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Why do medical researchers still not know how allergies are being triggered?

I talked and corresponded with a number of researchers on related matters. What I can't do is give you a highly technical biochemical explanation that despite being very exacting and verified by research of biochemical processes can't deliver the basic understanding of how not to have at least some allergic responses and allergic asthma in some people. I used to have seasonal allergies and had allergic asthma reactions. I had these for most of my life until I started getting rid of them 12 years ago. It actually turned out to be much simpler, at least for me, than it looks when reading any of the explanations. I found that when I have severe enough MeCbl (methylcobalamin, methyl b12) deficiencies that at least on some levels puts my body into methyltrap thereby excluding L-methylfolate from the cells that allergic responses start building in days and asthma comes back in about 2 weeks, via experience.Knowing then how to not have hypersensitivity reactions, general inflammation, Multiple Chemical Sensitivity, no need in 12 years for antihistamines or asthma medications, makes the explanation obvious why medical researchers as a whole have no idea about it. For the last 67 years most B12 research was done concerning CyCbl and later HyCbl. "Folate" became folic acid and again got most of the research.MeCbl and L-methylfolate with AdoCbl and the correct for the person form of L-carnitine so there is no methylation - ATP mutual deadlock, and sufficient doses can allow the body not to have to respond allergically. Because CyCbl (Cyanocobalamin) and folic acid can cause partial methylation block and/or methyltrap giving increasingly severe folate deficiency symptoms, doing studies of them will not reproduce what the real human effective l-methylfolate, AdoCbl (adenosylcobalamin) and MeCbl with l-carnitine can do. These have only been available for 10-20 years. There are multiple genetic polymorphisms that affect these responses so that some of us HAVE TO USE the active forms only.There are hazards in turning on taking these nutrients and turning on widespread healing. A person can have refeeding syndrome triggered and need pretty sizable doses of potassium to prevent hospital ER visits and even death. Then there will be other deficiencies, especially l-methylfolate, caused over and over. Also, MeCbl can prevent Botox from being useful, for about a day with each suitably sized dose. It "cures" avian botulism. It can also block tetanus neurotoxin so it is difficult to diagnose because the usual symptoms are not there.This can be demonstrated very easily, and with the right screening questionnaire and interpretation, the people can be selected who will generally predictably demonstrate such responses.I'm not a doctor or other than amateur researcher. I'm a systems analyst, group health insurance consultant and software designer and writer for HMO and insurance plans. I was sick my whole life and dying. Nobody was going to solve my problems for me having been to over 100 doctors totally unable to solve the puzzle or even recognize the nature of the problems. So I had to do it myself.One thing I want to add. Twelve years ago I weighed 285 pounds and had 200+ symptoms with diagnoses of FMS, CFS, asthma, allergies, daily vomiting, acid regurgitation at night, congestive heart failure, IBS, neuropathies of every type, peculiar blood CBC results, as well as damage form a car wreck and Sub Acute Combined degeneration. Since then using the active MeCbl, AdoCbl, Metafolin and l-carnitine fumarate (which I and some people specifically need as a vitamin) I have lost 85 pounds of water, 40 pounds of fat and restored 50 pounds of previously atrophied muscles. My thigh muscle was only as thick as my thumb at that time. Now I have the symptoms of damage from the car wreck, reduced neuropathy and Sub Acute Combined Degeneration symptoms. I walk 2.5 miles in 30 minutes. I no longer take most of the medications I took then and no medications replacing them. No more diuretic. No more asthma or allergy medications, no more Compazine suppositoties, no more Dilantin. No more 2400mg of Ibuprofen daily. I can do everything I couldn't do for 20 years. I'm in the best health of my life, at 67.

How much money do sperm donors make in India?

This answer may contain sensitive images. Click on an image to unblur it.SpermSelling your seed can net you up to a $1000 a month, but it’s not as easy or as fun as the media (or movies) makes it sound, and very few men actually qualify. You need to be in excellent health, have a clean medical background, be within a certain age, height and weight range, have a post secondary education, and be attractive (who determines that, we are not sure). You can’t use tobacco or another drugs (in any form), and can’t be a heavy drinker. You also need to be able to “deliver” an amount of sperm that is about twice that of what a typical guy produces. If you meet the rigorous requirements, theoretically, you could donate once every 24 hours but most sperm banks prefer variety and may not want large amounts of your sperm. We know you are special, but the world doesn’t need 200 of you. Compensation for your DNA can range from $35 to $100 depending on the size of the sperm bank, how much sperm you can produce in a single session, and how often you donate. Anonymous donors typically get paid less as well. An individual sperm, on average is worth about 0.00000033 cents each, but don’t worry, men produce anywhere from 40-600 million sperm per session.Being a sperm donor takes two basic male desires — orgasms and money — and, in a seemingly "too good to be true" moment, combines them. That said, sperm banks hold to exceptionally high standards: The extensive, multilayered screening process eliminates about 95% of us.Prepare to expose your family tree to a thorough, honest dissection, going back two generations. You'll be asked about tattoos, drug use, experimental sex, your grandma's TB, your uncle's alcoholism, and your mother's schizoid episodes.If invited in, you'll be given a sterile cup and offered "aides" in the form of movies or magazines, or both; just don't count on a hand job from the hottie at the front desk. You'll be instructed not to use a lubricant, as it can contaminate the "specimen" (or load, or wad, whichever you care to call it). Your boys will then be tested for everything from the obvious (sperm count) to the unexpected (forward momentum), and that's just for starters.If accepted as a donor, you'll earn between $50 to $200 per specimen. You'll be expected to rub one out into their cups two to three times per week and make a commitment to the program that lasts six months or longer depending on the policies of the clinic. Because they need a consistently potent specimen, you'll have to abstain from having an orgasm anywhere but at the clinic; and yes, they'll know if you're cheating on them.Sperm banks can be found in almost every major city, but because of discretion, they aren't always easy to locate. You can try a Yellow Pages search for "sperm banks" in your area, or there are websites such as SpermBanker.com that operate as information clearing houses.Steps1. Determine if you are a viable candidate to donate sperm by meeting the basic requirements.You must be a healthy male between the ages of 20-40 (age range varies among facilities).You must be attending college or have graduated.You and your sexual partner must have no history of sexually transmitted diseases.You are required to make a commitment to stay in the area of the sperm donation clinic for 1 to 2 years and make up to 2 donations per week.Conditions that automatically disqualify candidates from donating sperm include hemophilia, HIV-positive status, intravenous needle use or a predisposition to certain genetic medical conditions.Candidates will also be disqualified if they were adopted, have had sex with another male, have engaged in intravenous needle use, or have smoked marijuana or used cocaine (past or present use).After meeting the initial requirements, continue to the screening process.2. Schedule a screening appointment with your chosen clinic.3. Attend your appointment. Be prepared to participate in any of the following events.Complete a thorough medical history questionnaire. Generational family history will be explored, as will your current and past health issues, if any.Provide a semen sample. The clinic will test the sperm for several different factors, including count, motility and viability. You may have to provide more than one sample.Submit to blood and urine tests. The clinic will evaluate for infectious diseases, genetic conditions, and perform blood typing.Receive a comprehensive physical examination.4. Get your application approved.Once you have been accepted into the clinic's donor program, you will be educated on the clinic's sperm collection process and the donation schedule. You will be compensated for each successful sperm donation. The sperm collection process, compensation fees and scheduling vary by clinic.Who cannot be donors?There are a number of reasons why a man cannot be accepted as a sperm donor. This is to minimize the risks of transmitting infection to those women inseminated with the donated sperm and to minimize the risk of transmitted common genetic diseases or malformations to any children born. Reasons for being unable to accept a man as a sperm donor include:AgeBecause there is evidence to suggest that genetic abnormalities are more common with older fathers, most men who donate are under 40 years of age.AdoptionPeople who are adopted can donate only if there is availability of a family medical history. It is necessary to examine their family history for evidence of serious inherited disorders that could be passed on to any children born following DI.PromiscuityAnyone who is sexually promiscuous is of increased risk of acquiring a sexually transmitted infection. Although each accepted donor is screened at the beginning and the end of the donation process, few clinics would risk taking on as a donor someone who may subsequently acquire an infection.DrugsCertain medicines as well as recreational drugs can affect the production of sperm or in some cases damage sperm. Moreover, the use of some recreational drugs can lead to sexual promiscuity and the risks that this carries.Heritable conditionsBecause some birth defects (e.g. spina bifida, cleft palate, hare lip) and serious diseases (e.g. diabetes, epilepsy, schizophrenia, asthma and hemophilia) are genetically linked, it is not possible to accept as a donor any individual where there is a family history of these conditions.TimeBecoming a sperm donor involves a regular commitment over several months, as well as being able to keep in touch with the center for about one year; a clinic would not normally be able to accept as a donor anyone who cannot make this commitment.Previous donationsBecause the number of children that can be born following the use of a donors sperm is regulated by law, a center would not accept as a donor an individual who has previously donated at another center.TipsThe screening process can take up to 6 weeks to complete.In some clinics, initial sperm donations are frozen and quarantined for an extended period. These donations are then retested for diseases. Once cleared, the donor will begin receiving compensation.Check with your clinic for sperm donation procedures. Some clinics require donations be made on-site, while others allow off-site collection. Off-site collections must be transported at body temperature and be received by the clinic within 1 hour of collection.WarningsNo ejaculations are permitted for up to 5 days before scheduled sperm donations.No lubricants, saliva, water, or condoms are allowed during the sperm donation process. These items can kill sperm.Donors must sign contracts denouncing any parental responsibilities or contact with offspring that may result from their donation.And mean while in China..Thank you……

What mitigation protocols should U.S. schools put in place to reopen this fall?

Going to a brick-and-mortar school should be optional. Why? Because I know kids that have asthma and respiratory conditions that could put their life at risk if they catch COVID. Some kids’ parents are afraid that they will lose a family member like themselves or their parents, especially, if they are at risk. There is mixed information about if kids can spread COVID to older people like their parents or grandparents, and to give the benefit of the doubt, it should be up to the parent to send their kids to school.If you can’t social distance, wear a mask. In the school hallways, there will be no opportunity to socially distance, unless a stupid policy is enforced, so I think that wearing a mask in the passing period is warranted. If possible, the desks should be 6 feet apart where students should safely take off their masks. The teacher should wear a mask at all times unless they are in front of the class teaching. Teachers are the ones most at risk and their health should be a priority. Perhaps, the older teachers can have a substitute or a younger teacher in training in the place of the teacher.Lunch should be the only time kids can be ‘free’. I don’t like the idea of having so many policies, especially after going to a high school that treated everyone like prisoners. I think lunch should be a time where can kids should socialize and be encourage to eat outside. Taking away a kid’s time to socialize with their friends is asking for problems and uncalled for.Encourage avoid using indoor halls. Outdoor halls will definitely help to have less ‘traffic’ between class periods.COVID Screening. My state allowed for summer practice to continue and every day, we had to get our temperature taken and fill out a yes/no questionnaire for providing safety for everyone. No one tested positive from my district which shows how effective and precautions this can be in the long run.Free COVID tests provided by the schools. At the beginning of every school year, my school district provides school supplies, vaccines, physicals, and more stuff to have a good start to the year, especially for low-income students. They should have free COVID tests as well, or instead of the supplies and allow families that test negative or families that no longer show COVID symptoms for 3–7 days.I understand why people are afraid of schools opening up and the danger it can cause to some families, but most students and teachers agree that online learning is so much inferior to learning in the classroom. I don’t think schools should open to full capacity, just like restaurants and stores don’t allow to open full capacity, however, school to many parents is not only the place their kids learn but a place that can act as a daycare and alleviate some stress to the parents. Taking precautions and giving parents the choice to send their kids to schools is the only way to allow for schools to reopen safely that could satisfy most people on both sides of reopening schools.

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