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PDF Editor FAQ

Hypothetically, if a foreign government managed to occupy the southern US, how long would it be until gun owning American citizens expelled them?

Perhaps a month before the last of the invaders was killed, captured or escaped.Those that think a foreign invader could prevail due to weapon superiority fail to grasp the limitations on the use of those weapons and assets a resistance would have.The unorganized militia includes millions of military veterans as well as active-duty members of the National Guard and state guard units.IEDs, sniper fire, familiarity with the territory, support of the populace and other factors would also work against an invading army. Destruction of supply lines and disruption of communications would be much more effective, and preferable, to any pitched battles.Snipers capable of hitting a target as much as a mile away will hamper the effectiveness of commanders. Occupying soldiers would find it very difficult to venture out in less than platoon strength, sapping the occupier’s resources.As much military materiel as could possibly be squirreled away would be taken before the invading force could become an occupying force and what couldn’t be taken would be destroyed. This includes any airfields or runways long enough to accommodate even light bombers or cargo aircraft.The American South is fairly heavily armed and none of the states have gun registration. Since the invasion couldn’t happen overnight, civil authorities would have the opportunity to destroy records of purchase permits, carry permits and other things that might help an invader determine who has guns.Americans not only have guns, they have lots of them. Plenty to go around.Artillery, bombers and such are only useful against strategic targets; trying to use them against small, mobile groups is wasteful of materiel that could be difficult to replace. If they are used to create terror, the resistance will only increase in size and ferocity. Moreover, the more an occupier has to destroy, the less reason that occupier has to stay.Even modern technology, such as infrared sensing, ground-penetrating radar and such, isn’t an automatic guarantee of success. There’s no reason to believe that any other military would have had any greater success than the former Soviet Union of U.S. did in Afghanistan.I don’t recall any invading military force in history that would have confronted the challenges facing a foreign invader that tried to occupy the American South.

What is wrong with this cure for cancer? Develop a database of the cell cycle, identify the cancer-modified normal cell behavior, simulate the networks, identify cause for the cells to switch back to healthy patterns, design and test drugs.

It's not so much that your answer is wrong, as much as each step you mentioned is so vague and ill-defined that it contains virtually no useful content. Let's consider them in order:Step 1: "Develop a very accurate database of knowledge of the cell cycle and how cell behavior is caused by patterns of expression of genes, etc."This has essentially been the project of thousands of scientists around the world for decades. It's akin to saying "Step 1: Figure out how cell genetics works." Not an incorrect assessment, but WAY easier said than done. As for the number of control genes-- that says little about the vast emergent complexity of the effects of their alteration (which must be thoroughly understood to create effective cancer treatments.)Step 2: "For the type of cancer in question, identify the ways the cancer modifies and disrupts the normal cell behavior. (This should amount to changes in gene and protein networks)."This step suffers from the same basic flaw as the first question; it catastrophically underestimates the difficulty of understanding all the relevant ways cancer disrupts normal cell behavior. It's also something scientists have been working to understand for decades. It also amounts to more than just "changes in gene and protein networks" (which in and of themselves are incredibly complex)- it's a multi-scale problem involving cell-to-cell interaction, and other interactions at the "macro" level. People tend to vastly underestimate the complexity of biological systems in general, which is one of the reasons people have trouble understanding why cancer hasn't been cured yet. In summary, Step 2 basically amounts to saying nothing more than "Figure out how cancer works."Step 3-4: "Simulate the networks in question, and the disruptions (mutations etc.) due to cancer." and " Identify via computer simulation which interventions to the network will cause the cells to switch back to healthy, desired patterns of expression and behavior."Simulating the chaotic world of biology is an enormously computationally-expensive task. To get some sense of this complexity, see:http://www.quora.com/search?q=simulate+a+living+cellIt's not even clear from the standpoint of theoretical computer science whether we currently have the technology to simulate all of the relevant effects of cancer mutations. Even if it is possible, we're not anywhere close to having simulations that are that sophisticated. So once again, a HUGE conceptual advance would be required to complete such a task.5. "Design and test (in silico and vitro) drugs which will put the network back in a desirable state"This a another simplification of an incredibly complicated task. There is currently no conceivable way to do this step entirely in silico and in vitro. The complexity of the system requires that in vivo testing is necessary as well. Part of the difficulty is that not only do the effects of a given drug have to be tested on the cancer cells but on healthy cells as well, so that researchers can determine whether or not the drug has negative side-effects on healthy tissue. Killing cancer cells is easy; singling them out is hard.6. "Find ways to deliver the drugs (probably protein drugs?) efficiently."This is also way easier said than done, and finding ways to successfully deliver drugs has been extremely difficult and will continue to be so for the foreseeable future. This also requires huge conceptual advances. I recently read about a group of scientists (trying to find the article now) who were trying to build magnetically-guided nano-containers that could deliver otherwise dangerous substances directly to cancer sites. Delivery is no trivial task by any stretch of the imagination.These are only a few of the thousands of the barriers to curing cancer. I've barely scratched the surface. So it's not that the path you've outlined is wrong per se; it just glosses over mountains of relevant details.

I am curious to know that in a country, where Ambanis and Tatas are household names, are there businessmen that are doing great work but not many people know about them? Who are some of the successful but not well-known Indian businessmen?

Pralhad P Chhabria (former chairman of Finolex Group)Pralhad P. Chhabria began his career at age 12, as a cleaning boy in a small cloth shop in Karachi for a monthly wage of Rs. 10.Working his way through stints as a domestic servant, a collection agent, a trader in electrical accessories, and a supplier of defense contracts, he flourished with the unrelenting instinct of the entrepreneur. Finolex, established in Pune in 1958 by Pralhad Chhabria and his younger brother Kishan or K.P. Chhabria, is today the number one manufacturer of cables in India, and second only to Reliance in the manufacture of PVC resin.Witness to the misfortune and disruption of Partition, P.P. Chhabria himself suffered a series of tragedies. It was only his single-minded persistence and commitment to work and growth that gave him the strength to forge ahead.P.P. Chhabria’s formal education ended when he was only in class 2. In his book, this reserved and even rather reclusive gentleman describes how he learned all that he needed to know to be the leader of a large corporation. He shares his experience and subsequent learning in the areas of Sales, Finance, Quality, and people management, and tells what he did to build an enviable, almost formidable reputation for both Finolex and himself.With no management mantras to follow, he applied a hands-on approach to his powerful vision, absorbing the various lessons of each step. His unassuming style attracted a devoted team to whom, the company now belongs. He attributes his every success to this team, and to the forces of nature that guided him through difficult circumstances and helped him take decisions.This fascinating story depicts a unique Indian businessman with an international business outlook and a very traditional personal life, and his book is a must-read for every student of management in this country, every young aspirant setting out on the rocky road of entrepreneurship, and for every forward-thinking human being struggling with various facets of existence.He breathed his last on May 5, 2016.In 1981, they established Finolex Industries. The 1990s saw Finolex diversify into optic fibre cables and copper rods. Today, Finolex group has grown into a Rs 10,000 crores conglomerate.

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