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PDF Editor FAQ

What's the one vegetable the doctor wants you to throw out immediately?

No, I would not listen to any doctor when it comes to food and nutrition.The following could be related to your query - the doctor might advice so when he /she found that vegetable1. the one that caused food allergy in you2. is known to cause drug and food /nutruent interactions with one of your medications.

If you were accidentally placed in a psych floor in a hospital, what would you say to convince the medical staff that you didn't belong there?

I'd say/do four things.I'd ask for a lawyer and not speak to anyone about my condition without that lawyer present, or his advice.I'd not sign anything or fill out any forms without my lawyer's approval.I'd warn them that my medical history includes multiple allergies to medications that includes antibiotics, sulfa drugs, some psych meds, muscle relaxants, and a very long list of common foods. (It's all mostly true for me.) Just try to give me meds that might kill me, it will please my lawyer very much.I'd let them know that not only does my insurance not cover my stay, but that my last stay in a hospital resulted in my winning a lawsuit for the nosocomial infection against that hospital. It was a particularly large award in light of my allergies to Sulfa drugs and antibiotics. So I'm happy to be there, even against my will, and still have that lawyer on speed dial!Just saying the word “nosocomial” can completely freak out hospital healthcare workers, particularly doctors and nurses. The word means that something in the hospital caused your infection, and huge awards are typically associated with these type lawsuits. It is a word they avoid saying in front of patients and their families at all costs, and will not be pleased that you know what it means. Malpractice insurance gets higher each time such suits are won, and even when they are only begun. If it becomes regular for hospitals/professional workers, they will find no one will cover them. This answer may not work for everyone else, but it's what I would do if I wanted to get out, as the question asks.

How does the new peanut allergy drug work?

While some allergies that affect the pediatric population resolve over time, peanut allergy tends to persist.Food allergens as triggers in different age groups (n=665, children and adolescents aged 0–17 years, adults from 18 years). Cases from the anaphylaxis register (1 January 2006 to 31 March 2013) [1]Accidental ingestion of the allergen (peanuts) is one of the most common causes of fatal/near-fatal anaphylactic reactions. Most patients with peanut allergy face the fear of anaphylactic reactions throughout their life. The current available treatment is strict avoidance of peanuts, and self-injectable Epinephrine, in the case of accidental exposure. I.e. this is huge unmet need from the perspective of the biotech industry [2].Aimmune’s AR101 for Peanut Allergy is based on oral immunotherapy (OIT) . OIT is a not a new concept, and has been studied for decades.What is OIT?In patients with peanut allergy, the allergen binds to Immunoglobulin E (among others), releasing pre-formed Histamine and other inflammatory molecules that generate the inflammatory immune response. This is augmented by a series of different reactions that lead to the production of additional inflammatory mediators ( cytokines interleukin-4 (IL-4), IL-5 etc).OIT, is a process by which the food allergen is administered slowly, in small but steadily increasing doses, to effectively reduce the sensitivity to food antigens (Ag) in patients. There is decades of work demonstrating safety of OIT, given that it is properly administered in a controlled setting. However, it is not yet clear the extent to which patients develop desensitization(DS) as opposed to sustained unresponsiveness (SU). DS, defined as a lack of clinical reactivity to Ag, and requires regular exposure to antigens for maintenance. DS is distinct from SU. In SU, patients exhibit a long-term or permanent loss of reactivity to Ag, which is independent of continued Ag exposure.In a typical OIT study, participants ingest small but gradually increasing doses of food Ag over a period of several months. The goal is to progressively retrain the immune response to establish DS and maybe, SU to the Ag.Example of an OIT study [3]So, what’s new?One must determine the most effective dosage and time frame for treatment. Further, we must learn whether or not OIT can desensitize large numbers of patients, and finally, if it can lead to tolerance. The clinical value of AR101 will be to allow the initiation of peanut immunotherapy with tiny initial quantities of peanut proteins that are required to safely launch oral desensitization.Footnotes[1] Guidelines on the management of IgE-mediated food allergies: S2k-Guidelines of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Medical Association of Allergologists (AeDA), the German Professional Association of Pediatricians (BVKJ), the German Allergy and Asthma Association (DAAB), German Dermatological Society (DDG), the German Society for Nutrition (DGE), the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS), the German Society for Oto-Rhino-Laryngology, Head and Neck Surgery, the German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Society for Pneumology (DGP), the German Society for Pediatric Gastroenterology and Nutrition (GPGE), German Contact Allergy Group (DKG), the Austrian Society for Allergology and Immunology (Æ-GAI), German Professional Association of Nutritional Sciences (VDOE) and the Association of the Scientific Medical Societies Germany (AWMF)[2] Peanut allergy market set for remarkable growth to 2027[3] ScienceDirect

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