid molecules that can cross the membrane with ease). This agonist causes a signal to be transmitted all the way to the nucleus. A signal agonist can cause an amplification in signal up to a million fold with ease.These pathways can be executed through a myriad of different cell receptors and pathways, some with higher levels of complexities and amplifications than others.For the purpose of our discussion, there are two main types of receptors: GPCR (G-protein coupled receptors) and RTK (receptor tyrosine kinases). The latter are much more heavily involved in growth, cell differentiation, etc. Both are involved in Ras activation.After the initial agonist binding to the receptor there is a few steps that are required for this signal to be transmitted which different slightly based on GPCR/RTK activation:Ligand --> Receptor --> Transducer/Effector --> Effector --> 2nd Messenger/Protein Kinase1) Ligand (agonist) binds to receptor. This can be done with an extra or intracellular receptor as previously described depending on the hydrophilic or hydrophobic characteristics of the ligand. In GPCRs this is a simple protein receptor, but with RTKs there can be an enzymatic activation of two protein receptors that causes them to link together and activate themselves and form one enzymatically linked receptor.2) Receptor sends the message to the transducer/effector, which then binds some sort of messenger to send the signal along. This is usually done by the phosphorylation of a protein that will carry this message forward. The point is that an activation must occur. Ras is activated by a protein called GEF and inactivated by a protein called GAP.This activation is reversed rather quickly in normal circumstances. In GPCRs this involves activation of a three subunit protein, whereas in RTKs it involves adaptor proteins that recruit the next protein required in the pathway.3) The transducer/effector (in this case Ras) sends the message to the last step of the pathway before the signal reaches the nucleus, the protein kinase pathway. This pathway (in this case the Raf/MEK/ERK pathway, also known as the MAP KKK pathway) will transduce the signal to the nucleus.Where do the problems arise?As you know, Ras is a small GTPase class of protein, and is a part of the signal transduction pathway which activates the protein kinase pathway and leads to the signal ultimately being transmitted. This activation is initially carried out through the GPCR or RTK and is turned off through a negative feedback loop from the products of the Ras pathway at the receptor/adaptor level. This normally stops the activation of the transducer/effector Ras.The problem arises when mutations in Ras occur - and they occur quite often in cancer patients. Once a mutation in Ras has occurred, it becomes permanently turned on and the pathway does not cease to stop. Even if the adaptor proteins or receptors receive the signal to stop activity it does not matter because Ras itself has mutated to decrease its own GTPase activity. As the exchange of GTP for GDP and the subsequent GTP hydrolysis stops due to the mutation, GTP stays bound to the Ras protein and unregulated cell proliferation and growth ensues.Not only does GTPase activity decrease, but the Ras protein loses sensitivity to GAP (one of the regular inhibitors of Ras)[2][3][4] and is exposed to a larger quantity of GEF (one of the regular activators of Ras through GTP binding)[5][6].Thus, we can say that the problems arise through 3 main mechanisms:1) Mutations in the Ras protein itself that lead to decrease GTPase activity, and therefore a constantly bound GTP molecule and permanent activation of Ras.2) Overactivation of the wild-type protein that leads to the production of GEF.3) Loss of GAP function due to the decreased sensitivity of the Ras protein.So why can't we inhibit Ras once it has mutated?Pharmaceutical companies have been spending billions of dollars in trying to inhibit Ras once it has been mutated. However, these companies have had only minimal success, if any at all.The first approach has been taken in regards to the disrupting the Ras to GTP binding, but none have succeeded.1) Using competitive inhibitors for the enzymatic active site of Ras. This actually backfired because any molecule that could function to do this would actually further impede any potential GTPase activity. This inactivity gives Ras its oncogenic activity in the first place. Regardless, the only molecules that have been found to achieve this function are clostridial cytotoxins (a type of bacterial toxin), and these toxins work enzymatically to create a Ras protein that is covalently modified, causing Ras to become resistant to GAP entirely. Using an molecule to do the opposite, creating an agonist, would be very difficult (restoring GAP sensitivity or GTPase activity) and it has been shown that it may not be feasible at all[7].2) Developing a drug in attempt to displace GTP from Ras. This has proven a dead end road due despite its promising nature. Due to the high kinetic affinity between the binding of Ras to GTP, the ATP binding site drug competitors on the market cannot compete (micro molar vs nano molar affinities).Disrupting the Ras to GTP high affinity binding has been characterized as "undruggable" in a recent 2010 study[8]. There is still enthusiastic chatter in this arena but so far no one has further succeeded in this task.Some have also tried to disrupt the upstream GEF activator protein (SOS in the previous image)[9][10]. However, nothing yet has been developed to show major promise.This has left us with the absence of an obvious molecule on the level of Ras to target. The next focus has been involved in the construction of Ras itself.Post-translation covalent protein modifications are essential to the formation of Ras, and so it has been suggested that it may be a good target to go after the tools involved in those modifications - specifically farnesyl transferase. Theoretically, disruption of the proteins post-translational modifications would result in a non-functional protein. Furthermore, it was hypothesized that the presence of inactive Ras would act as an inhibitor to previously active Ras signalling through the sequestering of molecules to the proper sub cellular locations involved in its signalling pathways.This approach has involved using farnesyl transferase inhibitors (FTIs). A couple of these FTIs actually made it all the way to phase 3 clinic trials after showing promising results before it was shown to lack the anticipated anticancer activity[11].So why did this not work? Most likely because they drugs were developed using a mutated version of an isoform of Ras. The belief was that all isoforms of Ras would respond similarly, but that unfortunately is not the case. It has been shown that the active in vivo isoforms of Ras become geranylgeranylated in cells in the presence of FTIs, which allows them to bypass the action of the FTIs and develop fully. Nothing further has been developed in this area, but it is possible that FTIs will produce benefits in the future.Another focus has been on Ras at the expression level. In other words, scientists have been trying to reduce the expression of particularly harmful isoforms.Targets for this approach include promoters of specific isoforms of Ras such as the guanine-rich sequence forming a G-quadruplex structure which has been confirmed in human DNA[12]. Many drugs are already available on the market which can bind and stabilize these G-quadruplex DNA structures and can regulate expression of Ras in vitro.However, regulatory activity of these structures can be negative or positive in vivo depending on the isoform of Ras. Also the sequences that are compatible with these structures are widespread within human DNA. Therefore it is unlikely that this will provide a proper mechanism for stopping Ras.Pieces of regulatory RNA called microRNAs (specifically microRNA-622) are also being tested which have been shown to decrease specific isoforms of Ras. It is unknown how efficacious this path will turn out to beThe last major focus has been with the protein kinase pathway. Inactivating the MAP KKK pathway you have previously learned about would cause the Ras signal to cease before it could cause any damage. A major problem with this approach is that it is so far downstream from the source of the problem.Since the oncogenic signal from Ras is transmitted through multiple pathways it has been speculated that this will not prove to be very effective[14][15][16][17][18][19][20]. Despite this, FDA approval of one of these inhibitors (trametinib) has been granted. Another MAP KKK inhibitor, MEK162, has shown promising results also in melanoma patients[13].For this approach to be effective the MAP KKK signally pathway would have to predominate the signal transduction pathway from Ras. Another problem with this approach is that resistance could easily emergence with these inhibitors.There are other newer methods being developed of Ras, but it's unclear if any will prove to be useful at this point. Scientists are continually still working to stop Ras and will most likely continue to do so until they find a way as the benefits of such a discover would have a very high payoff for humanity.What happens if we do block Ras?There will still be complications even if we do find a way to simply block the actions of Ras, as Ras is involved in widespread functions in the human body.To give one example, it has been shown that Ras is part of an important pathway for synaptic remodelling in the human brain (the very process that underlies memory)[21]. Mutations in regulators of Ras in neutrons are found in patients with non syndromic mental retardation[22]. There is also evidence that the H-Ras isoform is involved in control of synaptic plasticity[23].This is just one more example in the challenges that we still have yet to face in blocking Ras.References:A. T. Baines, D. Xu, and C. J. Der, “Inhibition of Ras for cancer treatment: the search continues,” Future Medicinal Chemistry, vol. 3, no. 14, pp. 1787–1808, 2011.J. B. Gibbs, I. S. Sigal, M. Poe, and E. M. Scolnick, “Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules,” Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 18, pp. 5704–5708, 1984.G. Bollag and F. McCormick, “Differential regulation of rasGAP and neurofibromatosis gene product activities,” Nature, vol. 351, no. 6327, pp. 576–579, 1991.U. Krengel, I. Schlichting, A. Scherer et al., “Three-dimensional strucutures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules,” Cell, vol. 62, no. 3, pp. 539–548, 1990.K. Zhang, A. G. Papageorge, and D. R. Lowy, “Mechanistic aspects of signaling through Ras in NIH 3T3 cells,” Science, vol. 257, no. 5070, pp. 671–674, 1992.R. R. Mattingly and I. G. Macara, “Phosphorylatlon-dependent activation of the Ras-GRF/CDC25(Mm) exchange factor by muscarinic receptors and G-protein βγ subunits,” Nature, vol. 382, no. 6588, pp. 268–272, 1996.K. Scheffzek, M. R. Ahmadian, W. Kabsch et al., “The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic ras mutants,” Science, vol. 277, no. 5324, pp. 333–338, 1997.T. Tanaka and T. H. Rabbitts, “Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth,” Oncogene, vol. 29, no. 45, pp. 6064–6070, 2010.T. Maurer, L. S. Garrenton, A. Oh et al., “Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 14, pp. 5299–5304, 2012.Q. Sun, J. P. Burke, J. Phan et al., “Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation,” Angewandte Chemie International Edition, vol. 51, pp. 6140–6143, 2012.A. M. Tsimberidou, C. Chandhasin, and R. Kurzrock, “Farnesyltransferase inhibitors: where are we now?” Expert Opinion on Investigational Drugs, vol. 19, no. 12, pp. 1569–1580, 2010.G. Biffi, D. Tannahill, J. McCafferty, and S. Balasubramanian, “Quantitative visualization of DNA G-quadruplex structures in human cells,” Nature Chemistry, vol. 5, pp. 182–186, 2013.P. A. Ascierto, D. Schadendorf, C. Berking et al., et al., “MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study,” The Lancet Oncology, vol. 14, pp. 249–256, 2013.K. R. Stengel and Y. Zheng, “Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting,” PLoS ONE, vol. 7, Article ID e37317, 2012.N. Mitin, K. L. Rossman, and C. J. Der, “Signaling interplay in ras superfamily function,” Current Biology, vol. 15, no. 14, pp. R563–R574, 2005.A. V. Patel, D. Eaves, W. J. Jessen et al., et al., “Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target,” Clinical Cancer Research, vol. 18, pp. 5020–5030, 2012.S. Eser, N. Reiff, M. Messer et al., et al., “Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer,” Cancer Cell, vol. 23, pp. 406–420, 2013.H. Y. Chow, A. M. Jubb, J. N. Koch et al., et al., “p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model,” Cancer Research, vol. 72, pp. 5966–5975, 2012.R. E. Menard and R. R. Mattingly, “Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways,” Cellular Signalling, vol. 15, no. 12, pp. 1099–1109, 2003.Q. Li and R. R. Mattingly, “Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in ras-transformed breast epithelial cells,” Neoplasia, vol. 10, no. 12, pp. 1444–1458, 2008.E. J. Weeber and J. D. Sweatt, “Molecular neurobiology of human cognition,” Neuron, vol. 33, no. 6, pp. 845–848, 2002.L. B. Rosen, D. D. Ginty, M. J. Weber, and M. E. Greenberg, “Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras,” Neuron, vol. 12, no. 6, pp. 1207–1221, 1994.K. A. Rauen, “HRAS and the Costello syndrome,” Clinical Genetics, vol. 71, no. 2, pp. 101–108, 2007.

STOCKHISTORY function - Office Supporthttps://support.microsoft.com/en-us/office/stockhistory-function-1ac8b...The STOCKHISTORY function syntax has the following arguments: Argument. Description. stock. Function returns historical price data about the financial instrument corresponding to this value. Enter a ticker symbol in double quotes (e.g., "MSFT") or a reference to a cell containing the Stocks data type. This will pull data from the default exchange for the instrument.Microsoft Excel’s new STOCKHISTORY function gives you ...Microsoft Excel’s new STOCKHISTORY function gives you access to historical stock data - MSPoweruser2020-07-01 · To solve this issue, Microsoft Excel is introducing a new function called STOCKHISTORY. STOCKHISTORY function signature: STOCKHISTORY(stock, start_date, [end_date],[interval],[headers], [property0], [property1] [property2], [property3], [property4], [property5]) stock: The identifier for the financial instrument targeted. This can be a ticker symbol or a Stocks data type.Videos of How Do You use the STOCKHISTORY Function in Excel?A fortress in the sky9:20NEW STOCKHISTORY Function in Excel | Get Stock History & Currency Conver…490 views5 months agoYouTubeExcel Bonanza4:51STOCKHISTORY Function In Excel - Episode 23345.4K views5 months agoYouTubeMrExcel.com17:33New Excel STOCKHISTORY Function - Definitive Guide12K views5 months agoYouTubeMyOnlineTrainingHub6:05Pull Stock History into Excel w/ the Stock History Function5.2K views5 months agoYouTubeChris Menard8:10English - STOCKHISTORY Function In Excel (mac & windows)646 views5 months agoYouTubeFaraz ShaikhSee more videos of How Do You use the STOCKHISTORY Function in Excel?Excel STOCKHISTORY Function • My Online Training Hubhttps://www.myonlinetraininghub.com/excel-stockhistory-function2020-06-18 · Of course, you could nest the SEQUENCE function inside STOCKHISTORY like so: =STOCKHISTORY(B24:B29,SEQUENCE(1,5,43994,-1),,0,0,1) However, you can’t display the headers with this formula, so I thought it made more sense to use SEQUENCE for the headers, and reference them in the start_date argument. Formatted Number Values (FNVs)Historical Stock Quotes with STOCKHISTORY - Excel UniversityHistorical Stock Quotes with STOCKHISTORY - Excel University2020-09-09 · In general, when we provide a ticker and start date to the STOCKHISTORY function, it will retrieve closing prices from third-party data provider Refinitiv. The function has many options and arguments, so you’ll want to explore them here. Here are the basic arguments: =STOCKHISTORY(stock, start_date, end_date, interval, headers, properties...) Where: stock is the ticker; start date is the first …Stock & Exchange Rate History in Excel - Excel Tips ...Stock & Exchange Rate History in Excel2020-06-29 · A new STOCKHISTORY function debuted in the beta channel of Excel for Office 365 last week. The function is able to pull historical stock prices and exchange rates at a daily, weekly or monthly interval. STOCKHISTORY is an example of one of the new Dynamic Array formulas. A single formula will spill into adajent cells.How to use the STOCKHISTORY function in excel - QuoraHow do you use the STOCKHISTORY function in excel?How to use the STOCKHISTORY function in excel - Quora With the new STOCKHISTORY function in Excel, we can pull the Historical data of Stocks Prices and Currency exchange rates into an Excel worksheet. Following is the syntax of STOCKHISTORY function [code]=STOCKHISTORY(stock, start_date, …Microsoft STOCKHISTORY allows users to visualise history ...https://www.msn.com/en-in/news/other/microsoft-stockhistory-allows...STOCKHISTORY will make use of this function to display historical stock data. STOCKHISTORY makes it easier to track and recover changes to the stock data. Additional benefits of using a Stocks data...Announcing STOCKHISTORY - Microsoft Tech Communityhttps://techcommunity.microsoft.com/t5/excel-blog/announcing-stock...2020-06-11 · Announcing STOCKHISTORY Getting started is simple. This can be a ticker symbol or a Stocks data type. You can find more detailed explanations of... Examples. You can get started by using the ticker symbol as a textual representation of the stock. The start_date and... Getting Fancy. Let’s see …Stockhistory function - Microsoft CommunityMicrosoft 365 and Office...2020-06-17 · It's a way to control quality and compare two groups of users. It's random with each update. You may even get a new feature this week and not have it the next. Test with each week's build. You can click the little Help Improve Office button in the upper right corner of the worksheet and ask to have the feature. That might help.stockhistory - Microsoft Community2020-11-05Stockhistory- when?2020-10-06Insider Beta Excel; Stock History function2020-07-31Internal support function returned an error; Office 365 ...2020-03-05See more resultsGet Current and Historical Stock Prices into Excel - Excel ...Get Current and Historical Stock Prices into Excel - Excel University...2019-07-15 · (Note: converting your ticker list into a Table isn’t required, it just makes this feature easier to use). You can select the tickers, then click the Data > Stocks command in the Data Types group. When you do, Excel attempts to convert those static text values into stocks (Figure 2).

Washington State Department of TransportationContact WSDOTConcernsLicensing - The Washington State Department of Licensing handles the licensing and regulating drivers, vehicle and boats.Ferries-related 1-888-808-7977 or 206-464-6400Pay a Toll - Good To Go! 1-866-936-8246Report graffitiWebsite feedback and general questionsSpecific areasPrograms and servicesOfficesEmployeesOther inquiriesHow do I?Subscribe/Unsubscribe to emails and text messagesWSDOT Headquarters360-705-7000 / 360-705-7438Staffed 8 a.m.-5 p.m., Monday-Friday except state holidaysMailing Address:Washington State Department of Transportation310 Maple Park Avenue SEP.O. Box 47300Olympia, WA 98504-7300Persons who are hard of hearing may call Washington State Telecommunications Relay Service (TTY) at 711.cost effective method of soil compaction whereby a heavy weight is repeatedly lifted and dropped from a height, impacting the ground surface with a readily calculated impact energy . Costs are reportedly about 2/3 that of stone columns, with up to 50% savings over other deep densification alternatives (Washington State Department of Transportation). Dynamic compaction is one of the oldest soil improvement methods known, reportedly used by the Romans prior to 100 ad and in the United States as early as the 1800s (Welsh, 1986).The name does not accurately portray the actual loading and energy transmission processes. One of the greatest misnomers regarding dynamic compaction is that it is a surface ground treatment, as loads are applied at the surface. But dynamic compaction, as opposed to conventional shallow compaction of controlled fill, is a process of densifying soils at significant depths by applying a large impact energy at the ground surface. Upon impact, craters as deep as six feet or more are created, which must then be backfilled prior to additional compaction passes and ultimately at the completion of the compaction process. But the densification at depth occurs as a result of the dynamic wave energy that is transmitted through the ground.The main objectives of dynamic compaction are to improve strength and compressibility characteristics by either creating a uniform raft of densified material, or by compacting at locations where concentrated loads (e.g., column loads) will be applied. Improved soil properties result in increased bearing capacity and reduced settlements, including differential settlements. Dynamic compaction often allows for construction of conventional spread footings by providing bearing capacity of typically as much as 100-150 kPa (2000-3000 psf).Dynamic compaction is suitable for densification of loose sand deposits such as those typically occurring in coastal, glacial, and alluvial deposits, as well as for dredged or hydraulically placed fills. This method has also been successfully applied to mine tailings, landfills, collapsible soils, sites underlain by sinkholes, and so forth (Zekkos et al., 2013). It is one of the better alternatives to densification of heterogeneous fills, and fills containing large debris that may create obstructions for other remediation techniques, such as stone columns or rigid inclusions (Menard Group, world specialist in ground improvement). Results are best for well-drained, high permeability soils with low saturation, although some satisfactory results have been reported for improvement of silty soils with the aid of PVDs or stone columns (or composite stone columns employing supplemental PVDs), and by providing time delays to allow for the dissipation of generated pore pressures (Dise et al., 1994; Shenthan et al., 2004). In certain conditions, saturated soils will be temporarily liquefied, allowing easier rearrangement and ultimately a tighter, denser packing upon dissipation of pore pressures. Because of this phenomenon and the benefits it can provide, “rest periods” between drop phases are sometimes specified, during which pore pressure dissipation can be monitored with piezometers to assure completion. This method is not appropriate for saturated clay soils.Applications consist of dropping a heavy tamper (weight) from a specified height a calculated number of times at precisely determined locations in a pattern at the site. Drop patterns usually consist of primary and secondary (and occasionally tertiary) grids such as depicted in Figure 6.14. Grid spacing is typically about 3-7 m (9-21 ft). The weights typically range from 6 to 30 tons (up to 40 tons), and the drop heights typically range from 10 to 30 m (30-100 ft), sometimes more.Effective densification is typical to depths of 10 m (or more with very big rigs and weights). The greatest improvement usually occurs between 3 and 8 m (10-25 ft) below the ground surface, with diminishing degrees of improvement at greater depths. The surface layers (surface to approximately 1-3 m) must be recompacted due to the disruption by the impact loads and lack of sufficient confinement. In order to estimate the required compaction effort using dynamic compaction, the Menard formula is generally followed:(6.2)[math]Z=nMH[/math]where Z is the (required) treatment depth, M the tamping mass (tons), H the fall height, n the (soil dependent) constant, typically between 0.3 and 0.6 for sandy soils.Greater depths have been effectively densified using a system known as high energy dynamic compaction, where maximum efficiency is achieved with the complete free fall of the weight through the use of a specially designed weight release system (Menard Group, world specialist in ground improvement). As an extreme case, Menard developed a “Giga” compactor for deeper densification at the Nice airport in France (Figure 6.15).Sign in to download full-size imageFigure 6.15. Menard’s “Giga” compactor drops a 200 ton weight.Courtesy of Menard.Designing a dynamic compaction project application requires determining the most efficient application of energy at the site. This may be initially determined based on data from site investigations. Actual DDC program applications are typically fine-tuned, or modified, based on test sections or after field testing of preliminary applications (i.e., after an initial phase of drops). Field measurements of penetration (or “crater depths”) and pore pressures are continuously monitored to allow for adjustments to the field program. Measurements of crater depths are also used in a manner similar to proof rolling in that deeper crater depths indicate “softer” or “weaker” locations that may require further attention.View chapterPurchase bookSoil compactionAnjan Patel, in Geotechnical Investigations and Improvement of Ground Conditions, 20192.6 Dynamic compactionIn dynamic compaction, a large weight usually of 100–400 kN is dropped repeatedly from a height of about 5–30 m onto the ground using a predetermined grid pattern, as depicted in Fig. 2.6, in order to densify the soil mass or to improve its compactness.Sign in to download full-size imageFig. 2.6. Dynamic compaction. (A) Dropping of weight from a certain weight (Menard), (B) Drop locations.The maximum effective depth of compaction using dynamic compaction can be determined by using the formula as follows:(2.1)[math]Dmax=nWH1/2[/math]where W is the dropped weight in tonnes, H is the height of drop in metres and the value n is a factor that depends upon the type of soil. This depth is also influenced by other factors such as the stratigraphy of the soil, the degree of saturation, the way in which the weight is dropped, and the presence of any damping soil layers. The value of n generally varies from 0.4 to 0.8. The number of drops at each grid point location can be calculated using Eq. (2.2) as follows:(2.2)[math]E=N·W·H·P/S2[/math]where E is the applied energy, N is number of drops at each grid point location, W is dropped weight, H is the height of drop, P is number of passes, and S is the grid spacing. The drop point spacing is generally selected as 1% to 2% times the diameter or width of the dropped block.The dynamic compaction method can be used for various applications such as for the treatment of industrial warehouses, port and airport platforms, roads and railways embankments, heavy storage tanks, nonorganic heterogeneous fill or man-made ground containing larges blocks as obstructions, and soils that are susceptible to liquefaction. The major advantage of adopting the dynamic compaction method is its very high production rate (it can be used to treat an area of > 104m2/month). Moreover, this method is effective both in saturated and nonsaturated soils. In soft ground, the method of dynamic compaction has been proved as a better alternative to preloading, foundation piling, or soil undercutting and replacement.However, the disadvantage or difficulty in adopting the dynamic compaction method is that it requires an intensive in situ testing programme (standard penetration test, cone penetration test, pressure meter test or load settlement test, etc.) to verify that the desired improvement has been achieved in the field. Moreover, constant monitoring is required to check for the formation of crater, ground heave, ground vibration, induced settlement, and pore pressure development during the operation of this method on the site. This method becomes more complicated in silty and clayey deposits below the groundwater due to its relatively low permeability. In such cases, if the energy level is very high, instead of densifying the soil mass, it may bring the ground to a liquefaction state for a longer duration with negligible pore pressure dissipation. To tackle this problem wick drains associated with dynamic compaction are sometimes provided. Also, the dropping of the weight can be scheduled into phases allowing a certain period of time for the dissipation of pore pressures at each drop point location. Otherwise, the dynamic compaction method is modified to what is known as high energy pillars, where, with the help of high tamping energy, large-diameter stone pillars are created in a soft soil. In cases where the water table is close to the ground surface, dewatering is done to lower the level temporarily to at least 2 m below the surface or the ground level is raised to bring the platform suitably above the water table to allow for the dropping of weights.View chapterPurchase bookDynamic Compaction and Dynamic Consolidation of SoilsNathan Narendranathan, Eng Choy Lee, in Ground Improvement Case Histories, 201512.2.1 Deep dynamic compaction with drop weightsThe deep dynamic compaction (DDC) technique involves using a crane to drop weights of between 5 and 20 tons, from heights of up to 20 m. Figure 12.1 technique is best suited to large, open sites where few obstructions are present.Sign in to download full-size imageFigure 12.1. Example of deep dynamic compaction.Depending on the weight used and the drop height, the depth of treatment could vary from 8–20 m in sands. The number of drops, weights used, and the height of the drops depend on the required posttreatment bearing capacity, settlement performance, and soil conditions. Between two and five passes are generally required with the first or earlier high-energy treatment passes aimed at treating the deeper soil layer and a final low-energy contiguous tamping pass to compact the shallow near-surface soils disturbed during the earlier higher energy treatment passes. DDC is commonly used in reclaimed areas and landfill rehabilitation to provide a strong ground with less susceptibility for settlement or differential settlement.The authors’ experience has shown that DDC can be used in clays in combination with prefabricated vertical drains or jute drains that can withstand the impact of the drop weight.View chapterPurchase bookImproving Geotechnical Properties of Closed Landfills for Redevelopment Using Chemical Stabilization TechniquesBehnam Fatahi, ... Behzad Fatahi, in Ground Improvement Case Histories, 20158.3.1 Improvement techniquesThe deep dynamic compaction (DDC) technique is a common ground improvement technique because of its economical application. Zekkos and Flanagan (2011) reviewed 64 case histories with respect to the effectiveness of DDC on MSW landfill sites. With DDC, large voids are reduced, and subsequently other techniques such as fly ash–lime grouting can further decrease the remaining smaller voids. In addition, the lime/fly ash slurry injection has a significant impact on protecting groundwater, neutralizing leachate. Several research works have been published on the chemical stabilization of problematic soils incorporating some waste products such as carpet fibers (Fatahi et al., 2012, 2013a, b). Replacement of cement with by-product materials such as fly ash can further reduce the expenses associated with stabilization. Many researchers have reported the application of fly ash in geotechnical projects (Kawasaki et al., 1981; Kehew, 1995; Kitazume et al., 2000; Hokmabadi et al., 2014a, b). Horpibulsuk et al. (2012) reported that from an economic and environmental standpoint, rich materials in slaked lime (Ca(OH)2, calcium hydroxide) can be treated together with pozzolanic materials, such as fly ash, to develop a cementitious material. A series of laboratory permeability tests on decomposed MSW, using chemical agents, have been conducted to quantify the behavior of stabilized MSW samples.View chapterPurchase bookDeep Compaction of Granular Fills in a Land Reclamation Project by Dynamic and Vibratory Compaction TechniquesMyint Win Bo, ... Mahdi Miri Disfani, in Ground Improvement Case Histories, 20158.5 ConclusionThree deep compaction techniques—MRC, vibroflotation, and dynamic compaction—relevant for land reclamation projects have been discussed in this chapter. The following conclusions can be drawn:•All three techniques were found to be suitable for the densification of land reclamation fills.•The type of equipment, spacing of points, duration of compaction, and other operational considerations are of importance in the application of these techniques.•In the MRC technique, the selected frequency should be about the soil resonance frequency, and degree of compaction is found to be consistent with distance from the probe point.•In the vibroflotation technique, degree of compaction is found to decrease with distance from the probe point.•In dynamic compaction, the centroid point is found to be the most compacted point in the dynamic compaction technique, with the location directly beneath the pounder found to be the least compacted point.•An aging effect is significant for the vibroflotation technique, but it is not found to be significant for the other techniques. This can be attributed to the required injection of water or water jetting, which is applied in the vibroflotation technique, and the subsequent dissipation of pore water.View chapterPurchase bookDynamic Compaction and Dynamic Surcharging at Dubai’s Palm Jumeira Sewage Treatment PlantsBabak Hamidi, Serge Varaksin, in Ground Improvement Case Histories, 201510.3 ConclusionThis project demonstrated the effectiveness of combining dynamic surcharging and dynamic compaction for improving the ground and achieving results that would have been otherwise difficult, if not impossible, to achieve. Dynamic surcharging was able to induce additional settlements compared to what was realized under static loading conditions. This has not only shown the value of dynamic surcharging for increasing induced settlements and reducing soil porosity, but is also a reminder that even if settlements are acceptable under static loading conditions, vibration of the ground due to earthquakes or any other source can impose more settlement. In conclusion:1.Dynamic surcharging can be used to increase induced foundation settlement under static surcharge by 1.3–5 times, depending on the distance from the pounder impact point, to treat silty material that would normally not be treatable by dynamic compaction, and to increase the depth of treatment.2.Although the settlement magnitude of dynamic compaction was much more than dynamic surcharging, the latter induced critical settlement at depths that were treated less effectively with the allocated pounder.3.Excluding the highest values, average PLMand EM, respectively, ranged from approximately 2–4 MPa and from 23–30 MPa at depths of about 4–8 m. These values are significantly higher than what was suggested by Lukas (1986).4.Maximum improvement ratios were in the range of 10–18, which are significantly higher than the range that was suggested by Lukas (1986).5.Due to the combination of dynamic surcharging and pre-excavated dynamic compaction with a high number of blows, improvement can still be observed at greater depths.Fig. 10.23 shows Tank G-G after construction.Sign in to download full-size imageFigure 10.23. Tank G-G after construction.View chapterPurchase bookThe Changi East Reclamation Project in SingaporeMyint Win Bo, ... Victor Choa, in Ground Improvement Case Histories, 20159.4.3 Deep compaction of sand fillThree types of deep compaction methods were deployed to densify the granular soil: dynamic compaction, MRC, and vibroflotation. The dynamic compaction method was used in the area where the required depth of compaction was 5–7 m. The MRC and vibroflotation methods were adopted in the areas where the required thickness of compaction was 7–10 m.The effectiveness of dynamic compaction is dependent on the combination of weight, geometry of pounder, height of drop, spacing, number of drops, and total compactive energy applied. Experiments with different weight of pounder, height of drop, spacing, and number of drops were performed onsite to establish the most cost-effective combinations. The results of one of the experiments are shown in Fig. 9.18. The pounder used was 23 t. The height of drop was 25 m. The spacing between the pounding point was 7 m × 7 m. Only one pass of compaction was used. The number of drops per pass was 10. The total energy per point was 575 tons/m.Sign in to download full-size imageFigure 9.18. Cones resistance measured at various loctaions for 7m × 7m grid spacing (1) under the print, (2) intermediate point, (3) centroid point.After compaction, CPT tests were carried out at three locations, as indicated in Fig. 9.18. The CPT results obtained from the three locations are presented in Fig. 9.18. The variation of cone resistance with the location or the distance from the pounding point can be clearly seen. The cone resistance achieved at the center of the pounding grid (point 1) was greater and more uniform than that at the pounding point itself (point 3). The cone resistance achieved at point 2, which was between the pounding point and the center of the grid, was in-between the cone resistance obtained at those two points. Based on the experiments, four compaction methods, as detailed earlier in Table 9.3, were selected and used in the project. A comparison of CPT cone resistances obtained before and after compaction conducted at a number of locations using Method 1 (see Table 9.3) is presented in Fig. 9.19. The effectiveness of the dynamic compaction can be clearly seen in the figure.Sign in to download full-size imageFigure 9.19. Comparison of CPT cone resistance obtained before and after dynamic compaction at various locations.MRC does not require water for penetration. In this method, a steady-state vibrator was used to densify the soil. As a result of vibratory excitation, the friction between the soil particles is temporarily reduced. This facilitates rearrangement of particles, resulting in densification of the soil. A specially designed steel probe was attached to a vibrator, which had variable operating frequencies. The frequency was adjusted to the resonance frequency of the soil, resulting in strongly amplified ground vibrations and thereby achieving an efficient soil densification. Two types of MRC equipment and probes, as detailed in Table 9.4, were used. Experiments were carried out onsite to study the effect of the MRC compaction. CPTs were used to evaluate the compaction results.The results of one experiment using the MRC MS-200 H system are presented in Fig. 9.20. MRC tests were conducted at a square grid of 5 m × 5 m (see Fig. 9.20). CPT tests were conducted at five locations of an even spacing of 1.25 m in-between two MRC compaction points. The cone resistance versus depth profiles obtained at the five locations before and after compaction are shown in Fig. 9.20. It can be seen that substantial improvement was achieved at every point mainly within a depth of 4–10 m and the effect of densification does not appear to be significantly affected by the distance from the compacting points with the grid. The sand fill before compaction appears to have been mysteriously densified, possibly by seepage force or cementation at depths near 1 and 4.5 m, as indicated by the high CPT values at those two locations. However, this localized densification effect, if it was real, had been destroyed by MRC compaction. Nevertheless, as the sand fill was recently deposited, cementation or other effects would not be a consideration.Sign in to download full-size imageFigure 9.20. Variation of cone resistance with distance from the probe point after compaction.Several types of vibroflotation equipment, either electrically or hydraulically driven, were used in the project. The differences in the various types of vibroflotation equipment are shown in Table 9.5. Among the three types of vibroflotation equipment, the power rating is the same, but the centrifugal forces are different. The model numbers signify the amplitude. The amplitudes for V23, V28, and V32 are therefore 23, 28, and 32 mm, respectively. Keller S-300 type uses a higher power rating, but low centrifugal force and amplitude. Pennine type has a high centrifugal force and amplitude and its dimensions are all the largest of the three plant types. The spacings used for each piece of equipment to achieve the respective densification requirements are shown in Table 9.6. Onsite experiments were also conducted to study the effect of the vibroflotation compaction.The results of one study are shown in Fig. 9.21. Vibroflotation compaction using the V32 model at the 3.2 m triangle grid pattern shown in the figure was conducted. CPT tests were conducted at five locations evenly distributed between two compacting points. The cone resistance profiles obtained before and after compaction at each CPT test points are given in the figure. The results show that the effect of vibroflotation compaction is affected by the distance to the compacting point or the position in the compaction grid. The cone resistance is the highest at the probe point and the lowest near the center point of the triangle (CPT points 2 and 4). However, cone resistance at the center of the four compaction points (point 3) is higher than that at points 2 and 4. On the other hand, the improvement appears to be effective through the entire depth ranging from 1–10 m with more significant improvement felt at the bottom (see CPT profiles for points 1 and 5).Sign in to download full-size imageFigure 9.21. Variation of cone resistance with distance from the probe point after compaction.Each of the three compaction methods has its own advantages and disadvantages depending on the site and soil condition in the various areas. The dynamic compaction method produces a relatively more uniform degree of densification in each layer. However, the depth of densification is limited to 6 or 7 m. The MRC method is able to compact with a wider spacing and compact the sand at a relatively deeper depth. However, the probe needs to be maintained frequently as a result of wear and tear. The vibroflotation method can compact to a greater depth. The degree of densification is uniform along the depth, but can vary significantly with the distance from the probe points. It requires a smaller grid spacing and a sufficient supply of water.It has been reported by Mitchell (1986) that there is an ageing effect, that is, an increase in the CPT cone resistance with time, after densification in sand has been carried out. Such an ageing effect varies with the mode of compaction as far as the observations made in this project are concerned. As reported by Bo and Choa (2004), the ageing effect was the highest in vibroflotation-compacted sand. The ageing effect was not significant in sand compacted by dynamic compaction. One example is given in Fig. 9.22. The ageing effect due to MRC compaction is in-between that of vibroflotation and dynamic compaction.