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Hi I wish to pursue masters in mechatronics from Germany. I have completed my BTech in mechanical engineering with CGPA of 7.5. Is it possible to get admission in public universities, I have done internships for 4 months will it be of any help?

Hey,I hope you are fine and doing good.Yes!. You can! The cgpa you mentioned is a decent score and 4 internships adds well to your profile.Germany requires 13 years of education background. However, if we are not having 1 extra year of education, then Studienkolleg is compulsory. It is a foundational course that is having two semesters and it will help you gain mastery in german language which is a compulsory thing if you want to study in Germany.Other than this:Select the university and Bachelor's program.You should know the requirements of the university you are applying in. We can help you in it. Feel free to contact us.Some important documents required are:• High school qualification• Your grades from previous education• Entrance qualification• German language proficiency• Completion of Studienkolleg course• Personal documents likeOther than these, some more documents required are:• Resume/CV• Letters of recommendation (minimum two)• Passport sized photos• Copies of your passport• GMAT/GRE test certificates• Medical certificate• Insurance letter• Documents stating work experience• Course specific questionnaire• Test AS certificate• Translations of certificates• Proof of funds● Learn the German languageBefore taking admissioin in German universities, you will need to learn german language in the following stepsA1 : BeginnerA2 : ElementaryB1 : IntermediateB2 : Upper intermediateC1 : AdvancedC2 : Highly competentAnd if you don't want to pursue the degree in German then you can find a university that offers the course in English and the you will need to clear your GRE/IELTS/TOEFL (as required by the university)I hope it helps!Feel free to contact us for more information.Thank you!

Is there any research on ATP/ADP, Glycolysis, Krebs cycle relating to Chronic Fatigue Syndrome / Fibromyalgia Syndrome?

I don’t know of any research, at least any research that get’s it right, that ties the whole thing together. I’m not a doctor. Electronic medical records is something I have worked with since 1979 and given it substantial thought. However, I devoted more than 30,000 hours since 1979 to solve this problem. I cured myself from FMS, CFS, congestive heart failure, IBS, MCS, etc. So here we have FMS-CFS that have been attributed to multiple causes through the years from physical trauma to viruses or bacteria. In high resolution symptoms so instead of diagnosis level “peripheral neuropathy” one might instead describe all the different symptoms. Something amazing happens. The causes become visible. FMS/CFS are something that develops as opposed to “catching”, like the flu.Basically FMS/CFS are variations on “failure to heal”. As the body keeps trying to heal, from anything, often around 3 to 6 months the symptoms start changing. After a certain point some resources get too low for “X” to heal and “Y” and “Z” symptoms appear and are both deficiency symptoms. Basically a person gets slow motion refeeding syndrome. This gets a person stuck in a multi way deadlock. The basic deadlock is a partial methylation block teamed up with ATP block. The most basic level of the block is MeCbl with L-methylfolate on one end and AdoCbl with L-carnitine fumarate (90% of people, ALCAR 10%) at the other. Vit D, magnesium, zinc and some other items can deadlock these items as well. Each branch, methylation and ATP, has another half dozen or more items that affect various portions of these functions. Typically on the third day after methylation starts a person can feel very sick as they go into potassium deficiency and l-methylfolate deficiency (which happens by compartment).Then each time there is more cell formation. Then the response is limited by ATP production, AdoCbl and l-carnitine fumarate which as soon as it is started increases the need for potassium and methylfolate again in a few days. And to avoid adding 20 or 30 more items into things that stop healing one is taking all the basics before starting and also needs to avoid some things. Once one gets the basic cycle s going there are patterns of repeating symptoms as different things run out. It took me 6 years to run low enough on copper for symptoms to occur (low doses in basics) and 5 years to recognize the induced copper deficiency symptoms and a lot of damage happened. I have many of the symptoms patterns mapped. With FMS/CFS the first 150 symptoms are relatively quick and easy. The tough ones are latter appearing symptoms that look familiar but are in a different pattern. It is quite complicated.Added 10/21 - When one tries the nutrient that is the actual item deficiency preventing cell formation, the difference can be noticed quickly.MeCbl - sublingual or nasal spray, may be noticed in 5 minutes, 75% of those likely to respond by questionnaire respond noticeably within 1 hour, beneficial effects may disappear by day 3 when refeeding deficiency symptoms become prominent, especially methylfolate and potassium deficiencies.AdoCbl - sublingual, may be noticed in 5 minutes, 75% of those likely to respond by questionnaire respond noticeably within 1 hour, beneficial effects may disappear by day 3 when refeeding deficiency symptoms become prominent, especially methylfolate and potassium deficiencies.L-methylfolate - Deficiency symptoms start changing within several hours, reinvigorated folate deficiency symptoms (refeeding syndrome by compartment) appear along with potassium deficiency symptoms.L-carnitine fumarate - Oral capsule, may produce noticeable results in 30–60 minutes improving energy and affecting mood. Again, about day 3 symptoms change to increased refeeding syndrome symptoms of potassium and methylfolate deficiencies.Copper - Copper and other trace nutrients usually take longer to appear and affect fewer symptoms. When copper is deficient and taken, positive effects can be seen often in 2–4 hours and no doubt in 24 hours. In 3 days if a small dose of copper is taken, the positive effects start fading and the deficiency symptoms increase. Also serum copper decreases after small doses, possibly by compartment in way similar to increasing deficiency symptoms with small doses like l-methylfolate. I had to titrate to 25 mg daily to get steady improvement.Version 2.2 08/10/2016 A work in process, incomplete, limited testing, people come in many variations, use at your own risk.INDUCED DEFICIENCY SYMPTOMS FROM REFEEDING SYNDROME. This can follow 5 days of food deprivation, anorexia, or sort of a pinpoint starvation via vitamin or mineral or amino acid deficiencies. Whatever the “most needed” item is will often cause a strong response. The first usual notable symptoms occur on typically the third day of starting a previously insufficient nutrient. For instance it was noted in the 50s with injections of B12 with potassium deficiency (hypokalemia) as a side effect. It is dangerous and can be unpredictably fatal if not corrected and the cause is continued. When they say people are dying in Syria after they have been starved and given food, they are often sufferring REFEEDING SYNDROME. When previous symptoms returnGroup 1 – Hypokalemia onset. Often called “detox”. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (Cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.IBS – Steady constipation, Nausea, Vomiting, Paralyzed Ileum,Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weaknessAbnormal heart rhythms (dysrhythmias), increased pulse rate, increased blood pressureEmotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.Group 2a - Both hypokalemia and l-methylfolate deficiencyIBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipationGroup 2b – Either or both hypokalemia and l-methylfolate deficiencyHeadache, Increased malaise, FatigueGroup 3 - Induced and/or Paradoxical Folate deficiency or insufficiency, partial methylation block to methyltrap on 1 or more internal triage levels. Frequently called “NAC DETOX” or “GLUTATHIONE DETOX”. Can be caused by folic acid, folinic acid and for some people, like me and quite a few others, excess vegetable folates. Further excess B1, B2, B3 and/or inositol can increase methylfolate deficiency symptoms.These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.Old symptoms returning in a general sense, a person may have had onset of these hundreds of time if they are on the borderlineEdemaAngular Cheilitis, Canker sores,Skin rashes, increased acne, Increased itchy acne on scalp and face, Skin peeling around fingernails, Skin cracking and peeling at fingertips, painful cracks in the skin at the corner of fingernails at approximate right angles to nails, can take months to occur and it may be only non mood or neurological symptoms.IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipationHeadache, Increased malaise, FatigueIncreased hypersensitive responses, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptomsIBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract,Coated tongue, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Increase irritability, Heart palpitations,Longer term, very serious:Loss of reflexes, Fevers, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, bleeding easily.Group 4 - HyCbl onset, degraded MeCbl onset, MeCbl after photolytic breakdown onset.Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.Group 5 – Copper deficiency after methylation startup has been achieved which often starts refeeding syndrome. 50mg or more of zinc has been indicated as a possible cause. 200-400 mg of zinc has been linked to copper deficiency. Excess supplemental or environmental manganese is linked to copper deficiency. Any or all symptoms can occur at “low normal range” copper tests.Demyelination of nerves similar to Sub Acute Combined Degeneration except that methylation and ATP startup has occurred, and copper deficiency favors damage to the upper motor neurons with perceived muscle weakness. Brittle nails. Sleep disorders. Mood (especially depression perhaps) and personality changes. Connective tissue breakdown. Spider veins. Varicose veins. Shrinking gums. Gum disease not responsive to usual measures. Unstoppable tooth decay on exposed areas without enamel. Low testosteroneGroup 6 – Excess P-5-P, an active form of B6 that appears to drive hematocrit.High hematocrit. The blood thickens and doesn’t pump as easily. Deep vein thrombosis can result. Other suspected circulatory hazards. Sometimes linked to high testosterone when lowering P-5-P might reduce it.Group 7 – Excess B-vitamins affecting methylationWhen taking the active B12/folate deadlock quartet (AdoCbl, MeCbl, Metafolin, L-methylfolate) Excess B1 - Thiamin, Excess B2 – Riboflavin, Excess B3 – Niacin and/or Excess Inositol can all produce an excess need for potassium to deal with Groups 1, 2a and 2b symptoms and/or produce an excess need for l-methylfolate to reduce groups 2a, 2b and 3 symptoms. A person might not be able to correct by taking potassium or folate and may need to reduce B1 <= 15mg/day, B2<= 10.2mg/day, B3 <=50mg, and inositol below an unknown quantity.Group 8 – Boron insufficiency.Arthritis swelling and pain, can be reduced by BoronContribution to fatigue, neurological effectsHealth Benefits of Boron | Organic FactsAlthough all of the deficiency symptoms of boron are not fully understood, it is known that boron deficiency might result in the abnormal metabolism of calcium and magnesium. Some of the other symptoms include hyperthyroidism, sex hormone imbalance, osteoporosis, arthritis and neural malfunction.

What supplements have (or potentially have) benefits when taken in higher quantities?

I developed a questionnaire with several hundred symptoms, high detail symptoms, so that something like "peripheral neuropathy" might break into 20 or more symptoms, sometimes said the way medical folks might state it as well as common usage in many variatyions. The purpose is to describe in such a way that they say "That's me". The computer program takes care of scoring the symptoms. In my years in the business I found way too many people don't recognize it if described only one way. I learned how to take thorough detailed histories is another way to say it.Vitamins don't make things happen, generally. They allow things to happen. However, some vitamins have multiple "internal triage levels" where it takes different doses and assisting vitamins or other nutrents to activate each level. B12 and folate have very paradoxical looking symptoms. Many are what are often disparagingly referred to as "functional" deficiency symptoms as opposed to the "hard" deficiency symptoms. By the time these are defined the damage is already well under way and may not be reversible, after potentially decades of "meaningless" functional symptoms.Let's get back to the questionaire. Tell me, why are the symptoms of B12 deficiency worthy of being treated ( respond to the official B12 - CyCbl or HyCbl or both, only in Japan is it MeCbl) different in different countries? I combined all the symptoms from all the countries.Then I took symptoms histories of over 1000 people, each one having an already tested for effectiveness brand of Methylcobalamin. Of the 1000 people, of average age span expected to be healthy either traveling, at conventions or at resorts and outdoor recreation clubs of various kinds. About 500 put down significant numbers of symptoms of these B12 and Folate deficiency symptoms. 75% of those who had significant numbers of grouped symptoms responded within 1 hour to an effective sublingual MeCbl tablet. When AdoCbl, L-methylfolate and L-carnitine fumarate (or ALCAR for 10%) are added with appropriate timing, response in 60 minutes goes up to 95%.Then 20% of the ones who didn't remember any symptoms or only a couple of them had sizable 60 minute responses and suddenly remembered dozens of "non specific" "insignificant" "unimportant" symptoms when they started changing. They had all removed those symptoms from noticing as their doctor basically said ignore them.Not a single one of the 60% who had symptoms in the end however had the obvious symptoms that would have forced diagnosis, like pernicious anemia. B12 definitions minimize treatment and wait until it is way too late.The folks that had responses all had symptoms that were changed. For instance going from "permanently tired" to very energetic in an hour is a common reaction. It doesn't happen unless the person had deficiency type symptoms, i.e. "permanently tired" in the first place.The other 400 or so others had no 60 minute or longer response and had no symptoms on the list of responding symptoms. Methylcobalamin is non-linear dose proportionate as is Adenosylcoblamin and L-methylfolate. They each approach their respective limits.On the other hand B1, B2, B3 and folic acid at the very least, have inverted U shaped dose proportionality. That means they reach a peak of benefit and then fall off in effectiveness and in some cases going negative by over-driving or even blocking some pathways. As the above active forms of vitamins (AdoCbl, MeCbl, MTHR) are more active they are more sensitive to the vitamins that drive those pathways in various ways.The rest of b-vitamins and other I have no opinion as to the type of dose response relationship they have. The published works are almost always based on the less active vitamirs interactions if other vitamins are considered at all.Some of the vitamins in too large a dose can be dangerous to some people. I don't know of any vitamins that force beneficial reactions. For instance, widespread healing can be allowed to happen in the body if all conditions needed are met but one can't make it happen. I don't know of any high dose vitamins that don't top out at NORMAL GOOD. It's just that the required dose to hit "NORMAL GOOD" varies a lot from person to person.However, that doesn't mean that some vitamins don't seem to have a lot of effect when actually the person was very deficient. We notice percentage of increase. So going from 0.1% to 20% functioning is a 200x increase and is perceived as huge. Going from 20% to 100% is only 5x and is still a good boost but not huge.So much less is known about some supplements. For instance glutathione is all the rage in some circles. Because of my genes glutathione causes "catastrophic B12 deficiency" for me and others like me. And depending upon dose possibly others. If continued for long it can cause Sub Acute Combined Degeneration and general multi organ multi system failure. Messing around with some of these things can be dangerous, even some common practices, all because of gene differences including some very common ones.

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