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If you accidentally ingested rat poisson, please see a doctor! If you are just curious about what actually makes up rat poisson, please read on.Common active ingredients in rat poisson include:BrodificoumDiphacinoneWarfarinBromadioloneThese four ingredients have the some sparse information about lethal dose available. Note that rat poisson is made for rats, so the median lethal dose (LD50) is very detailed for different species of rats, but information on the effects on humans is limited to accidental administration of the poisson.BrodificoumThese cases are known ingestion of brodifacoum by humans [1]:The ingestion of thirty 50 g packages of brodifacoum over a two-day period by a 31-year-old psychotic woman produced generalized ecchymosis and abortion. The estimated ingested dose was 75 mg (Lipton & Klaas, 1984).A 17-year-old male adolescent ingested approximately 7.5 mg (0.12 mg/kg) of brodifacoum and was admitted to the hospital with flank pain and important haematuria, followed by epistaxis and gum bleeding. Therapy with vitamin K1 had to be maintained for over 50 days (Jones et al., 1984).The ingestion of 1 mg of brodifacoum in an adult produced bleeding that persisted for more than 2 months (Chong et al., 1986). No clearly defined toxic dose has been established in the human, and few clinical reports are available.DiphacinoneThese cases are known ingestion of diphacinone by humans [2]:On chronic toxicity:No permanent or life-threatening effects occurred in humans on recommended dose regimes of an initial 20 mg dose (ca. 0.29 mg/kg in a 70 kg human), followed by successive 2 to 4 mg daily doses (ca. 0.03 to 0.06 mg/kg/day in a 70 kg person) for several days to weeks.On acute toxicity:Use in humans as an anticoagulant drug has been apparently discontinued, possibly due to its structural similarity to another compound (phenindone). Phenindone was noted to pose risks of hepatitis with jaundice, damage to kidneys, severe skin irritation, and and massive tissue swelling. The use history of diphacinone indicates that it produced no adverse health effects except occasional nausea and some hemorrhagic effects that persisted for 6 to 10 days.WarfarinThese cases are known ingestion of warfarin by humans [3, 4]:On acute toxicity:Toxicity values for humans exposed to warfarin indicated an oral-woman TDlo of 15 mg/kg/21 weeks intermittent; 10,200 ug/kg oral-man TDlo; and 6,667 mg/kg oral-human LDlo. Average or large doses of warfarin in humans may cause hemorrhage. Warfarin is not known to be an eye irritant. It has produced hemorrhages in the retina, however, through its systemic toxicity. The compound is considered highly toxic by inhalation and ingestion and moderately toxic by dermal absorption. A dose of warfarin at 200 mg/m3 is considered highly toxic and immediately dangerous to life or health.It has been reported that 6.667 mg/kg is the lethal oral dose [Yakkyoku 1977] [Note: This is equivalent to a worker being exposed to about 300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.].BromadioloneThis is one of the known cases of ingestion of Bromadiolone by humans [5]:Ingestion of bromadiolone can lead to prolonged and life-threatening coagulopathy. Traditional treatment of bromadiolone intoxication relies on the coagulation profile. Currently, there is scanty information on bromadiolone elimination kinetics and half-life. A case of bromadiolone poisoning in a 40-year old female who, by history, ingested four 42.5-gram bags of rat poison (0.005% bromadiolone), equivalent to 8.5 mg bromadiolone (0.17 mg/kg body weight), four days prior to admission /was reported/. On admission, her prothrombin time was 92.0 seconds, international normalized ratio was 5.7, and activated partial thromboplastin time was 50.2 seconds with no bleeding on clinical examination. The first plasma bromadiolone level (5 days post-ingestion) was 92 ng/mL. Serial measurement of plasma bromadiolone levels confirmed the diagnosis and demonstrated that bromadiolone obeys the elimination kinetic of a two-compartment model with a rapid, fairly steep decline phase (half-life 3.5 days) followed by a slower termination phase (half-life 24 days). Plasma bromadiolone level of less than 10 ng/mL in /this/ patient was associated with a consistently normal coagulation profile without vitamin K1 therapy.[1] Brodifacoum (PIM 077)[2] EXTOXNET PIP - DIPHACINONE[3] Warfarin[4] NIOSH Publications and Products[5] National Library of Medicine HSDB Database

If you accidentally ingested rat poisson, please see a doctor! If you are just curious about what actually makes up rat poisson, please read on.Common active ingredients in rat poisson include:BrodificoumDiphacinoneWarfarinBromadioloneThese four ingredients have the some sparse information about lethal dose available. Note that rat poisson is made for rats, so the median lethal dose (LD50) is very detailed for different species of rats, but information on the effects on humans is limited to accidental administration of the poisson.BrodificoumThese cases are known ingestion of brodifacoum by humans [1]:The ingestion of thirty 50 g packages of brodifacoum over a two-day period by a 31-year-old psychotic woman produced generalized ecchymosis and abortion. The estimated ingested dose was 75 mg (Lipton & Klaas, 1984).A 17-year-old male adolescent ingested approximately 7.5 mg (0.12 mg/kg) of brodifacoum and was admitted to the hospital with flank pain and important haematuria, followed by epistaxis and gum bleeding. Therapy with vitamin K1 had to be maintained for over 50 days (Jones et al., 1984).The ingestion of 1 mg of brodifacoum in an adult produced bleeding that persisted for more than 2 months (Chong et al., 1986). No clearly defined toxic dose has been established in the human, and few clinical reports are available.DiphacinoneThese cases are known ingestion of diphacinone by humans [2]:On chronic toxicity:No permanent or life-threatening effects occurred in humans on recommended dose regimes of an initial 20 mg dose (ca. 0.29 mg/kg in a 70 kg human), followed by successive 2 to 4 mg daily doses (ca. 0.03 to 0.06 mg/kg/day in a 70 kg person) for several days to weeks.On acute toxicity:Use in humans as an anticoagulant drug has been apparently discontinued, possibly due to its structural similarity to another compound (phenindone). Phenindone was noted to pose risks of hepatitis with jaundice, damage to kidneys, severe skin irritation, and and massive tissue swelling. The use history of diphacinone indicates that it produced no adverse health effects except occasional nausea and some hemorrhagic effects that persisted for 6 to 10 days.WarfarinThese cases are known ingestion of warfarin by humans [3, 4]:On acute toxicity:Toxicity values for humans exposed to warfarin indicated an oral-woman TDlo of 15 mg/kg/21 weeks intermittent; 10,200 ug/kg oral-man TDlo; and 6,667 mg/kg oral-human LDlo. Average or large doses of warfarin in humans may cause hemorrhage. Warfarin is not known to be an eye irritant. It has produced hemorrhages in the retina, however, through its systemic toxicity. The compound is considered highly toxic by inhalation and ingestion and moderately toxic by dermal absorption. A dose of warfarin at 200 mg/m3 is considered highly toxic and immediately dangerous to life or health.It has been reported that 6.667 mg/kg is the lethal oral dose [Yakkyoku 1977] [Note: This is equivalent to a worker being exposed to about 300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.].BromadioloneThis is one of the known cases of ingestion of Bromadiolone by humans [5]:Ingestion of bromadiolone can lead to prolonged and life-threatening coagulopathy. Traditional treatment of bromadiolone intoxication relies on the coagulation profile. Currently, there is scanty information on bromadiolone elimination kinetics and half-life. A case of bromadiolone poisoning in a 40-year old female who, by history, ingested four 42.5-gram bags of rat poison (0.005% bromadiolone), equivalent to 8.5 mg bromadiolone (0.17 mg/kg body weight), four days prior to admission /was reported/. On admission, her prothrombin time was 92.0 seconds, international normalized ratio was 5.7, and activated partial thromboplastin time was 50.2 seconds with no bleeding on clinical examination. The first plasma bromadiolone level (5 days post-ingestion) was 92 ng/mL. Serial measurement of plasma bromadiolone levels confirmed the diagnosis and demonstrated that bromadiolone obeys the elimination kinetic of a two-compartment model with a rapid, fairly steep decline phase (half-life 3.5 days) followed by a slower termination phase (half-life 24 days). Plasma bromadiolone level of less than 10 ng/mL in /this/ patient was associated with a consistently normal coagulation profile without vitamin K1 therapy.[1] Brodifacoum (PIM 077)[2] EXTOXNET PIP - DIPHACINONE[3] Warfarin[4] NIOSH Publications and Products[5] National Library of Medicine HSDB Database